TOPIC V "Comprehensive Chromatographic Separation"


The Research Topic “Comprehensive Chromatographic Separation” is performing research at the interface of the two main research areas of the JMSC namely “Enabling Analytical Technologies” and “Aerosols and Health”. The scientific goals are the development and translation of new and state-of-the-art analytical instrumentation and methods for their application in aerosol and health and other areas of environmental health. Key techniques are comprehensive two-dimensional gas chromatography (GC×GC) in combination with highly selective spectroscopic and mass spectrometric detection systems. Besides these, also thermal sample introduction techniques like direct insertion probe (DIP) and different thermal analysis (TA) approaches in combination with soft ionization techniques are established and utilized to expand the applied gas-phase ionization interfaces towards less- and non-volatile matrices. A major field of interest is also comprehensive and state-of-the-art data processing and data analysis of the generated multidimensional data.

Topic V is engaged in a wide range of projects with a focus on the priorities of the Helmholtz Zentrum München and the JMSC. Internal and third party funded projects in the last years focused on diabetes research, allergy research, and aerosols and health. These interdisciplinary studies always aimed to bridge the gap between chemical analysis and biological response. In this context, tight interaction with other institutes on the HMGU Campus and the other JMSC topics are aspired.

More technologically/methodically orientated projects are based on close cooperation with industrial or medium-sized external partners and are financed either by public support programs for mid-cap companies or by direct industrial funding. These projects have a clear focus on the application of our state-of-the-art or novel analytical techniques towards highly complex matrices.

A third area of interest is the further development of enabling technologies and its early adaption. In this context, the cooperation with the manufacturers of analytical systems makes a decisive contribution to maintaining the analytical-technical level and the availability of state-of-the-art analytical platforms at the JMSC. Beside hardware development, we also address data handling, processing and analysis to make the derived highly complex datasets accessible for interdisciplinary research.

Group contributions to Journals covers and Special Issues in the field of comprehensive chemical analysis and (from left to right: Analytical Chemistry 2009, Volume 81, Issue 11; Analytical Chemistry May 15, 2011 Volume 83, Issue 10; Analytical and Bioanalytical Chemistry, September 2013, Volume 405, Issue 22; Energy & Fuels, 2020, Volume 34).