Scope

T cell activation by an antigen presenting cells (APC).
T cell activation by an antigen presenting cells (APC).

Antigens are presented to T cells by antigen presenting cells (APCs). Antigen binding to the T cell receptor (TCR) in conjunction with an appropriate co-stimulus (e.g. generated by CD28 receptor) induces a transcriptional program that promotes cytokine secretion (e.g. IL-2), survival and clonal expansion of naïve CD4 + T cells. Primary T cell activation requires activation of transcription factors NF-AT (Nuclear factor of activated T cells), AP-1 (Activator protein 1) and NF-κB.

In the group we study cellular signaling pathways that govern IKK/NF-κB activation in lymphocytes. By biochemical and molecular biological techniques, we analyze the regulatory interactions between multi-protein complexes that form in response to lymphocyte activation. Complex formation between Carma1, Bcl10 and Malt1 (CBM complex) constitutes a major platform for lymphocyte activation and multiple positive and negative regulatory pathways impinge on this complex. These processes involve phosphorylation as well as ubiquitin and ubiquitin-like modifications.

Activation of IKK/NF-κB signaling in response to TCR/CD28 co-engagement.
Activation of IKK/NF-κB signaling in response to TCR/CD28 co-engagement.