Alumni

Dr. Gitta Heinz
PhD student


Project description:

Identification and analysis of mRNAs targeted by Roquin in T cells

Publications

  • Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V. Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity. 2013 Apr 18; 38(4): 655-68

  • Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11;210(2):417-32

  • Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan; 20(1): 73-81

  • Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol. 2010 Nov;11(11): 1057-62

  • Pannicke U, Hönig M, Schulze I, Rohr J, Heinz GA, Braun S, Janz I, Rump EM, Seidel MG, Matthes-Martin S, Soerensen J, Greil J, Stachel DK, Belohradsky BH, Albert MH, Schulz A, Ehl S, Friedrich W, Schwarz K. The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events. Hum Mutat. 2010 Feb;31(2):197-207

Curriculum Vitae

2011-2013PhD Fellowship of the Boehringer Ingelheim Fonds
since Sept 2010PhD student with Dr. Vigo Heissmeyer, Institute of Molecular Immunology, Helmholtz Zentrum München
Jan – Jun 2010Research fellow with Prof. PhD Gunnar Nilsson, Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, Stockholm
Apr – Dec 2009Master’s thesis with Prof. Dr. Andreas Radbruch, Cell Biology, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin
2007 – 2010Master’s program in Molecular Medicine, Charité Universitätsmedizin Berlin
Apr – Jul 2007Bachelor’s thesis with Dr. Klaus Schwarz, Molecular Diagnostics, Molecular Therapy and Experimental Transplantation, Institut für klinische Transfusion und Immungenetik Ulm (IKT)
2005 – 2009Scholarship of the German National Academic Foundation
2004 – 2007Bachelor’s program in Molecular Medicine, University of Ulm