Publications

2018

Essig, K.; Kronbeck, N.; Guimarares, JC.; Lohs, C.; Schlundt, A.; Hoffmann, A.; Behrens, G.; Brenner, S.; Kowalska, J.; Lopez-Rodriguez, C.; Jemielity, J.; Holtmann, H.; Reiche, K.; Hackermüller, J.; Sattler, M.; Zavolan, M.; Heissmeyer, V. Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat. Commun. Sept 2018, 9(1):3810. doi: 10.1038/s41467-018-06184-3

Baumjohann, D.; Heissmeyer, V. Posttranscriptional Gene Regulation of T Follicular Helper Cells by RNA-Binding Proteins and microRNAs. Front Immunol. Jul 2018, 31;9:1794. doi: 10.3389/fimmu.2018.01794.

Behrens G., Winzen R., Rehage N., Dörrie A., Barsch M., Hoffmann A., Hackermüller J., Tiedje C., Heissmeyer V., Holtmann H. A translation silencing function of MCPIP1/Regnase-1 specified by the target site context. Nucleic Acids Res. Mai 2018, 4;46(8):4256-4270. doi: 10.1093/nar/gky106

Hoefig, K.P.; Heissmeyer, V. Posttranscriptional regulation of T helper cell fate decisions. J Cell Biol Apr 2018, jcb.201708075; DOI: 10.1083/jcb.201708075

Rehage, N.; Davydova, E.; Conrad, E.; Behrens, G.; Maiser, A.; Stehklein, J.E.; Brenner, S.; Klein, J.; Jeridi, A.; Hoffmann, A.; Lee, E.; Dianzani, U.; Willemsen, R.; Feederle, R.; Reiche, K.; Hackermüller, J.; Leonhardt, H.; Sharma, S.; Niessing, D.; Heissmeyer, V. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat. Commun. 2018, 19;9(1):299.

 

 

 

 

2017

Essig, K.; Hu, D.; Guimaraes, J.C.; Alterauge, D.; Edelmann, S.; Raj, T.; Kranich, J.; Behrens, G.; Heiseke, A.; Floess, S.; Klein, J.; Maiser, A.; Marschall, S.; Hrabe de Angelis, M.; Leonhardt, H.; Calkhoven, C.F.; Noessner, El; Brocker, T.; Huehn, J.; Krug, A.B.; Zavolan, M.; Baumhohann, D.; Heissmeyer, V. Roquin Suppresses the PI3K-mTor Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity, 2017, 47: 1067.

 

 

2016

Tagawa, T.; Albanese, M.; Bouvet, M.; Moosmann, A.; Mautner, J.; Heissmeyer, V.; Zielinski C.; Lutter, D.; Hoser, J.; Hastreiter, M.; Hayes, M.; Sugden, B.; Hammerschmidt, W. Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. J Exp Med. 2016, 213 (10): 2065

Elhai, M.; Avouac, J.; Hoffmann-Vold, A.M.; Ruzehaji, N.; Amiar, O.; Ruiz, B.; Brahiti, H.; Ponsoye, M.; Frechet, M.; Burgevin, A.; Pezet, S.; Sadoine, J.; Guilbert, T.; Nicco, C.; Akiba, H.; Heissmeyer, V.; Subramaniam, A.; Resnick, R.; Molber, O.; Kahan, A.; Chiocchia, G.; Allanore, Y. OX40L blockade protects against inflammation-driven fibrosis. Proc Natl Acad Sci U S A. 2016, 113 (27): 3901.

Meininger, I.; Griesbach, R.A.; Hu, D.; Gehring, T.; Seeholzer, T.; Bertossi, A.; Kranich, J.; Oeckinghaus, A.; Eitelhuber, A.C.; Greczmiel, U.; Gewies, A.; Schmidt-Supprian, M.; Ruland, J.; Brocker, T.; Heissmeyer, V.; Heyd, F.; Krappmann, D.
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nat Commun. 2016, 12 (7): 11292.

Janowski, R.; Heinz, G.A.; Schlundt, A.; Wommelsdorf, N.; Brenner, S.; Gruber, A.R.; Blank, M.; Buch, T.; Buhmann, R.; Zavolan, M.; Niessing, D.; Heissmeyer, V.; Sattler, M.
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Nat Commun. 2016, 24 (7): 11032.

