Complex Systems

Lung Research

Emphysema versus Airways disease

Chronic obstructive pulmonary disease (COPD) is characterised by the destruction of alveoli in the lung (Emphysema) and the inflammation and thickening of airway walls (Airways disease). Patients may exhibit both of these symptoms or one alone.

The aim of the project is to analyse confounding factors leading to each of the mentioned symptoms and to unravel causal factors fostering the progression of the disease.

Partner:

Lung microbiome in COPD

Chronic obstructive pulmonary disease (COPD) is characterized by the destruction of alveoli in the lung (Emphysema) and the inflammation and thickening of airway walls (Airways disease). Patients may exhibit both of these symptoms or one alone.

The aim of the project is to analyze whether physiological changes in lungs of patients suffering of different subtypes of COPD are associated to changes in composition of harbored microbiomes and to which extent that depends on the subtype under consideration.

Partners: 

Temporal development of lung microbiome in neonatal mice

Early-life development of the lung microbiome from the early neonatal period to adulthood in mice and the impact of external factors during these stages is under investigation. Are dynamic changes in early lung microbiome development resulting in a stabilization during adolescence or adulthood? Is there a core microbiome present during all developmental steps in life of mice?

Partners:

  • Prof. Dr. M. Schloter
  • M. Kostric

COMI

Environmental and mucosal microbiota and their role in childhood asthma

High microbial diversity in the environment has been associated with lower asthma risk, particularly in children exposed to farming. To find out, whether the higher diversity in the environment results in an altered microbiome of the mucosal surfaces of the airways, samples from mattress dust and nasal samples of school age children were analyzed and bacterial diversity and microbial community composition were related to farm exposure and asthma status.

Partners: