Publications

Dawidowski, M. ; Kalel, V.C. ; Napolitano, V. ; Fino, R. ; Schorpp, K.K. ; Emmanouilidis, L. ; Lenhart, D. ; Ostertag, M.S. ; Kaiser, M. ; Kolonko, M. ; Tippler, B. ; Schliebs, W. ; Dubin, G. ; Mäser, P. ; Tetko, I.V. ; Hadian, K. ; Plettenburg, O. ; Erdmann, R. ; Sattler, M. ; Popowicz, G.M.

Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity.

J. Med. Chem. 63, 847-879 (2020)

Laitinen, I. ; Jones, S. ; Derdau, V. ; Eriksson, O. ; Haack, T.B. ; Johansson, L. ; Larsen, P. ; Loewe, C. ; Pierrou, S. ; Plettenburg, O. ; Schudok, M. ; Velikyan, I. ; Wagner, M.

Assessment of in vivo glucagon receptor engagement in rat liver.

Eur. J. Nucl. Med. Mol. Imaging 46, S707-S708 (2019)

Eriksson, O. ; Velikyan, I. ; Haack, T. ; Bossart, M. ; Evers, A. ; Laitinen, I. ; Larsen, P.J. ; Plettenburg, O. ; Takano, A. ; Halldin, C. ; Antoni, G. ; Johansson, L. ; Pierrou, S. ; Wagner, M.

Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates.

Sci. Rep. 9:14960 (2019)

Kniggendorf, A.K. ; Schmidt, D. ; Roth, B. ; Plettenburg, O. ; Zeilinger, C.

pH-dependent conformational changes of KcsA tetramer and monomer probed by raman spectroscopy.

Int. J. Mol. Sci. 20:2736 (2019)

Ostertag, M.S. ; Hutwelker, W. ; Plettenburg, O. ; Sattler, M. ; Popowicz, G.M.

Structural insights into BET client recognition of endometrial and prostate cancer-associated SPOP mutants.

J. Mol. Biol. 431, 2213-2221 (2019)

Plettenburg, O.

The impact of chemical biology on drug discovery.

Isr. J. Chem. 59, 29-36 (2019)

Velikyan, I. ; Haack, T. ; Bossart, M. ; Evers, A. ; Laitinen, I. ; Larsen, P. ; Plettenburg, O. ; Johansson, L. ; Pierrou, S. ; Wagner, M. ; Eriksson, O.

First-in-class positron emission tomography tracer for the glucagon receptor.

EJNMMI Res. 9:17 (2019)

Plettenburg, O.

Milestones in bioorganic chemistry.

ChemBioChem 20, 129-130 (2019)

Kyriakou, E. ; Schmidt, S. ; Dodd, G.T. ; Pfuhlmann, K. ; Simonds, S.E. ; Lenhart, D. ; Geerlof, A. ; Schriever, S.C. ; de Angelis, M. ; Schramm, K.-W. ; Plettenburg, O. ; Cowley, M.A. ; Tiganis, T. ; Tschöp, M.H. ; Pfluger, P.T. ; Sattler, M. ; Messias, A.C.

Celastrol promotes weight loss in diet-induced obesity by inhibiting the protein tyrosine phosphatases PTP1B and TCPTP in the hypothalamus.

J. Med. Chem. 61, 11144-11157 (2018)

Hadian, K. ; Brenke, J.K. ; Plettenburg, O. ; Jürjens, G.

Preparation of triazolopyridazinyl and imidazopyridazinyl pyrazoles as TRAF 6 inhibitors.

Schutzrecht WO 2018050286 (2018)

Duro-Castano, A. ; Lim, N.H. ; Tranchant, I. ; Amoura, M. ; Beau, F. ; Wieland, H. ; Kingler, O. ; Hermann, M. ; Nazaré, M. ; Plettenburg, O. ; Dive, V. ; Vicent, M.J. ; Nagase, H.

In vivo imaging of MMP-13 activity using a specific polymer-FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy.

Adv. Func. Mat. 28:1802738 (2018)

Jürjens, G. ; Schuler, S.M.M. ; Kurz, M. ; Petit, S. ; Couturier, C. ; Jeannot, F. ; Nguyen, F. ; Wende, R.C. ; Hammann, P.E. ; Wilson, D.N. ; Bacqué, E. ; Pöverlein, C. ; Bauer, A.

