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New review in Science Magazine

The potential of Translational Genomics

In the latest Science special issue “Genotype to Phenotype”, Prof. Eleftheria Zeggini, Director of the Institute for Translational Genomics at Helmholtz Zentrum München, reviews the translational potential of genomics for common complex diseases. This will ultimately empower novel therapeutic approaches, personalized medicine and improved disease prevention.

Image: Improvements to human health that can be achieved through translational genomics. ©Helmholtz Zentrum München / Eleftheria Zeggini.

From an early disease prognosis using biomarkers to potential drug repurposing for treatment, Zeggini together with Anna L. Gloyn1,2,3, Anne C. Barton4,5 and Louise V. Wain6,7 discuss the potential of translational genomics. 

Fueled by technological advances in high-throughput genomics assays and the development of efficient computational tools for the analysis of big data, translational genomics is now poised to deliver in the field of common complex diseases. Zeggini and her colleagues discuss the value of translational genomics by highlighting recent innovations and listing the next set of challenges to be tackled (e.g. large cohorts across diverse ancestries with linkage to electronic health records) in order to take the next steps on the path from lab to clinic.

Original publication:
Eleftheria Zeggini, Anna L. Gloyn, Anne C. Barton, Louise V. Wain, 2019: Translational genomics and precision medicine: Moving from the lab to the clinic. Science, DOI: 10.1126/science.aax4588

1Oxford Centre for Diabetes Endocrinology & Metabolism, Oxford University, Oxford, UK
2Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
3Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK
4Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
5NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK
6Department of Health Sciences, University of Leicester, Leicester, UK
7National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK