signaling in mice lung tissue disrupted the formation of the immune cell follicles, prevented lung epithelial cell death and, surprisingly, at the same time triggered lung tissue regeneration. “The lung in those mice regenerated despite the continuous exposure to chronic cigarette smoke. We observed…
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Drug development for lung diseases is complicated. Most clinical trials that test novel drugs fail due to the fact that laboratory models cannot accurately replicate human physiology. Currently specific molecular pathways are often modeled in highly artificial conditions using one or two different…
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nal Biology and the Institute of Lung Health & Immunity at Helmholtz Munich adds: “A comprehensive organ atlas requires many datasets to capture the diversity between both cells and individuals, but combining different datasets is a huge challenge. We developed a benchmarking pipeline to find the…
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Lung fibrosis, or “lung scar” is a chronic disease characterized by excessive fibroblast proliferation, abnormal extracellular matrix deposition, stiffening of alveolar lung tissue, and ultimately loss of lung function. The lack of curative therapies for lung fibrosis not only leads to a high…
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Lung fibrosis, or “lung scar” is a chronic disease characterized by excessive fibroblast proliferation, abnormal extracellular matrix deposition, stiffening of alveolar lung tissue, and ultimately loss of lung function. The lack of curative therapies for lung fibrosis not only leads to a high…
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Our lungs are a marvel, but they have a "weak spot", so to speak, because we can't stop breathing! If the air we breathe in is contaminated with pollutants, these fine substances inevitably end up deep in our lungs. Epidemiology now knows that dust particles or nitrogen oxides trigger inflammation…
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fundamental scientific programs that provide novel therapeutic approaches for chronic lung diseases and explore key environmental triggers. Key research areas include COPD, interstitial lung diseases, lung cancer and lung transplantation. Yildirim places particular emphasis on COPD, which has become…
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fundamental scientific programs that provide novel therapeutic approaches for chronic lung diseases and explore key environmental triggers. Key research areas include COPD, interstitial lung diseases, lung cancer and lung transplantation. Yildirim places particular emphasis on COPD, which has become…
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Inhaled medical substances for the treatment of lung diseases are intended for accumulation in the lung. However, a certain fraction of the drug may also reach secondary organs via the blood, which may result in inadvertent side effects. By using a patented mini-lung-model, Helmholtz Munich…
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that enables the detailed evaluation of fetal organs and tissue, demonstrating a reduction in lung volume in fetuses from SARS-CoV-2 pregnancies – as compared with fetuses from an uninfected reference cohort. “The fetuses of pregnant women who tested positive for SARS-CoV-2 had an overall lower lung…
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