Halle, S.; Keyser, K.A.; Stahl, F.R.; Busche, A.; Marquardt, A.; Zheng, X.; Galla, M.; Heissmeyer, V.; Heller, K.; Boelter, J.; Wagner, K.; Bischoff, Y.; Martens, R.; Braun, A.; Werth, K.; Uvarovskii, A.; Kempf, H.; Meyer-Hermann, M.; Arens, R.; Kremer, M.; Sutter, G.; Messerle, M.; Förster, R.
In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.
Immunity. 2016, 44(2): 233-45.

Jeltsch, K.M.; Heissmeyer, V.
Regulation of T cell signaling and autoimmunity by RNA-binding proteins.
Curr Opin Immunol. 2016, 39:127-35.

Schlundt, A.; Niessing, D.; Heissmeyer, V.; Sattler, M.
RNA recognition by Roquin in posttranscriptional gene regulation.
Wiley Interdiscip Rev RNA. 2016, 7 (4): 455.

2015

Warth, S.C.; Hoefig, K.P.; Hiekel, A.; Schallenberg, S.; Jovanovic, K.; Klein, L.; Kretschmer, K.; Ansel, K.M.; Heissmeyer, V.
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.
EMBO J. 2015, 34(9):1195-213.

Srivastava, M.; Duan, G.; Kershaw, N.J.; Athanasopoulos, V.; Yeo, J.H.; Ose, T.; Hu, D.; Brown, S.H.; Jergic, S.; Patel, H.R.; Pratama, A.; Richards, S.; Verma, A.; Jones, E.Y.; Heissmeyer, V.; Preiss, T.; Dixon, N.E.; Chong, M.M., Babon, J.J.; Vinuesa, C.G.
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Nat Commun. 2015, 20(6): 6253.

Martinez, G.J.; Pereira, R.M.; Äijö, T.; Kim, E.Y.; Marangoni, F.; Pipkin, M.E.; Togher, S.; Heissmeyer, V.; Zhang, Y.C.; Crotty, S.; Lamperti, E.D.; Ansel, K.M.; Mempel, T.R.; Lähdesmäki, H.; Hogan, P.G.; Rao, A.
The transcription factor NFAT promotes exhaustion of activated CD8? T cells.
Immunity. 2015, 42(2): 265-78.

2014

Gewies, A.; Gorka, O.; Bermann, H., Pechloff, K.; Petermann, F.; Jeltsch, K.M.; Rudelius, M.; Kriegsmann, M.; Weichert, W.; Horsch, M.; Beckers, J.; Wurst, W.; Heikenwalder, M.; Korn, T.; Heissmeyer, V.; Ruland, J.
Uncoupling malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Cell Rep. 2014, 9(4): 1292-1305.

Jeltsch, K.M.*; Hu, D.*; Brenner, S.*; Zöller, J.; Heinz, G.A.; Nagel, D.; Vogel, K.U.; Rehage, N.; Warth, S.C.; Edelmann, S.L.; Gloury, R.; Martin, N.; Lohs, C.; Lech, M.; Stehklein, J.E.; Geerlof, A.; Kremmer, E.; Weber, A.; Anders, H.J.; Schmitz, I.; Schmidt-Supprian, M.; Fu, M.; Holtmann, H.; Krappmann, D.; Ruland, J.; Kallies, A.; Heikenwalder, M.; Heissmeyer, V.
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Nat Immunol. 2014, 15(11): 1079-1089.

Schlundt, A.*; Heinz, G.A.*; Janowski, R.; Geerlof, A.; Stehle, R.; Heissmeyer, V.; Niessing, D.; Sattler, M.
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Nat Struct Mol Biol. 2014, 21(8): 671-678.

Hoefig, K.P.; Heissmeyer, V.
Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.
Wiley Interdiscip Rev RNA. 2014, 5(4): 577-589.

Edelmann, S.L.; Heissmeyer, V.
Tfh cell differentiation: missing Stat3 uncovers interferons‘ interference.
Immunity. 2014 40(3): 307-309.

