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The impact of an altered thiol-linked redox homeostasis on cellular physiology and on the pathogenesis of inherited and environmental disease

M. Brielmeier, C. Kiermayer

Thioredoxin reductases (TXNRDs) are part of the thioredoxin-dependent redoxsystem. Its main function is the maintenance of the cellular redox homeostasis under a changing environment. The range of cellular processes being controlled by redox regulation is broad, including e.g. signal transduction or the decision on cell proliferation, quiescence or death. The tight control of the cellular redox environment is essential for normal physiological function and its persisting alteration is characteristic for many pathological conditions.

At present, using mouse models, we study the influence of the muscle-specific Txnrd2 knockout on the function of skeletal muscle under normal physiological conditions and on emerging chronic effects. Muscle weakness and wasting has been described for disorders like diabetes, obesity and several mitochondrial disorders. Due to its high energy demand skeletal muscle has the potential to modulate systemic metabolism, therefore our special attention focuses on the energy metabolism of skeletal muscle and its possible impact on systemic metabolism.

Moreover we aim at strategies for prevention and cure.