Research

„Translation“ and „prevention“ are the leading concepts for the work of the Institute for Asthma and Allergy Prevention.
Within the topic  “translation” all analyses of OMICS data which have been generated by the ALLIANCE cohort of the German Center for Lung Research focus on the following questions:

  • What are the molecular signatures of the “transient wheeze” phenotype
  • What are the molecular signatures of the “late onset” phenotype
  • What are the molecular signatures of the “persistent wheeze” phenotype
  • What are the molecular signatures of the “intermediate wheeze” phenotype
  • What are the molecular signatures of remission in early childhood
  • What are the molecular signatures of remission at school age
  • What are the molecular signatures of progression
  • What are the molecular signatures of chronification
  • What are the targets for a personalized therapy of specific asthma phenotypes?
  • What are the targets for a personalized secondary prevention?

The research which is dedicated to “prevention” mainly comprises the analyses of the microbial data from the farm studies, pursuing especially the following questions:

  • Which are the specific microorganisms that protect from asthma?
  • Which are the microorganisms that protect from hay fever?
  • Which are the microorganisms that protect from allergic sensitization?
  • Which are the relevant metabolites of these microorganisms?
  • Do only the metabolites have the protective effect on asthma, hay fever and atopy?
  • Which combinations of probiotics are necessary for primary prevention?
  • Which application form (perorally, by inhalation) is adequate for such probiotics