2013

Warth, S.C.; Heissmeyer, V.
Adenoviral transduction of naive CD4 T cells to study Treg differention.
J. Vis. Exp. 78 (2013)

Canis, M.; Lechner, A.; Mack, B.; Zengel, P.; Laubender R.P.; Koehler, U.; Heissmeyer V.; Gires, O.
CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.
Cancer Biomark. 12, 97-105 (2012)

Bronevetsky, Y.* ; Villarino, A.V.* ; Eisley, C.J.* ; Barbeau, R.* ; Barczak, A.J.* ; Heinz, G.A. ; Kremmer, E. ; Heissmeyer, V. ; McManus, M.T.* ; Erle, D.J.* ; Rao, A.* ; Ansel, K.M.*
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
J. Exp. Med. 210, 417-432 (2013)

Burger, K. ; Mühl, B. ; Rohrmoser, M. ; Coordes, B.* ; Heidemann, M. ; Kellner, M. ; Gruber-Eber, A. ; Heissmeyer, V. ; Strässer, K.* ; Eick, D.
Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA.
J. Biol. Chem. 288, 21173-21183 (2013)

Canis, M.* ; Lechner, A.* ; Mack, B.* ; Zengel, P.* ; Laubender, R.P.* ; Koehler, U.* ; Heissmeyer, V. ; Gires, O.*
CD133 induces tumour-initiating properties in HEK293 cells.
Tumor Biol. 34, 437-443 (2013)

Heissmeyer, V. ; Vogel, K.U.
Molecular control of Tfh-cell differentiation by Roquin family proteins.
Immunol. Rev. 253, 273-289 (2013)

Höfig, K.P. ; Rath, N. ; Heinz, G.A. ; Wolf, C. ; Dameris, J. ; Schepers, A. ; Kremmer, E. ; Ansel, K.M.* ; Heissmeyer, V.
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Nat. Struct. Mol. Biol. 20, 73-81 (2013)

Pesic, M.* ; Bartholomäus, I.* ; Kyratsous, N.I.* ; Heissmeyer, V. ; Wekerle, H.* ; Kawakami, N.*
2-photon imaging of phagocyte-mediated T cell activation in the CNS.
J. Clin. Invest. 123, 1192-1201 (2013)

Vogel, K.U. ; Edelmann, S.L. ; Jeltsch, K.M. ; Bertossi, A.* ; Heger, K.* ; Heinz, G.A. ; Zöller, J. ; Warth, S.C. ; Hoefig, K.P. ; Lohs, C. ; Neff, F. ; Kremmer, E. ; Schick, J. ; Repsilber, D.* ; Geerlof, A. ; Blum, H.* ; Wurst, W. ; Heikenwälder, M. ; Schmidt-Supprian, M.* ; Heissmeyer, V.
Roquin Paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Immunity 38, 655-668 (2013)

2012

Canis, M.* ; Lechner, A.* ; Mack, B.* ; Zengel, P.* ; Laubender, R.P.* ; Koehler, U.* ; Heissmeyer, V. ; Gires, O.
CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.
Cancer Biomark. 12, 97-105 (2012)

Frohn, A.* ; Eberl, H.C.* ; Stöhr, J.* ; Glasmacher, E. ; Rüdel, S.* ; Heissmeyer, V. ; Mann, M.* ; Meister, G.*
Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells.
Mol. Cell. Proteomics 11, 1442-1456 (2012)

Thomas, M.F.* ; Abdul-Wajid, S.* ; Panduro, M.* ; Babiarz, J.E.* ; Rajaram, M.* ; Woodruff, P.* ; Lanier, L.L.* ; Heissmeyer, V. ; Ansel, K.M.*
Eri1 regulates microRNA homeostasis and mouse lymphocyte development and anti-viral function.
Blood 120, 130-142 (2012)

2011

  • Thomas M.F., Abdul-Wajid S., Panduro M., Babiarz, JE., Rajaram M., Woodruff P., Lanier LL., Heissmeyer V., Ansel KM. (2011) Blood doi:10.1182/blood-2011-11-394072. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and anti-viral function.

  • Eitelhuber, A. C., Warth, S., Schimmack, G., Düwel, M., Hadian, K., Demski, K., Beisker, W., Shinohara, H., Kurosaki, T., Heissmeyer, V. and Krappmann, D. Dephosphorylation of Carma1 by PP2A negatively regulates T cell activation. (accepted) EMBO J.

2010

  • Glasmacher, E., Hoefig, K. P., Vogel, K. U., Rath, N., Du, L., Wolf, C., Kremmer, E., Wang, X., Heissmeyer, V. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. (2010) Nat Immunol. 11, 725-33. [PubMed Abstract...]

  • Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M. A., Lu, R., Ansel, K. M., Heissmeyer, V., Einav, S., Jackson, W., Doukas, T., Paranjape, S., Polacek, C., dos Santos, F. B., Jalili, R., Babrzadeh, F., Gharizadeh, B., Grimm, D., Kay, M., Koike, S., Sarnow, P., Ronaghi, M., Ding, S. W., Harris, E., Chow, M., Diamond, M. S., Kirkegaard, K., Glenn, J. S., Fire, A. Z. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. (2010) PLoS Pathog. 6, e1000764. [PubMed Abstract...]

