Projects terminated

KORINNA - A case management intervention for aged patients with myocardial infarction
Head/
Team:
Prof. Dr. R. Holle,
Dr. H. Seidl, Dr. B. Stollenwerk, Dr. M. Hunger, H. Hänsch
Funding:Federal Ministry of Education and Health
FKZ 01 ET 0713
Duration:3 years
ISRCTN Register NoISRCTN02893746
Description:The randomized study compares case management for elderly people with acute myocardial infarction admitted to hospital with standard care. Our institute is responsible for the economic evaluation of the study, data management and statistical analysis.
Objective:The main research hypothesis is that for patients aged 65 years and older with a myocardial infarction a case management can reduce the rehospitalization rate (primary outcome) and improve the clinical outcome parameters (secondary outcome). The intervention will be accompanied by a cost-utility analysis.
Method:The intervention group will be compared with a control group with regard to several outcome measures. Patients in the intervention group will be offered a case management program. Case management includes telephone calls and home visits by a trained nurse. Patients in the control group receive standard care. Patients will be randomized at study entry (balanced by age, sex and comorbidities).

A number of 340 patients have been recruited from September 2008 to May 2010.

Data will be collected at study entry during hospital stay, after one year and after three years in the hospital by a practitioner. Additionally, patients will be interviewed within a computer-aided telephone interview (CATI) every three months in the first year and annual in the second and third year.

Publications:

Seidl H, Hunger M, Meisinger C, Kirchberger I, Kuch B, Leidl R, Holle R. The 3-Year Cost-Effectiveness of a Nurse-Based Case Management versus Usual Care for Elderly Patients with Myocardial Infarction: Results from the KORINNA Follow-Up Study. Value in Health, 2016, DOI: 10.1016/j.jval.2016.10.001

Seidl H, Meisinger C, Kirchberger I, Burkhardt K, Kuch B, Holle R. Validity of self-reported hospital admissions in clinical trials depends on recall period length and individual characteristics. Journal of Evaluation in Clinical Practice, 2015 Dec 29. doi: 10.1111/jep.12506. [Epub ahead of print]

Kirchberger, I., Meisinger C., Seidl, H., Wende, R., Kuch, B., Holle, R.: Nurse-based case management for aged patients with myocardial infarction: study protocol of a randomized controlled trial. BMC Geriatrics, 10:29(2010) 

Peters, A., et al.: [Multimorbidity and successful aging: the population-based KORA-Age study]. Z Gerontol Geriatr 44 Suppl 2, 41-54 (2011). 

Meisinger, C. et al.: Effects of a nurse-based case management compared to usual care among aged patients with myocardial infarction: results from the randomized controlled KORINNA study. BMC Geriatr 13(1), 115 (2013). 

Hunger, M. et al.: Does nurse-based case management for aged myocardial infarction patients improve risk factors, physical functioning and mental health? The KORINNA trial. European journal of preventive cardiology (2014). 

Quinones, P.A. et al.: New potential determinants of disability in aged persons with myocardial infarction: results from the KORINNA-study. BMC Geriatr 14, 34 (2014). 

Al-Khadra, S. et al.: Secondary prevention medication after myocardial infarction: persistence in elderly people over the course of 1 year. Drugs Aging 31(7), 513-525 (2014). 

Kirchberger I. et al.: A 3-year nurse-based case management in aged patients with acute myocardial infarction improved functional status and malnutrition risk, but failed to affect rehospitalisation and mortality. PLOS One (2015)

Seidl, H. et al.: Empirical analysis shows reduced cost data collection may be an efficient method in economic clinical trials. BMC Health Serv Res 12, 318 (2012).                                                                   
Seidl, H. et al.: Cost-effectiveness of nurse-based case management versus usual care for elderly patients with myocardial infarction: results from the KORINNA study. Eur J Health Econ (2014).