computational analysis to define immune molecular phenotypes relevant to disease. Additionally, in 2024, we plan to incorporate microbiome analysis through 16S rRNA gene sequencing and metagenomics to complement the genomics profiling of human samples. To validate our findings, we employ ex vivo lun…
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In chronic obstructive pulmonary disease, COPD, complex inflammatory processes, and injury to the lung tissue (emphysema) ultimately cause lung alveolar epithelial cells to die. An increased number of inflammatory macrophages differentiating from blood monocytes is largely responsible for this. Lung…
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area of expertise lies in investigating the function of macrophages in the context of lung injury. Specifically, she is focused on understanding the mechanism behind ECM remodeling driven by macrophages. Her research aims to uncover important insights into the underlying biology of lung injury,…
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than ever before. We employ these models to study the early consequences of oncogenic transformation in the lung, and how cells, in combination with expression of different tumor drivers, reshape their niche and respond to standard of care therapy. These new models will provide a foundation for…
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anti-ferroptotic efficacy, as well as to identify new biomarkers for ferroptosis using these transgenic models,” says Conrad. Dr. Ali Önder Yildirim and Dr. Aicha Jeridi from the Institute of Lung Health and Immunity (LHI) are working on the second subproject “Specific examination of the role of…
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What size is the surface of the human lung? Why does it take so long to get from basic research to a drug that fights incurable lung diseases? These and many other questions were answered at the Pint of Science Event at the “Gans am Wasser” in Munich Westpark. With great enthusiasm, many pictures,…
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development and exacerbation of respiratory, allergic, and cardiovascular diseases. Back On this page Specific Topics Scientists at Aerosol Toxicology Publications Contact About our research The human body's first contact with air pollutants occurs primarily at the lung epithelium, which is a…
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ALIAS-Lung In vitro cell exposure at the air-liquid interface (ALI) has proven to be a versatile tool to characterize the relative toxicity of emission sources such as cigarette smoke, engine emissions or man-made nanoparticles and to decipher the biological mechanisms underlying the adverse effects…
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and Ali Önder Yildirim. The extension means that they will continue to receive funding for personnel as well as material resources for MD and Ph.D. doctoral candidates over the next four and a half years. The overall conceptual goal of the GRK "Targets in Toxicology" is to create a deeper…
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approach. Together, we develop innovative strategies for the treatment and prevention of diseases such as allergies, asthma and chronic lung diseases. At the Environmental Health Center (EHC), we conduct cutting edge interdisciplinary research to decipher the effects of environmental influences on…
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