2008

  • Ansel, K. M., Pastor, W. A.*, Rath, N.*, Lapan, A. D.*, Glasmacher, E., Wolf, C., Smith, L. C., Papadopoulou, N., Lamperti, E. D., Tahiliani, M., Ellwart, J. W., Shi, Y., Kremmer, E., Rao, A., Heissmeyer, V. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. (2008) Nat Struct Mol Biol. 15, 523-30.(*equal contribution). [PubMed Abstract Ansel....]

2007

  • Hölzel, M., Rohrmoser, M., Orban, M., Homig, C., Harasim, T., Malamoussi, A., Gruber-Eber, A., Heissmeyer, V., Bornkamm, G., Eick, D. Rapid conditional knock-down-knock-in system for mammalian cells. (2007) Nucleic Acids Res. 35, e17. .[PubMed Abstract Hölzel...]

2006

  • Wu, Y.*, Borde, M.*, Heissmeyer, V.*, Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., Mathis, D., Benoist, C., Chen, L., Rao, A. FOXP3 controls regulatory T cell function through cooperation with NFAT. (2006) Cell. 126, 375-87. (*equal contribution). .[PubMed Abstract Wu...]

  • Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T. W., Ruland, J., Heissmeyer, V., Krappmann, D. Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. (2006) Mol Cell. 23, 13-23. [PubMed Abstract Wegener....]

2005

  • Oberdoerffer, P., Kanellopoulou, C., Heissmeyer, V., Paeper, C., Borowski, C., Aifantis, I., Rao, A., Rajewsky, K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. (2005) Mol Cell Biol. 25, 3896-905. [PubMed Abstract Oberdoerffer....]

2004

  • Heissmeyer, V., Macian, F., Im, S. H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y. C., Dustin, M. L., Rao, A. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. (2004) Nat Immunol. 5, 255-65. [PubMed Abstract Heissmeyer V., Macian....]

  • Scharschmidt, E., Wegener, E., Heissmeyer, V., Rao, A., Krappmann, D. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. (2004) Mol Cell Biol. 24, 3860-73. [PubMed Abstract Scharschmidt...]

  • Kobori, M., Yang, Z., Gong, D., Heissmeyer, V., Zhu, H., Jung, Y. K., Gakidis, M. A., Rao, A., Sekine, T., Ikegami, F., Yuan, C., Yuan, J., Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. (2004) Cell Death Differ. 11, 123-30. [PubMed Abstract...]

2001

  • Krappmann, D., Patke, A., Heissmeyer, V., Scheidereit, C. B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's. (2001) Mol Cell Biol. 21, 6640-50.[PubMed Abstract ...]

  • Muller, D. N.*, Heissmeyer, V.*, Dechend, R., Hampich, F., Park, J. K., Fiebeler, A., Shagdarsuren, E., Theuer, J., Elger, M., Pilz, B., Breu, V., Schroer, K., Ganten, D., Dietz, R., Haller, H., Scheidereit, C., Luft, F. C. Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage. (2001) FASEB J. 15, 1822-4. (*equal contribution) [PubMed Abstract...]

  • Muller, D. N.*, Heissmeyer, V.*, Dechend, R., Hampich, F., Park, J. K., Fiebeler, A., Shagdarsuren, E., Theuer, J., Elger, M., Pilz, B., Breu, V., Schroer, K., Ganten, D., Dietz, R., Haller, H., Scheidereit, C., Luft, F. C. Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage. (2001) FASEB J. 15, 1822-4. (*equal contribution) [PubMed Abstract...]

2000

  • Kordes, U., Krappmann, D., Heissmeyer, V., Ludwig, W. D., Scheidereit, C. Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. (2000) Leukemia. 14, 399-402. [PubMed Abstract...]

1999

  • Heissmeyer, V., Krappmann, D., Wulczyn, F. G., Scheidereit, C. NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. (1999). EMBO J. 18, 4766-78. [PubMed Abstract Heissmeyer, V., Krappmann, D....]

  • Dechend, R., Hirano, F., Lehmann, K., Heissmeyer, V., Ansieau, S., Wulczyn, F. G., Scheidereit, C., Leutz, A. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (1999) Oncogene. 18, 3316-23.[PubMed Abstract ...]

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