TOPIC IV "Biomonitoring"

Biomonitoring is one of the monitoring strategies which are applied in the investigation and prevention of health effects caused by exposure to environmental pollutants. Biomonitoring includes the measurement of pollutants or their metabolites in biological matrices of an exposed organism. The results allow the assessment of the internal, individual dose of the hazardous substances and the detection of early biochemical effects as well.
Goal and task of the topic “Biomonitoring” is the development and application of liquid chromatographic based analytical methods (HPLC, LC-MS) which enable the determination of biomarkers of exposure and biomarkers of effect in biological samples.
The methods are applicable for the analysis of a broad range of biological matrices including human or animal urine, mouse plasma, cell extracts and cell medium. Due to their high performance they are essential components of projects studying different exposure scenarios and their effects on the exposed organisms.

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