Institutes / Research Units

Genetics & Epidemiology

Institute of Developmental Genetics (IDG)

Director: Prof. Dr. Wolfgang Wurst

Chair of Developmental Genetics at Technische Universität München

The Institute of Developmental Genetics (IDG) focuses on the functional analysis of the mammalian genomes, the development of methods for such analysis and on the development of animal models for the analysis of the genome and the study of the pathogenesis of human diseases. The aim of this research is to investigate genetically determined diseases of the central nervous systems, the eye, and the skeletal system, and to elucidate the molecular mechanisms that control embryonal development.

To the IDG website

Institute of Epidemiology (EPI)

Director: Prof. Dr. Annette Peters

The Institute of Epidemiology (EPI) assesses genetic, environmental and lifestyle risk factors which jointly determine the occurrence of major chronic diseases. The focus is on the development and progression of metabolic, respiratory and allergic diseases, as well as heart diseases and mental health. The goal is to understand the molecular underpinning of disease better and to translate this knowledge into personalized approaches of prevention as well as polices to improve health. Research builds on the unique resources of the KORA cohort, the KORA myocardial infarction registry, and the KORA aerosol measurement station. Aging-related phenotypes have been added to the KORA research portfolio within the frame of the Research Consortium KORA-Age. Moreover, the institute makes use of the birth cohorts GINI and LISA. It plays a leading role in the planning and setting up of the German National Cohort and builds the NAKO biorepository. 

The the EPI website

- Research Unit Molecular Epidemiology (AME)

Head: Dr. Christian Gieger


The Research Unit Molecular Epidemiology (AME) in the Institute of Epidemiology analyses population-based chohorts and case studies for certain diseases, using genomics, epigenomics, transcriptomics, proteomics, metabolomics and functional analyses. The aim of this research is to decipher the molecular mechanisms of complex diseases like type 2 diabetes or obesity. The unit administers the biological specimen repository of the Department of Epidemiology and stores the samples for national and international projects.

To the AME website

Independent Research Group Clinical Epidemiology (KEPI)

Head: Prof Dr. Jakob Linseisen

The Independent Research Group Clinical Epidemiology (KEPI) will establish a patient-oriented research programme in close clinical cooperation. The scientific interests refer to early detection and secondary prevention of chronic diseases (like metabolic diseases, cardiovascular and respiratory diseases) and their complications. Furthermore the group will focus on health care research based on patient cohorts and epidemiologic registries.

To the KEPI website

Institute of Experimental Genetics (IEG)

Director: Prof. Dr. Martin Hrabě de Angelis


The research objective of the Institute of Experimental Genetics (IEG) is to elucidate the causes and pathogenesis of human diseases. Due to its prominent role in interdisciplinary and international consortia, the IEG is a global leader in the systemic study of mouse models for human diseases and the elucidation of involved genes. The main focus is on metabolic diseases such as diabetes. The IEG is part of the Helmholtz Diabetes Center (HDC).
 
to the IEG website
to the GAC website
to the HDC website

- Genome Analysis Center (GAC)

Head: Prof. Dr. Jerzy Adamski

The Research Unit Genome Analysis Center (GAC), headed by Prof. Dr. Jerzy Adamski is part of the IEG. GAC is a core research facility with major focus to investigate complex processes in the development and progression of common complex diseases in man, and the challenge of environment to human health. GAC Metabolomics (www.gac-munich.de) has state of the art know-how and expertise with human cohort, animal samples and cell lines analyses and data interpretation.

to the GAC website
to the IEG website

Institute of Genetic Epidemiology (IGE)

Director: Prof. Dr. Konstantin Strauch

Chair of Genetic Epidemiology at Ludwig Maximilians Universität Munich

The Institute of Genetic Epidemiology (IGE) deals with genetic statistics. This comprises planning, realization and analysis of genetic-epidemiological projects of complex diseases as well as on the development and implementation of new statistical methods. The focus of the institute’s work is on diseases that are assessed in the context of the population-based KORA cohort. The aim of the institute is to contribute to the elucidation of genetic causes of complex diseases.

