Projects terminated

DIAB-CARE:  Economics and Health Care Research  in Type 2 Diabetes Mellitus - 
Health-Related Quality of Life (HRQL)(Subproject 24a, Module 3) 
Investigators:Prof. R. Holle (PI), Dr. M. Schunk, Dr. P. Reitmeir
Funded by:BMBF  (German Federal Ministry of Education and Research)
Duration:12/2011- 01/2014
Description:The project belongs to the topic area “Economics and Health Care Research in Type 2 Diabetes Mellitus”. It is part of research carried out within the “Competence Network Diabetes” (phase 2), funded by the BMBF.

In the first funding period of the “Competence Network Diabetes” (2008-2011), a large pooled sample from six population-based German survey studies comprising more than 30.000 subjects (est. 1800 subjects with prevalent T2DM) was established as part of the Diabetes-Collaborative Research of Epidemiologic Studies (DIAB-CORE) research consortium.

These cross-sectional analyses are now continued under a longitudinal perspective. In particular, follow-up data after 6 years on average are available and will be analyzed.
Objectives:Within subproject 24a, module 3, this project is in charge of the following research question:  
  • Health-Related Quality of Life (HRQL) in T2DM

Patient-reported outcomes such as HRQL are essential for the evaluation of cost-effectiveness of innovative drugs or treatment interventions as well as for model based cost-utility analysis. With the longitudinal analysis of pooled data from several population- based studies across Germany (KORA S4-F4 (Augsburg); SHIP 0-SHIP 2 (Greifswald); CARLA -CARLA  Follow-up (Halle); BGS98 – DEGS1 (nationwide)), it is aimed to provide a reference set of German HRQL values for T2DM in different stages of the disease and in patient subgroups.

Research questions:

  1. How does longitudinal change in HRQL in a population-based sample of type 2 diabetic patients in Germany differ from that in healthy controls and in incident cases?
  2. Which factors influence longitudinal change in HRQL in type 2 diabetic patients (e.g. comorbid conditions as well as changes in BMI and HbA1c)?
  3. Is adequate antidiabetic and cardiovascular medication of diabetes patients associated with improved HRQL?
Methods:The pooled dataset from the first funding period contains HRQL data from five studies with comparable study design. Follow-up data are available in four studies.  Quality of life was assessed by the Health Survey Short Form (SF12, SF36), a generic index instrument for HRQL. Further variables available include a range of disease-specific information as well as information on socioeconomic status, medication, life-style factors and micro- and macrovascular morbidity and mortality. After pooling of baseline and follow-up data, we will assess changes in HRQL values of T2DM patients and compare them with those of non-diabetic subjects.  The association of HRQL with other factors will be analysed using multiple regression models.