Current projects


MobilE-TRA2: Behavioural and patient-individual determinants of quality of life, functioning and physical activity in older adults

Principal investigatorsProf. Dr. Eva Grill, MPH; Institute for Medical Information Processing, Biometry and Epidemiology (IBE) and German Center for Vertigo and Balance Disorders, LMU München
PD Dr. Lars Schwettmann; Institute of Health Economics and Health Care Management, Helmholtz Zentrum München
PD Dr. med. Martin Weigl, Dr. med Alexander Paulus; Department of Orthopaedics, Physical Medicine and Rehabilitation, Hospital of the Ludwig-Maximilians-University, LMU München
Project sponsor   BMBF (FKZ 01GY1913B)
Duration 36 months; until May 31, 2023
Co.operation partner• Department of Orthopaedics, Physical Medicine and Rehabilitation (OPMR), LMU München
• German Centre for Vertigo and Balance Disorders (DSGZ), LMU München
• KORA study Augsburg
Aim of the projectThe aim of MobilE-TEA2 is:
• To investigate the behavioural, individual determinants of functioning, physical activity and quality of life after total hip or knee replacement (THR/TKR) and after interdisciplinary assessment of vertigo, dizziness and balance problems (VDB)
• To identify risk groups with a special focus on non-adherence
• To provide guidance for clinical care pathways
Thematic focus    Mobility, functioning and quality of life in older adults: behavioural, patientindividual determinants and barriers
Study typeLongitudinal cohort study, secondary data analysis
Methods• Data collection in two specialized tertiary care centers, postal follow-ups
• Comparison with age-and sex-matched general population
• Regression and moderation analyses to examine predictors and effect modifiers
Target and study population, sample sizePatients aged 60 and older presenting at the participating centers: 154 patients undergoing first THR/TKR, 324 patients with Benign Paroxysmal Positional Vertigo, Menière’s disease, vestibular migraine, and functional vertigo after interdisciplinary assessment of VDB, 3000 participants in a population-based cohort study
SummaryOsteoarthritis leading to joint replacement and VDB are among the major reasons for mobility limitations in older adults. However, predominantly in older adults, THR/TKR or VDB evaluation fails to achieve mobility and participation goals. MobilE-TRA2 will conduct an observational, longitudinal cohort study with patients undergoing joint replacement and patients with VDB after interdisciplinary. Based on insights from behavioural economics (BE), we will investigate determinants of quality of life, functioning and physical activity during discharge and rehabilitation planning and during aftercare. Special attention will be payed to motivation for adherence to recommendations, self-efficacy and risk and time preferences of the patients as relevant BE concepts.
Outcome variables• Primary: generic health related quality of life, disease-specific functioning
• Secondary: physical activity, adherence
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