To the IGE website

Institute of Health Economics and Health Care Management (IGM)

Director: Prof. Dr. Reiner Leidl

Chair of Health Economics and Health Care Management at Ludwig Maximilians Universität Munich

The Institute of Health Economics and Health Care Management (IGM) analyzes approaches to improve the effectiveness and efficiency of health care. Using empirical methods, economic, socioeconomic and management issues are investigated at the level of health systems, of medical technologies and of care strategies.

To the IGM website

Institute of Human Genetics (IHG)

Director: Prof. Dr. Thomas Meitinger

Chair of Human Genetics at Technische Universität München

The identification and functional characterization of genes related to disease are at the heart of research carried out at the Institute of Human Genetics (IHG). Mapping techniques are applied in search of disease associated gene variants. Research groups focus on cardiovascular disorders, neurological disorders and energy metabolism disorders. The aim of this research is to achieve a better understanding of the genetic basis of multifactorial diseases.

To the IHG website

Institute of Neurogenomics (ING)

Director: Prof. Dr. Juliane Winkelmann

Chair of Neurogenomics at Technische Universität München

At the Institute of Neurogenomics (ING), the focus is on the genetic basis of neurological diseases. The research concentrates on the underlying genomic architecture and the molecular mechanisms of complex genetic as well as rare neurological diseases. The objective is to investigate the genetic basis of neurological diseases in order to improve diagnosis and ultimately make it possible to offer patients tailored, personalized treatment.

To the ING website

Research Unit Comparative Medicine (AVM)

Head: PD Dr. Markus Brielmeier


The independent Research Unit Comparative Medicine (AVM) is a central service platform and as such ensures state-of-the-art breeding and husbandry of laboratory animals according to scientific and legal standards.  The unit’s scientific work focuses on hygiene and microbiology of laboratory animals, animal welfare and reproduction biology as well as animal models for human diseases. The unit trains specialist veterinarians and scientists as well as laboratory technicians and animal keepers, focusing on research and translation into therapeutic approaches.

To the AVM website

Diabetes Center

Institute of Diabetes and Cancer (IDC)

Director: Prof. Dr. Stephan Herzig

Chair of Molecular Metabolic Control at Technische Universität München

The Institute of Diabetes and Cancer (IDC) is a member of the Helmholtz Diabetes Center (HDC) at the Helmholtz Center Munich and also a partner within the Joint Heidelberg-IDC Translational Diabetes Program. The Institute of Diabetes and Cancer is tightly integrated into the German Center for Diabetes Research (DZD) and the Collaborative Research Center SFB 1118 “Reactive metabolites and diabetic complications” at the University Medicine Heidelberg, Germany.

The IDC is investigating the molecular basis of severe metabolic disorders, including the Metabolic Syndrome and Type 2 Diabetes, and their roles in tumor initiation and progression.

To the IDC website

Institute of Diabetes Research (IDF)

Director: Prof. Dr. Anette-Gabriele Ziegler

Chair of Diabetes and Gestational Diabetes at Technische Universität München

The Institute of Diabetes Research (IDF) researches the pathogenesis and prevention of type 1 diabetes and gestational diabetes. To this end, it investigates the molecular mechanisms leading to the development of the disease, in particular the interaction of environment, genes and immune system. The aim of this research is to identify markers for early diagnosis and to develop treatments for the prevention and cure of diabetes. IDF is a part of the Helmholtz Diabetes Center (HDC).

To the IDF website
To the HDC website

Institute of Diabetes Research and Metabolic Diseases (IDM)

Director: Prof. Dr. Dr. h.c. Hans-Ulrich Häring

Medical director of Medical Clinic IV at the University Hospital Tübingen

The primary research objective of the Institute of Diabetes Research and Metabolic Diseases (IDM) of Helmholtz Zentrum München at the University of Tübingen is the individualized prediction of diabetes risk, diabetes prevention and the personalized treatment of diabetes. The main research focus is on gene-environment interaction in type 2 diabetes. IDM is a part of the Helmholtz Diabetes Center (HDC).

