Completed projects

Diabetes-Collaborative Research of Epidemiologic Studies (DIAB-CORE) Subproject 2 (Economics and Health Care Research): Health-Related Quality of Life (HRQoL) in Type 2 Diabetes Mellitus
Investigators:Prof. R. Holle (PI), Dr. M. Schunk, Dr. P. Reitmeir
Funded by:BMBF (German Federal Ministry for Education and Research)
Duration:12/2008 - 11/2011
Description:The project belongs – as part of subproject 2 - to the research consortium „Diabetes-Collaborative Research of Epidemiologic Studies“(DIAB-CORE), one of seven research groups affiliated to the “Competence Network Diabetes” funded by the BMBF. Main goal of the DIAB-CORE consortium is to establish a large pooled sample from six population-based German survey studies comprising more than 30.000 subjects (est. 1800 subjects with prevalent T2DM) for economic evaluation and health care research in type 2 diabetes mellitus (T2DM).
Objectives:Within subproject 2, this project is in charge of the following research question:
 
  • Health-Related Quality of Life (HRQoL) in T2DM
Patient-reported outcomes such as HRQoL are essential for the evaluation of cost-effectiveness of innovative drugs or treatment interventions as well as for model based cost-utility analysis. With the pooled data of several population- based studies across Germany, it is aimed to provide a reference set of German HRQoL values for T2DM in different stages of the disease and in patient subgroups.
Methods:The pooled data set contains variables on health care utilisation, HRQoL, medication, co-morbidities as well as a range of disease-specific information and basic variables age, sex and socioeconomic position. Quality of life was assessed by the Health Survey Short Form (SF12, SF36), a generic index instrument for HRQoL. In all six studies, the same or similar instruments were used. Based on a comprehensive analysis of the pooled data, HRQoL utility values of T2DM patients will be calculated and compared with those of non-diabetic subjects.  The association of HRQoL with other factors will be analysed using multiple regression models.
Publications:

Schunk, M., Reitmeir, P., Schipf, S., Völzke, H., Meisinger, C., Thorand, B., Kluttig, A., Greiser, K.H., Berger, K., Müller, G., Ellert, U., Neuhauser, H., Tamayo, T., Rathmann, W., Holle, R.: Health-related quality of life in subjects with and without type 2 diabetes: pooled analysis of five population-based surveys in Germany. Diabetic Medicine) 29:646-653 (2012)

Schunk, M., Reitmeir, P., Schipf, S., Völzke, H., Meisinger, C., Rückert, I.M., Kluttig, A., Greiser, K.H., Berger, K., Müller, G., Ellert, U., Neuhauser, H., Tamayo, T., Rathmann, W., Holle, R.: Die Bedeutung des Typ 2 Diabetes für die gesundheitsbezogene Lebensqualität – Ergebnisse aus bevölkerungsbasierten  Studien in Deutschland (DIAB-CORE Verbund). Med. Welt 63, 263-268 (2012)

 

Schunk, M., Reitmeir, P., Schipf, S., Völzke, H., Meisinger, C., Ladwig, K.-H., Kluttig, A., Greiser, K.H., Berger, K., Müller, G., Ellert, U., Neuhauser, H., Tamayo, T., Rathmann, W., Holle, R.: Health-related quality of life in women and men with type 2 diabetes: a comparison across treatment groups. Journal of Diabetes and Its Complications 29(2), 203-211 (2015)