Total synthesis and structural revision of the antibiotic tetrapeptide GE81112A.

Angew. Chem.-Int. Edit. 57, 12157-12161 (2018)

Brenke, J.K. ; Popowicz, G.M. ; Schorpp, K.K. ; Rothenaigner, I. ; Roesner, M. ; Meininger, I. ; Kalinski, C. ; Ringelstetter, L. ; R'kyek, O. ; Jürjens, G. ; Vincendeau, M. ; Plettenburg, O. ; Sattler, M. ; Krappmann, D. ; Hadian, K.

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.

J. Biol. Chem. 293, 13191-13203 (2018)

Yue, Q. ; Stahl, F.R. ; Plettenburg, O. ; Kirschning, A. ; Warnecke, A. ; Zeilinger, C.

The noncompetitive effect of gambogic acid displaces fluorescence-labeled ATP but requires ATP for binding to Hsp90/HtpG.

Biochemistry 57, 2601-2605 (2018)

Haack, T. ; Plettenburg, O. ; Wagner, M. ; Bossart, M. ; Betrand, R.

Selective glucagon receptor agonists comprising a chelating moiety for imaging purposes.

Schutzrecht WO 2017/102613 A1 (2017)

Petry, S. ; Plettenburg, O. ; Tennagels, N. ; Werner, U.

Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein.

Schutzrecht WO 2017/207754 A1 (2017)

Eriksson, O. ; Bossart, M. ; Haack, T.B. ; Laitinen, I. ; Larsen, P. ; Plettenburg, O. ; Johansson, L. ; Pierrou, S. ; Wagner, M. ; Velikyan, I.

First-in-class PET tracer for the glucagon receptor.

Diabetologia 60, S400-S400 (2017)

Yusubov, M.S. ; Postnikov, P.S. ; Yusubova, R.Y. ; Yoshimura, A. ; Jürjens, G. ; Kirschning, A.

2-iodoxybenzoic acid tosylates: The alternative to dess–Martin periodinane oxidizing reagents.

Adv. Synth. Catal. 359, 3207-3216 (2017)

Keipert, S. ; Kutschke, M. ; Ost, M. ; Schwarzmayr, T. ; van Schothorst, E.M. ; Lamp, D. ; Brachthäuser, L. ; Hamp, I. ; Mazibuko-Mbeje, S. ; Hartwig, S. ; Lehr, S. ; Graf, E. ; Plettenburg, O. ; Neff, F. ; Tschöp, M.H. ; Jastroch, M.

Long-term cold adaptation does not require FGF21 or UCP1.

Cell Metab. 26, 437-446.e5 (2017)

Li, J. ; Chu, M.K. ; Lu, B. ; Mirzaie, S. ; Chen, K. ; Gordijo, C.R. ; Plettenburg, O. ; Giacca, A. ; Wu, X.Y.

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices.

Drug Deliv. Transl. Res. 7, 529-543 (2017)

Plettenburg, O.

What do reactive fragments actually do in cells?

Angew. Chem.-Int. Edit. 56, 446-448 (2017)

Bertrand, R. ; Wagner, M. ; Derdau, V. ; Plettenburg, O.

Mild and selective mono-iodination of unprotected peptides as initial step for the synthesis of bioimaging probes.

Bioconjug. Chem. 27, 2281-2286 (2016)

Bertrand, R. ; Hamp, I. ; Brönstrup, M. ; Weck, R. ; Lukacevic, M. ; Polyak, A. ; Ross, T.L. ; Gotthardt, M. ; Plettenburg, O. ; Derdau, V.

Synthesis of GPR40 targeting ³H- and ¹⁸F-probes towards selective beta cell imaging.

J. Labelled Comp. Radiopharm. 59, 604-610 (2016)

Bertrand, R. ; Wolf, A. ; Ivashchenko, Y. ; Löhn, M. ; Schäfer, M. ; Brönstrup, M. ; Gotthardt, M. ; Derdau, V. ; Plettenburg, O.

Synthesis and characterization of a promising novel FFAR1/GPR40 targeting fluorescent probe for β-cell imaging.

ACS Chem. Biol. 11, 1745-1754 (2016)

Hu, H.Y. ; Nazare, M. ; Han Lim, N. ; Ding-Pfennigdorff, D. ; Plettenburg, O. ; Ritzeler, O. ; Juretschke, H.P. ; Saas, J. ; Bartinek, E. ; Florian, P. ; Wendt, U. ; Schultz, C. ; Nagase, H.