To the website of IDM
To the HDC website

Institute of Diabetes and Obesity (IDO)

Director: Prof. Dr. Matthias Tschöp

Chair of Metabolic Diseases at Technische Universität München

The Institute of Diabetes and Obesity (IDO) studies the metabolic syndrome by means of systems biological and translational approaches, using cell-based systems, genetically modified mouse models and clinical intervention studies. The aim of this research is to discover new signaling pathways in order to develop innovative interdisciplinary approaches for the personalized prevention and treatment of obesity, diabetes and concomitant diseases. IDO is a part of the Helmholtz Diabetes Center (HDC).

To the IDO website
To the HDC website

- Research Unit NeuroBiology of Diabetes (NBD)

Head: Dr. Paul Pfluger

The Research Unit NeuroBiology of Diabetes is associated with the IDO, and aims to unravel the role of the central nervous system in the etiology of metabolic disease. Focus is directed towards understanding the impact of hypothalamic inflammation for the development of obesity and diabetes type 2. The NBD further assesses the role of epigenetic signaling as gene-environment interface for our adaptive metabolic control. Last, the NBD aims to gain insight into the underpinnings of leptin resistance, yoyo dieting, and our failure to stay lean.

To the NBD website

Institute of Diabetes- and Regeneration Research (IDR)

Director: Prof. Dr. Heiko Lickert

Chair of Diabetes Research / Beta Cell Biology at Technische Universität München

The Institute of Diabetes and Regeneration Research (IDR) researches the biology and regeneration of the pancreas, especially the insulin-producing beta cells. The primary aim is to enable regenerative therapy approaches for the treatment of diabetes mellitus and thus to provide alternatives to traditional therapy approaches. The IDR seks to discover novel drugs that enhance beta cell differentiation and function and is working towards a beta cell replacement therapy. IDR is a part of the Helmholtz Diabetes Center (HDC).

To the IDR website
To the HDC website

Institute of Functional Epigenetics (IFE)

Director: Prof. Dr. Robert Schneider

The Institute of Functional Epigenetics (IFE) is interested in how genes are packaged within the nucleus of a cell. The focus is on the so-called "histone proteins" on which the DNA strands are wound and that can determine whether a gene can be read or not. In addition, we are examining the connections between common diseases and distortions in DNA packing.

To the IFE website

- Research Unit Molecular Epigenetics (MEG)

Head: Prof. Dr. Dirk Eick


The Research Unit Molecular Epigenetics (MEG) researches basic epigenetic mechanisms of gene regulation, thus creating the basis for a better understanding of the role of epigenetics in the etiology of diseases. 

To the MEG website

Institute of Pancreatic Islet Research, Paul-Langerhans-Institut Dresden (IPI)

Director: Prof. Dr. Michele Solimena

Chair of Molecular Diabetology at Technische Universität Dresden

The Institute of Pancreatic Islet Research (IPI) focuses on basic and clinical research on pancreatic beta cells, which are responsible for production and secretion of insulin.

To the IPI website

Health & Environment

Research Unit Gene Vectors (AGV)

Head: Prof. Dr. Wolfgang Hammerschmidt


The independent Research Unit Gene Vectors (AGV) investigates the Epstein Barr Virus (EBV) and its interaction with human B-cells, in particular in the infection and transformation of the target cells to tumor cells or cells, which proliferate indefinitely. The aim of this research is to achieve a detailed understanding of the EBV infection in the development of tumors and to put these insights to medical use in the shape of a unique model system.

To the AGV website

Research Unit Apoptosis in Hematopoetic Stem Cells (AHS)

Head: Prof. Dr. Irmela Jeremias

Mildred Scheel Research Professorship at Ludwig-Maximilians-Universität München

The vision of the Research Unit Apoptosis in Hematopoietic Stem Cells (AHS) is to develop novel anti-cancer treatment strategies that eliminate leukemia stem cells. We aim at discovering mechanisms that allow inducing apoptosis in tumor stem cells, in order to overcome treatment resistance and prevent disease relapse. Using genetically modified patients´ leukemia cells growing in mice, we search for cellular structures which represent effective novel targets for therapy.

to the AHS website

Research Unit Molecular Immunoregulation (AMIR)

Head: Dr. Vigo Heissmeyer


The Reserarch Unit Molecular Immunoregulation (AMIR), headed up by Dr. Vigo Heissmeyer, is part of the Institute of Molecular Immunology. AMIR investigates the molecular programming of T-cell tolerance, inter alia at the level of posttranscriptional gene regulation. The aim of AMIR is to achieve a better understanding of the molecular programs of T-cells, which make a distinction between the body’s own structure and foreign structures possible. The research focus is on autoimmune diseases such as type 1 diabetes and Lupus erythematodes.

