Molecular Targets & Therapies



Research Unit Molecular Immunoregulation (AMIR)

Head: Dr. Vigo Heissmeyer

The Reserarch Unit Molecular Immunoregulation (AMIR), headed up by Dr. Vigo Heissmeyer, is part of the Institute of Molecular Immunology. AMIR investigates the molecular programming of T-cell tolerance, inter alia at the level of posttranscriptional gene regulation. The aim of AMIR is to achieve a better understanding of the molecular programs of T-cells, which make a distinction between the body’s own structure and foreign structures possible. The research focus is on autoimmune diseases such as type 1 diabetes and Lupus erythematodes.

To the AMIR website

Institute of Functional Epigenetics (IFE)

Director: Prof. Dr. Robert Schneider

The Institute of Functional Epigenetics (IFE) is interested in how genes are packaged within the nucleus of a cell. The focus is on the so-called "histone proteins" on which the DNA strands are wound and that can determine whether a gene can be read or not. In addition, we are examining the connections between common diseases and distortions in DNA packing.

To the IFE website

Institute of Medicinal Chemistry (IMC)

Director: Prof. Dr. Oliver Plettenburg
Institute of Organic Chemistry at Leibniz Universität Hannover

The Institute for Medicinal Chemistry (IMC) undertakes research into the chemical properties of new and old active substances, as well as the development of innovative therapeutic methods. The institute, based in Hanover, is an external facility of the Helmholtz Zentrum München and is operated in co-operation with the Leibniz University Hanover.

To the IMC website

Institute of Network Biology (INET)

Head: Prof. Dr. Pascal Falter-Braun
Professor of Microbe-Host-Interactions at Ludwig-Maximilians-Universität München

Research at the Institute of Network Biology (INET) aims to understand the organizational and functional principles of protein interaction networks. Of particular interest is to understand how these networks change in response to environmental influences, microbial and endogenous substances, and due to evolutionary processes to positively influence the organism. Such an understanding is envisioned to enable the modulation of complex networks for medical and bio-economical applications. The institute pursues an interdisciplinary research agenda based on experimental and theoretical systems biology approaches.

To the INET website

Institute of Radiation Medicine (IRM)

Director: Prof. Dr. Stephanie Combs
Chair of Radiation Oncology at Technische Universität München

The Institute of Radiation Medicine (IRM) is a part of the Department of Radiation Sciences (DRS) of the Helmholtz Zentrum München (HMGU). The Institute has a strong link to the Department of Radiation Oncology at the Klinikum rechts der Isar, Technische Universität München (TUM). The main focus is clinically oriented research related to technical and biological issues of radiation therapy. This involves research in preclinical radio- and molecular biology, imaging, as well as new technical developments in radiation technology, and provides a solid basis to bridge the gap between the basic and pre-clincial programmes of the DRS members.

To the IRM website

Institute of Metabolism and Cell Death (MCD)

Director: Dr. Marcus Conrad

To the MCD website

Institute of Structural Biology (STB)

Director: Prof. Dr. Michael Sattler
Chair of Biomolecular NMR Spectroscopy at Technische Universität München

The Institute of Structural Biology (STB) investigates the spatial structures of biological macromolecules, analyses the interplay between the structure and dynamics and develops NMR spectroscopy techniques for a structural analyses of complex biomolecular systems.  The aim of this research is to elucidate the biological function of molecules and their involvement in diseases and to apply structural data as a basis for the design and development of small molecule inhibitors in combination with chemical biology approaches.

To the STB website

Institute of Molecular Toxicology and Pharmacology (TOXI)

Director: Prof. Dr. Martin Göttlicher
Chair of Toxicology and Environmental Hygiene at Technische Universität München

The Institute of Molecular Toxicology and Pharmacology (TOXI) investigates the cellular response pathways and genetic foundations with which the organism reacts to chemical substances.. The aim of this research is to achieve a better understanding of  the role of these mechanisms in the etiology and progression of complex diseases and to reduce health risks. This leads to the development of approaches for the prevention of environmentally related diseases and for innovative therapeutic concepts. TOXI includes the Research Unit Cellular Signal Integration (AZS).

To the TOXI website

Research Unit Cellular Signal Integration (AZS)

Head: Dr. Daniel Krappmann

The Research Unit Cellular Signal Integration (AZS) at the Institute of Molecular Toxicology and Pharmacology (TOXI)  conducts research for a better understanding of cellular response pathways. In doing so, it focuses on the interaction of proteins complexes and the effects of posttranslational modifications. The aim of this research is to understand the faulty regulation of the signal complexes in the immune system in cas

To the AZS website

Institute of Virology (VIRO)

Director: Prof. Dr. Ulrike Protzer

Chair of Virology at Technische Universität München

The Institute of Virology (VIRO) investigates viruses that can cause chronic infections life-threatening diseases in humans. The research focus is on the AIDS virus (HIV), on endogenous retroviruses that are integrated into our germline, and on hepatitis B and C viruses, which cause liver cirrhosis and hepatocellular carcinoma.  Molecular studies identify new diagnostic and therapeutic concepts to prevent and treat these viral diseases or to prevent the development of virus-induced tumors.

to the VIRO website

Research Unit Radiation Cytogenetics (ZYTO)

Head: Prof. Dr. Horst Zitzelsberger

The independent Research Unit Radiation Cytogenetics (ZYTO) investigates radiation induced chromosome and DNA damage in cell systems and human tumors. The focus is on the elucidation of mechanisms associated with radiation-induced carcinogenesis and radiation sensitivity of tumor cells. The aim of this research is to find biomarkers associated with radiation-induced tumors to develop personalized radiation therapy for the stratification of patients. ZYTO is a part of the Department of Radiation Sciences (DRS).

To the ZYTO website
To the DRS website