DOTAM derivatives for therapeutic use.

Schutzrecht WO 2015075699 (2015)

Hu, H.Y. ; Lim, N.H. ; Ding-Pfennigdorff, D. ; Saas, J. ; Wendt, K.U. ; Ritzeler, O. ; Nagase, H. ; Plettenburg, O. ; Schultz, C. ; Nazare, M.

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

Bioconjug. Chem. 26, 383-388 (2015)

Li, J. ; Chu, M.K. ; Gordijo, C.R. ; Abbasi, A.Z. ; Chen, K. ; Adissu, H.A. ; Löhn, M. ; Giacca, A. ; Plettenburg, O. ; Wu, X.Y.

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

Biomaterials 47, 51-61 (2015)

Löhn, M. ; Plettenburg, O. ; Kannt, A. ; Kohlmann, M. ; Hofmeister, A. ; Kadereit, D. ; Monecke, P. ; Schiffer, A. ; Schulte, A. ; Ruetten, H. ; Ivashchenko, Y.

End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899.

World J. Cardiol. 7, 31-42 (2015)

Chu, M.K. ; Gordijo, C.R. ; Li, J. ; Abbasi, A.Z. ; Giacca, A. ; Plettenburg, O. ; Wu, X.Y.

In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery.

Diabetes Technol. Ther. 17, 255-267 (2015)

Plettenburg, O. ; Löhn, M.

In vivo imaging of drug action.

In: Czechtizky, W.* ; Hamley, P.* [Eds.]: Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell, 2015. 465-501

Hu, H.Y. ; Vats, D. ; Vizovisek, M. ; Krämer, L. ; Germanier, C. ; Wendt, K.U. ; Rudin, M. ; Turk, B. ; Plettenburg, O. ; Schultz, C.

In vivo imaging of mouse tumors by a lipidated cathepsin S substrate.

Angew. Chem.-Int. Edit. 53, 7669-7673 (2014)

Hu, H.Y. ; Gehrig, S. ; Reither, G. ; Subramanian, D. ; Mall, M.A. ; Plettenburg, O. ; Schultz, C.

FRET-based and other fluorescent proteinase probes.

Biotechnol. J. 9, 266-281 (2014)

Grisk, O. ; Koenen, A. ; Meissner, T. ; Donner, A. ; Braun, D. ; Steinbach, A. ; Glöckl, G. ; Zimmermann, U. ; Evert, K. ; Evert, M. ; Katsari, E. ; Löhn, M. ; Plettenburg, O. ; Rettig, R.

Rho kinase inhibition mitigates sunitinib-induced rise in arterial pressure and renal vascular resistance but not increased renal sodium reabsorption.

J. Hypertens. 32, 2199-2210 (2014)

Babelova, A. ; Jansen, F. ; Sander, K. ; Löhn, M. ; Schäfer, L. ; Fork, C. ; Ruetten, H. ; Plettenburg, O. ; Stark, H. ; Daniel, C. ; Amann, K. ; Pavenstädt, H. ; Jung, O. ; Brandes, R.P.

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.

PLoS ONE 8:e80328 (2013)

Grisk, O. ; Schlüter, T. ; Reimer, N. ; Zimmermann, U. ; Katsari, E. ; Plettenburg, O. ; Löhn, M. ; Wollert, H.G. ; Rettig, R.

The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries.

J. Hypertens. 30, 980-989 (2012)

McNicholas, T.P. ; Yum, K. ; Ahn, J.H. ; Mu, B. ; Plettenburg, O. ; Gooderman, A. ; Natesan, S. ; Strano, M.S.

Structure and function of glucose binding protein-single walled carbon nanotube complexes.

Small 8, 3510-3516 (2012)

Löhn, M. ; Plettenburg, O. ; Ivashchenko, Y. ; Kannt, A. ; Hofmeister, A. ; Kadereit, D. ; Schaefer, M. ; Linz, W. ; Kohlmann, M. ; Herbert, J.M. ; Janiak, P. ; O'Connor, S.E. ; Ruetten, H.

Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.

Hypertension 54, 676-683 (2009)

Plettenburg, O. ; Lorenz, K. ; Loehn, M. ; Duclos, O. ; Biscarrat, S.

Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors.

Schutzrecht WO/2009/156092 (2009)

Plettenburg, O. ; Lorenz, K. ; Loehn, M. ; Weston, J. ; Kleemann, H.-W.

6-substituted isoquinolines and isoquinolinones.

Schutzrecht WO/2009/156099 (2009)

Bickel, M. ; Brummerhop, H. ; Frick, W. ; Glombik, H. ; Herling, A.W. ; Heuer, H.O. ; Plettenburg, O. ; Theis, S. ; Werner, U. ; Kramer, W.

Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats.

Arzneim. Forsch. 58, 574-580 (2008)

Plettenburg, O. ; Lorenz, K. ; Goerlitzer, J. ; Löhn, M. ; Biscarrat, S. ; Jeannot, F. ; Duclos, Ol

Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives.

Schutzrecht WO/2008/077556 (2008)

Plettenburg, O. ; Hofmeister, A. ; Brendel, J. ; Löhn, M.

Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase.

Schutzrecht WO/2008/077550 (2008)

Plettenburg, O. ; Hofmeister, A. ; Goerlitzer, J. ; Löhn, M.

Substituted isoquinoline and isoquinolinone derivatives.

Schutzrecht WO/2008/077552 (2008)

Plettenburg, O. ; Hofmeister, A. ; Goerlitzer, J. ; Löhn, M.

Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives.

Schutzrecht WO/2008/077553 (2008)

Plettenburg, O. ; Hofmeister, A. ; Kadereit, D. ; Peukert, S. ; Ruf, S. ; Löhn, M. ; Monecke, P. ; Schiffer, A. ; Kannt, A. ; Kohlmann, M.

Cycloalkylamine substituted isoquinoline derivatives

Schutzrecht WO/2008/077554 (2008)

Plettenburg, O. ; Hofmeister, A. ; Lorenz, K. ; Brendel, J. ; Löhn, M. ; Weston, J.

Cycloalkylamine substituted isoquinolone derivatives.

Schutzrecht WO/2008/077551 (2008)

Plettenburg, O. ; Lorenz, K. ; Goerlitzer, J. ; Löhn, M.

Substituted isoquinolines and their use as rho-kinase inhibitors

Schutzrecht WO/2008/077555 (2008)

Plettenburg, O. ; Hofmeister, A. ; Kadereit, D. ; Peukert, S. ; Ruf, S. ; Ritter, K. ; Löhn, M. ; Ivashchenko, Y. ; Monecke, P. ; Dreyer, M. ; Kannt, A.

Isoquinoline derivatives as inhibitors of rho-kinase.

Schutzrecht WO/2007/000240 (2007)

Plettenburg, O. ; Hofmeister, A. ; Kadereit, D. ; Brendel, J. ; Loehn, M.

Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors.

Schutzrecht WO/2007/012422 (2007)

Plettenburg, O. ; Hofmeister, A. ; Kadereit, D. ; Brendel, J. ; Loehn, M.

Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors.

Schutzrecht WO/2007/012421 (2007)

Steioff, K. ; Rütten, H. ; Busch, A.E. ; Plettenburg, O. ; Ivashchenko, Y. ; Löhn, M.

Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.

Eur. J. Pharmacol. 512, 247-249 (2005)

Wu, D. ; Xing, G.W. ; Poles, M.A. ; Horowitz, A. ; Kinjo, Y. ; Sullivan, B. ; Bodmer-Narkevitch, V. ; Plettenburg, O. ; Kronenberg, M.F. ; Tsuji, M. ; Ho, D.D. ; Wong, C.H.

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.

Proc. Natl. Acad. Sci. U.S.A. 102, 1351-1356 (2005)

Podeschwa, M.A. ; Plettenburg, O. ; Altenbach, H.J.

Flexible stereo- and regioselective synthesis of myo-inositol phosphates (Part 2): Via nonsymmetrical conduritol B derivatives.

Eur. J. Org. Chem., 3116-3127 (2005)

Podeschwa, M.A. ; Plettenburg, O. ; Altenbach, H.J.

Flexible stereo- and regioselective synthesis of myo-inositol phosphates (Part 1): Via symmetrical conduritol B derivatives.

Eur. J. Org. Chem., 3101-3115 (2005)

Brummerhop, H. ; Frick, W. ; Glombik, H. ; Plettenburg, O. ; Bickel, M. ; Heuer, H. ; Theis, S.

Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof.

Schutzrecht WO/2005/121161 (2005)

Glombik, H. ; Frick, W. ; Heuer, H. ; Kramer, W. ; Brummerhop, H. ; Plettenburg, O.

Synthesis and therapeutic evaluation of thiophene glycosides for use in the treatment of diabetes or for lowering blood sugar levels.

Schutzrecht WO2004007517 A1 (2004)

Frick, W. ; Glombik, H. ; Kramer, W. ; Heuer, H. ; Brummerhop, H. ; Plettenburg, O.

Novel aromatic fluoroglycoside derivatives, pharmaceutical products containing said compounds and the use thereof.

Schutzrecht WO/2004/052902 (2004)

Frick, W. ; Glombik, H. ; Kramer, W. ; Heuer, H. ; Brummerhop, H. ; Plettenburg, O.

Novel fluoroglycoside heterocyclic derivatives, pharmaceutical products containing said compounds and the use thereof.

Schutzrecht WO/2004/052903 (2004)

Podeschwa, M.A. ; Plettenburg, O. ; Altenbach, H.J.

Stereoselective synthesis of several azido/amino- and diazido/diamino-myo-inositols and their phosphates from p-benzoquinone.

Org. Biomol. Chem. 1, 1919-1929 (2003)

Podeschwa, M.A. ; Plettenburg, O. ; vom Brocke, J. ; Block, O. ; Adelt, S. ; Altenbach, H.J.

Stereoselective synthesis of myo-, neo-, L-chiro, D-chiro, allo-, scyllo-, and epi-inositol systems via conduritols prepared from p-benzoquinone.

Eur. J. Org. Chem., 1958-1972 (2003)

Bryan, M.C. ; Plettenburg, O. ; Sears, P. ; Rabuka, D. ; Wacowich-Sgarbi, S. ; Wong, C.H.

Saccharide display on microtiter plates.

Chem. Biol. 9, 713-720 (2002)

Plettenburg, O. ; Bodmer-Narkevitch, V. ; Wong, C.H.

Synthesis of alpha-galactosyl ceramide, a potent immunostimulatory agent.

J. Org. Chem. 67, 4559-4564 (2002)

Plettenburg, O. ; Mui, C. ; Bodmer-Narkevitch, V. ; Wong, C.

Rapid preparation of glycolipid libraries by cross metathesis.

Adv. Synth. Catal. 344, 622-626 (2002)

Izumi, M. ; Shen, G.J. ; Wacowich-Sgarbi, S. ; Nakatani, T. ; Plettenburg, O. ; Wong, C.H.

Microbial glycosyltransferases for carbohydrate synthesis: alpha-2,3-sialyltransferase from Neisseria gonorrheae.

J. Am. Chem. Soc. 123, 10909-10918 (2001)

Adelt, S. ; Plettenburg, O. ; Dallmann, G. ; Ritter, F.P. ; Shears, S.B. ; Altenbach, H.J. ; Vogel, G.

Regiospecific phosphohydrolases from Dictyostelium as tools for the chemoenzymatic synthesis of the enantiomers D-myo-inositol 1,2,4-trisphosphate and D-myo-inositol 2,3,6-trisphosphate: non-physiological, potential analogues of biologically active D-myo-inositol 1,3,4-trisphosphate.

Bioorg. Med. Chem. Lett. 11, 2705-2708 (2001)

Adelt, S. ; Plettenburg, O. ; Stricker, R. ; Reiser, G. ; Altenbach, H.J. ; Vogel, G.

Enzyme-Assisted Total Synthesis of the Optical Antipodes D-myo-Inositol 3,4,5-Trisphosphate and D-myo-Inositol 1,5,6-Trisphosphate: Aspects of Their Structure-Activity Relationship to Biologically Active Inositol Phosphates.

J. Med. Chem. 42, 1262-1273 (1999)

Adelt, S. ; Plettenburg, O. ; Stricker, R. ; Reiser, G. ; Altenbach, H.J. ; Vogel, G.

Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates.

J. Med. Chem. 42, 1262-1273 (1999)

Plettenburg, O. ; Adelt, S. ; Vogel, G. ; Altenbach, H.J.

De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4-regiospecificity of their enzymatic dephosphorylation.

Tetrahedron Asymm. 11, 1057-1061 (1999)

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