To the AMIR website

Comprehensive Molecular Analytics (CMA)

Head: Prof. Dr. Ralf Zimmermann

Chair of Analytical Chemistryat Rostock University

The Helmholtz Zentrum München and the University of Rostock (Chair for Analytical Chemistry) jointly conduct research in the independent Comprehensive Molecular Analytics (CMA) Cooperation Group. The research focuses on the development and application of mass spectrometry-based analysis techniques in order to characterize complex molecular substance mixtures. New measurement technologies are developed and molecular profiles are created in the Joint Mass Spectrometry Centre (JMSC), particularly with a view to the analysis of aerosols and their effects on health.

 Zur CMA-Website 

Institute of Epidemiology (EPI)

Director: Prof. Dr. Annette Peters

The Institute of Epidemiology (EPI) assesses genetic, environmental and lifestyle risk factors which jointly determine the occurrence of major chronic diseases. The focus is on the development and progression of metabolic, respiratory and allergic diseases, as well as heart diseases and mental health. The goal is to understand the molecular underpinning of disease better and to translate this knowledge into personalized approaches of prevention as well as polices to improve health. Research builds on the unique resources of the KORA cohort, the KORA myocardial infarction registry, and the KORA aerosol measurement station. Aging-related phenotypes have been added to the KORA research portfolio within the frame of the Research Consortium KORA-Age. Moreover, the institute makes use of the birth cohorts GINI and LISA. It plays a leading role in the planning and setting up of the German National Cohort and builds the NAKO biorepository. 

The the EPI website

- Research Unit Molecular Epidemiology (AME)

Head: Dr. Christian Gieger


The Research Unit Molecular Epidemiology (AME) in the Institute of Epidemiology analyses population-based chohorts and case studies for certain diseases, using genomics, epigenomics, transcriptomics, proteomics, metabolomics and functional analyses. The aim of this research is to decipher the molecular mechanisms of complex diseases like type 2 diabetes or obesity. The unit administers the biological specimen repository of the Department of Epidemiology and stores the samples for national and international projects.

To the AME website

Institute of Allergy Research (IAF)

Director: Prof. Dr. Carsten Schmidt-Weber

Chair of Molecular Allergology and Environmental Research at Technische Universität München

The Institute of Allergy Research (IAF) researches mechanisms responsible for the development of allergies and the build-up of allergy tolerance in the context of genetic predisposition, immune system and environmental factors. In cooperation with the Center of Allergy & Environment, the institute conducts basic and basic clinical research. The aim is to understand the diseases, assess risks, intervene preventatively and to treat these diseases successfully.

To the IAF website

Institute of Asthma and Allergy Prevention (IAP)

Director: Prof. Dr. Erika von Mutius

The focus of work in the Institute of Asthma and Allergy Prevention (IAP) will be in depth characterization of asthma phenotypes through the ALLIANCE cohort of the German Centre for Lung Research (DZL). Another aim is identifying the relevant asthma and allergy protective microbial factors (HERA and other studies). The long term mission of the Institute is to foster the prevention of asthma and allergies.

To the IAP website

Institute of Environmental Medicine (IEM)

Director: Prof. Dr. Claudia Traidl-Hoffmann

Chair of Environmental Chemsitry at Technische Universität München

The Institute of Environmental Medicine (IEM) devotes its work to the basic and translational research in environment-human-interaction with a main emphasis on allergic diseases. This research is carried out within six special fields: Aerobiology, Experimental Allergy Models, Microbiome, Prevention and Therapy, Environmental Immunology and Medical Environmental Bioinformatics. The principal objective hereby is to prevent chronic environmental diseases and to ensure a sustainable patient treatment.

To the IEM website

Institute of Lung Biology and Diseases/ Comprehensive Pneumology Center (CPC)

Director: Dr. Antje Brand (acting, admin.)


