Cell Programming & Repair

 

 

Research Unit Apoptosis in Hematopoetic Stem Cells (AHS)

Head: Prof. Dr. Irmela Jeremias
Mildred Scheel Research Professorship at Ludwig-Maximilians-Universität München

The vision of the Research Unit Apoptosis in Hematopoietic Stem Cells (AHS) is to develop novel anti-cancer treatment strategies that eliminate leukemia stem cells. We aim at discovering mechanisms that allow inducing apoptosis in tumor stem cells, in order to overcome treatment resistance and prevent disease relapse. Using genetically modified patients´ leukemia cells growing in mice, we search for cellular structures which represent effective novel targets for therapy.

to the AHS website

Institute of Developmental Genetics (IDG)

Director: Prof. Dr. Wolfgang Wurst
Chair of Developmental Genetics at Technische Universität München

The Institute of Developmental Genetics (IDG) focuses on the functional analysis of the mammalian genomes, the development of methods for such analysis and on the development of animal models for the analysis of the genome and the study of the pathogenesis of human diseases. The aim of this research is to investigate genetically determined diseases of the central nervous systems, the eye, and the skeletal system, and to elucidate the molecular mechanisms that control embryonal development.

To the IDG website

Institute of Diabetes- and Regeneration Research (IDR)

Director: Prof. Dr. Heiko Lickert
Chair of Diabetes Research / Beta Cell Biology at Technische Universität München

The Institute of Diabetes and Regeneration Research (IDR) researches the biology and regeneration of the pancreas, especially the insulin-producing beta cells. The primary aim is to enable regenerative therapy approaches for the treatment of diabetes mellitus and thus to provide alternatives to traditional therapy approaches. The IDR seks to discover novel drugs that enhance beta cell differentiation and function and is working towards a beta cell replacement therapy.

To the IDR website

Institute of Epigenetics and Stem Cells (IES)

Director: Maria Elena Torres-Padilla
Chair ofStem Cell Biology at Ludwig-Maximilians-Universität München

Research within the Institute of Epigenetics and Stem Cells (IES) aims at determining how stem cells originate in vivo and at establishing epigenetic principles behind changes in cellular plasticity and genome reprogramming. They study how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes using a variety of approaches including quantitative imaging, modeling, functional genomics and cell biology. Understanding the molecular mechanisms behind the maintenance and manipulation of cellular plasticity will have strong implications in regenerative medicine and disease, and will help in deciphering human reproduction and infertility.

To the IES website

Institute of Functional Epigenetics (IFE)

Director: Prof. Dr. Robert Schneider

The Institute of Functional Epigenetics (IFE) is interested in how genes are packaged within the nucleus of a cell. The focus is on the so-called "histone proteins" on which the DNA strands are wound and that can determine whether a gene can be read or not. In addition, we are examining the connections between common diseases and distortions in DNA packing.

To the IFE website

Institute of Stem Cell Research (ISF)

Director: Prof. Dr. Magdalena Götz
Chair of Physiological Genomics at Ludwig Maximilians Universität Munich

The Institute of Stem Cell Research (ISF) investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair. The aim of these approaches is the self-renewal of injured or degenerated tissue.

To the ISF website

Institute of Translational Stem Cell Research (ITS)

Director: Prof. Dr. Tor Henrik Semb

The objective of the Institute of Translational Stem Cell Research (ITS) is to develop a stem cell-based replacement therapy in type 1 diabetes. The scientists aim to develop safe approaches for up-scaled production of insulin-producing beta cells from human pluripotent stem cells (hPSCs). An important milestone in the short term is the proper production of the cells following defined standards of Good Manufacturing Practice (GMP). The ITS works closely together with the University of Copenhagen.

To the ITS website

Research Unit Protein Science (PROT)

Head: Dr. Stefanie Hauck

The independent Research Unit Protein Science (PROT) investigates the composition of protein complexes and their integration into cellular processes and protein networks. One research focus is the analysis of the cooperation of genetic variance and environmental factors in the field of neurodegenerative and metabolic diseases. The aim of this research is to identify biological systems and their specific disease-related disorders on a systematic level, thus contributing to a molecular understanding of diseases.

To the PROT website

Research Unit Sensory Biology and Organogenesis (SBO)

Head: Dr. Hernán López-Schier

The independent Research Unit Sensory Biology and Organogenesis (SBO) investigates cellular, molecular and physiological reactions to mechanical stimuli and sensory disorders, using the zebra fish as a model system. The main focus is on the physical and mechanical properties of the tissue. The aim of this research is to investigate the mechanisms controlling the development, self-regulation and regeneration of the sensory system as well as the evolution of the sensory organs for the perception of the environment.

To the SBO website

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