HICE combines national and international expertise in analytical chemistry, aerosol science and chemical toxicology within a common, new concept. This concept is driven by two scientific hypotheses.

1) Reactive organic compounds in ambient aerosols, present either in the gas phase or the particle phase or in both phases are particularly relevant for the induction of the observed adverse health effects.

2) Synergistic effects of reactive organic compounds in the gas phase and the particulate phase play an important role in causing these effects.

In-vitro human lung model or animals are exposed in a defined character to fresh anthropogenic combustion aerosols. The biological repose is comprehensively characterised. Joint bioinformatical data analysis is aiming on the detection of biomarkers.