Chronic lung diseases are the research focus of the Institute of Lung Biology and Diseases (iLBD) and of the Comprehensive Pneumology Center (CPC). The aim of this research are novel approaches to diagnostics or therapy. To this end, scientists strive to elucidate the underlying mechanisms of diseases such as chronic obstructive pulmonary disease (COPD), lung fibrosis, lung cancer or asthma and complications following lung transplantation (bronchiolitis obliterans) and translate them into therapeutic approaches for patients.

To the CPC / iLBD website

Research Unit Lung Repair and Regeneration (LRR)

Head: Dr. Dr. Melanie Königshoff

The Lung Repair and Regeneration Research Unit (LRR) is part of the Comprehensive Pneumology Center (CPC), which is a joint undertaking of the Helmholtz Zentrum München, Ludwig Maximilian University Munich with its University Hospital, and the Asklepios Specialist Clinics Munich-Gauting. The CPC's objective is to conduct research on chronic lung diseases in order to develop new diagnostic tools and therapies. The LRR Research Unit examines new mechanisms and repair processes in the lungs for a better understanding that will allow the development of new therapeutic approaches. The unit also focuses on developing new methods in order to reduce the gap between pre-clinical research and its application on patients. The CPC is a facility of the German Center for Lung Research (Deutsches Zentrum für Lungenforschung - DZL).

To the LRR website

Institute of innovative Radiotherapy (IRT)

Director: Prof. Dr. Stephanie Combs

Chairof Radiation Oncology at Technische Universität München

The Institute of Innovative Radiotherapy (iRT) is a part of the Department of Radiation Sciences (DRS) of the Helmholtz Zentrum München (HMGU). The Institute of iRT has a strong link to the Department of Radiation Oncology at the Klinikum rechts der Isar, Technische Universität München (TUM). The main focus is clinically oriented research related to technical and biological issues of radiation therapy. This involves research in preclinical radio- and molecular biology, imaging, as well as new technical developments in radiation technology, and provides a solid basis to bridge the gap between the basic and pre-clincial programmes of the DRS members.

To the iRT website
To the DRS website

Institute of Radiation Biology (ISB)

Director: Prof. Dr. Michael Atkinson

Chair of Radiation Biology at Technische Universität München

Using molecular and cell biological techniques, the Institute of Radiation Biology (ISB) researches the complex cellular reactions after exposure to radiation.  The focus is on analyzing the effects of low dose radiation exposure and on studies to increase the effectiveness and specificity of tumor radiotherapy. This research is conducted by four interlinked research groups. ISB is a part of the Department of Radiation Sciences (DRS).

To the ISB website
To the DRS website

Institute of Radiation Protection (ISS)

Director (acting): Prof. Dr. Werner Rühm


The Institute of Radiation Protection (ISS) focuses on the measurement and evaluation of occupational, medical and environmental radiation exposure, analyses related risks of cancer and cardiovascular diseases and organizes training courses in radiation protection. The institute’s aim is to achieve a better understanding of the effects of radiation, using innovative procedures, and to optimize the safe use of radiation in industry and medicine. ISS is a part of the Department of Radiation Sciences (DRS).

To the ISS website
To the Education and Training website (German only)
To the DRS website

WG Tissue Control of Immunocytes (TCI)

Head: Prof. Dr. Elfriede Nößner

The Working Group Tissue control of Immunocytes (TCI) is analyzing all types of immune cells (T cells, natural killer cells, dendritic cells, macrophages or monocytes) in various tissue milieus, i.e. blood, kidney, liver, lung, in healthy and pathological conditions (chronic inflammation, fibrosis or malignancy, etc.). It is the aim to determine how the features of these cells are modulated through the local milieu and how the cells communicate with each other. The knowledge gained will be used to design immunotherapeutic strategies to enable those activities required to efficiently mobilize the immune system to fight disease and restore or maintain health. 

The working group is part of Immunoanalytics (IMA) that also operates a Core Facility. Research results and know-how are directly translated into state of the art services for internal and external users.

To the TCI website

WG Translational Molecular Immunology (TMI)

Head: Prof. Dr. Ralph Mocikat

 

The independent research unit Translational Molecular Immunology (TMI) investigates the basic mechanisms of the immune system and forms an interface between knowledge-oriented research and clinical application. The aim is to establish and to refine personalized therapeutic approaches, which are based on modulating the immune response.

To the TMI website

Institute of Virology (VIRO)

Director: Prof. Dr. Ulrike Protzer

Chair of Virology at Technische Universität München

The Institute of Virology (VIRO) investigates viruses that can cause chronic infections life-threatening diseases in humans. The research focus is on the AIDS virus (HIV), on endogenous retroviruses that are integrated into our germline, and on hepatitis B and C viruses, which cause liver cirrhosis and hepatocellular carcinoma.  Molecular studies identify new diagnostic and therapeutic concepts to prevent and treat these viral diseases or to prevent the development of virus-induced tumors.

to the VIRO website

Research Unit Radiation Cytogenetics (ZYTO)

Head: Prof. Dr. Horst Zitzelsberger


The independent Research Unit Radiation Cytogenetics (ZYTO) investigates radiation induced chromosome and DNA damage in cell systems and human tumors. The focus is on the elucidation of mechanisms associated with radiation-induced carcinogenesis and radiation sensitivity of tumor cells. The aim of this research is to find biomarkers associated with radiation-induced tumors to develop personalized radiation therapy for the stratification of patients. ZYTO is a part of the Department of Radiation Sciences (DRS).

To the ZYTO website
To the DRS website

Stem Cells

Institute of Epigenetics and Stem Cells (IES)

Director: Maria Elena Torres-Padilla

Chair ofStem Cell Biology at Ludwig-Maximilians-Universität München

Research within the Institute of Epigenetics and Stem Cells (IES) aims at determining how stem cells originate in vivo and at establishing epigenetic principles behind changes in cellular plasticity and genome reprogramming. They study how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes using a variety of approaches including quantitative imaging, modeling, functional genomics and cell biology. Understanding the molecular mechanisms behind the maintenance and manipulation of cellular plasticity will have strong implications in regenerative medicine and disease, and will help in deciphering human reproduction and infertility.

To the IES website

Institute of Stem Cell Research (ISF)

Director: Prof. Dr. Magdalena Götz

Chair of Physiological Genomics at Ludwig Maximilians Universität Munich

The Institute of Stem Cell Research (ISF) investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair. The aim of these approaches is the self-renewal of injured or degenerated tissue.

To the ISF website

Research Unit Sensory Biology and Organogenesis (SBO)

Head: Dr. Hernán López-Schier


The independent Research Unit Sensory Biology and Organogenesis (SBO) investigates cellular, molecular and physiological reactions to mechanical stimuli and sensory disorders, using the zebra fish as a model system. The main focus is on the physical and mechanical properties of the tissue. The aim of this research is to investigate the mechanisms controlling the development, self-regulation and regeneration of the sensory system as well as the evolution of the sensory organs for the perception of the environment.

To the SBO website

Enabling Technologies

Research Unit Analytical Pathology (AAP)

Head: Prof. Dr. Axel Walch


The independent Research  Unit Analytical Pathology Department (AAP) carries out scientific development, as a complement to research units with a clinical and fundamental orientation, of translational research on diseases that occur in tissue. AAP is involved in the translation of (for example) in-vitro models or animal models to application in humans. AAP thus links basic research with diagnostic application, subsequently translating the findings of experimental and molecular pathology into procedures for the classification of diseases and predictive diagnostics dealing with tissue.

To the AAP website

Institute of Bioinformatics and Systems Biology (IBIS)

Director: Dr. Gabriele Kastenmüller (acting)


The Institute of Bioinformatics and Systems Biology (IBIS) analyses and interprets biological data in order to capture information on the etiology and progression of human diseases in rational models. The institute’s workgroups focus on qualitative and quantitative modeling, on the interconnection of metabolic profiles with genetic variance, on the systematic interpretation of high throughput data and on the systems biology of small molecules.

To the IBIS website

Institute of Biological and Medical Imaging (IBMI)

Director: Prof. Dr. Vasilis Ntziachristos

Chair of Biological Imaging at Technische Universität München

The Institute of Biological and Medical Imaging (IBMI) researches in vivo imaging technologies for biosciences. It develops systems, theories and methods for imaging and image reconstruction as well as animal models for the interrogation of new technologies at the biological, pre-clinical and clinical level. The aim of this research is to provide innovative tools for the biomedical laboratory, for diagnostics and disease monitoring and for the treatment of human diseases.

To the IBMI website

Institute of Computational Biology (ICB)

Director: Prof. Dr. Dr. Fabian Theis

Chair of Mathematical Modeling of Biological Systems at Technische Universität München

The Institute of Computational Biology (ICB) develops and applies methods for the model-based description of biological systems, using a data-driven approach by integrating information on multiple scales ranging from single-cell time series to large-scale omics. Given the fast technological advances in molecular biology, their aim is to provide and collaboratively apply innovative tools with experimental groups in order to jointly advance our understanding and treatment of common human diseases.


To the ICB website
To the ASC website

- Research Unit Scientific Computing (ASC)

Head: PD Dr. Wolfgang zu Castell


The Research Unit Scientific Computing (ASC) is a part of the Institute of Computational Biology and as such combines the organization of the central data center of Helmholtz Zentrum München with research componentes in scientific computing. The aim of the research unit is the provision of ICT serves for all institutes and research units of Helmholtz Zentrum München and to develop and apply mathematical methods for computational analysis and simulation of biological system.

To the ASC website
To the ICB website

Institute of Medicinal Chemistry (IMC)

Director: Prof. Dr. Oliver Plettenburg

Institute of Organic Chemistry at Leibniz Universität Hannover

The Institute for Medicinal Chemistry (IMC) undertakes research into the chemical properties of new and old active substances, as well as the development of innovative therapeutic methods. The institute, based in Hanover, is an external facility of the Helmholtz Zentrum München and is operated in co-operation with the Leibniz University Hanover.

To the IMC website

Research Unit Protein Science (PROT)

Head: Dr. Stefanie Hauck


The independent Research Unit Protein Science (PROT) investigates the composition of protein complexes and their integration into cellular processes and protein networks. One research focus is the analysis of the cooperation of genetic variance and environmental factors in the field of neurodegenerative and metabolic diseases. The aim of this research is to identify biological systems and their specific disease-related disorders on a systematic level, thus contributing to a molecular understanding of diseases.

To the PROT website

Institute of Molecular Toxicology and Pharmacology (TOXI)

Director: Prof. Dr. Martin Göttlicher

Chair of Toxicology and Environmental Hygiene at Technische Universität München

The Institute of Molecular Toxicology and Pharmacology (TOXI) investigates the cellular response pathways and genetic foundations with which the organism reacts to chemical substances.. The aim of this research is to achieve a better understanding of  the role of these mechanisms in the etiology and progression of complex diseases and to reduce health risks. This leads to the development of approaches for the prevention of environmentally related diseases and for innovative therapeutic concepts. TOXI includes the Research Unit Cellular Signal Integration (AZS).

To the TOXI website
To the AZS website

Research Unit Cellular Signal Integration (AZS)

Head: Dr. Daniel Krappmann


The Research Unit Cellular Signal Integration (AZS) at the Institute of Molecular Toxicology and Pharmacology (TOXI)  conducts research for a better understanding of cellular response pathways. In doing so, it focuses on the interaction of proteins complexes and the effects of posttranslational modifications. The aim of this research is to understand the faulty regulation of the signal complexes in the immune system in case of infectious diseases and the development of lymphoma, and to attack this pharmacologically.

To the AZS website
To the TOXI website

Institute of Structural Biology (STB)

Director: Prof. Dr. Michael Sattler

Chair of Biomolecular NMR Spectroscopy at Technische Universität München

The Institute of Structural Biology (STB) investigates the spatial structures of biological macromolecules, analyses the interplay between the structure and dynamics and develops NMR spectroscopy techniques for a structural analyses of complex biomolecular systems.  The aim of this research is to elucidate the biological function of molecules and their involvement in diseases and to apply structural data as a basis for the design and development of small molecule inhibitors in combination with chemical biology approaches.

To the STB website

Environmental Science

Research Unit BioGeoChemistry and Analytics (BGC)

Head: PD Dr. Philippe Schmitt-Kopplin


The independent Research Unit Analytical BioGeoChemistry (BGC) investigates molecular interactions of substances in biogeo systems. High-resolution methods in the elucidation of organic structures, in conjunction with separation sciences and mathematical methods, allow for a precise space and time-resolved analysis. The aim of this research is to achieve a better understanding of the molecular processes in ecosystems and to improve the identification of biomarkers in organisms.  BGC is a part of the Department of Environmental Sciences (DES).

To the BGC website
To the DES website

Institute of Biochemical Plant Pathology (BIOP)

Director: Prof. Dr. Jörg Durner

Chair of Biochemical Plant Pathology at Technische Universität München

The Institute of Biochemical Plant Pathology (BIOP) explores defense mechanisms, growth and fitness of plants in response to environmental cues, with a focus on molecular mechanisms that allow plants to respond to biotic and abiotic factors. The aim of this research is to find new procedures for sustainable agriculture and biotechnological use of plants, as well as to contribute to safeguarding the role of plants in the nourishment and health of human beings.
BIOP is a part of the Department of Environmental Sciences (DES). BIOP includes the Research Unit Environmental Engineering (EUS).

To the BIOP website
To the EUS website
To the DES website

- Research Unit Environmental Simulation (EUS)

Head: Prof. Dr. Jörg-Peter Schnitzler


The Research Unit Environmental Simulation (EUS) is a part of the Institute of Biochemical Plant Pathology. It pools infrastructure and expertise for researching the influence of the global climate change on growth, yield and health of crops and energy plants, as well as on biodiversity.  EUS offer environmental simulation at the highest level and state-of-the-art methods of eco physiology and mass spectroscopy. Its research focuses on the biosphere-atmosphere exchange of biogenic volatile organic compounds.

To the EUS website
To the BIOP website

Research Unit Comparative Microbiome Analysis (COMI)

Head: Prof. Dr. Michael Schloter


The independent Research Unit Comparative Microbiome Analysis (COMI) investigates the structure and function of microbial communities in the soil and identifies abiotic and biotic parameters, which control abundance, diversity and activity of the corresponding microbiomes. The aim of this research is to make the genetic resources of the soil microflora better usable for a sustainable bio economy. EGEN is a part of the Department of Environmental Sciences (DES).

To the COMI website
To the DES website

Institute of Groundwater Ecology (IGOE)

Director: Dr. Christian Griebler (acting)


The Institute of Groundwater Ecology (IGOE) focuses on the processes of self-cleaning and the transport of harmful substances in groundwater and develops ecological assessment criteria for groundwater ecosystems. The principal aim is to research the microbial processes that lead to self-cleaning of groundwater and thus contribute to preserving our most important source of drinking water. IGOE is a part of the Department of Environmental Sciences (DES).

To the IGOE website
To the DES website

- Research Unit Environmental Organic Isotope Chemistry (EOIC)

Head: Dr. Martin Elsner

The Research Unit Environmental Organic Isotope Chemistry (EOIC) investigates the degradation of chemicals in the environment. The analysis of stable isotopes is used to assess the behavior of organic substances in complex systems and to characterize metabolic fluxes in humans. 

To the EOIC Website
To the DES Website

Institute of Network Biology (INET)

Head: Prof. Dr. Pascal Falter-Braun

Professor of Microbe-Host-Interactions at Ludwig-Maximilians-Universität München

Research at the Institute of Network Biology (INET) aims to understand the organizational and functional principles of protein interaction networks. Of particular interest is to understand how these networks change in response to environmental influences, microbial and endogenous substances, and due to evolutionary processes to positively influence the organism. Such an understanding is envisioned to enable the modulation of complex networks for medical and bio-economical applications. The institute pursues an interdisciplinary research agenda based on experimental and theoretical systems biology approaches.

To the INET website
To the DES website

Research Unit Plant Genome and Systems Biology (PGSB)

Head: Dr. Klaus Mayer

The main focus of the independent Research Unit Plant Genome and Systems Biology (PGSB) is plant genome and systems-oriented bioinformatics. It has a focus towards analyzing genomic encryption, expression patterns, functional and systems biology of plants. PGSB also maintains a large data set of plant genomes in databases, which it makes available to the public along with comparative analyses.

To the PGSB website
To the DES website