EAGLE (2008-ongoing):


EAGLE LogoEArly Genetics and Lifecourse Epidemiology 

Purpose objective:
The Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium is a consortium of pregnancy and birth cohorts that aims to collaborate to investigate the genetic basis of phenotypes in antenatal and early life and childhood. EAGLE covers a broad range of pathways and phenotypes.
 
Working groups:

  • Asthma, allergy and atopy
    • Asthma and wheezy phenotypes
    • Eczema
    • Exhaled NO
    • Allergic sensitization
  • Behaviour and cognition
  • Blood pressure
  • Bone health
  • Cardiovascular risk factors
  • Early Growth Genetics (EGG)
    • Antenatal growth
    • Postnatal growth
  • Puberty
  • Febrile seizures
  • Infectious disease
  • Insulin and metabolic syndrome

Study design:
Pregnancy and birth cohorts with genomewide data.

Study population:
Participating Cohorts: 1958 British Birth Cohort, ALSPAC, CHOP, COPSAC, DNBC, Exeter Family Study, Generation R, HBCS, LISAplus Munich, GINIplus Munich, MoBa, NFBC66, NRT, Project Viva, Raine.

Study period:
2008 - ongoing.

Investigators:
Elisabeth Thiering, Marie Standl, and Joachim Heinrich (co-investigator from the Institute of Epidemiology, Helmholtz Zentrum München).

Funding:
No external funding.

Contact:
Marie Standl
Helmholtz Zentrum München
German Research Center for Environmental Health

Institute of Epidemiology
Ingolstädter Landstr. 1
D-85758 Neuherberg
Tel. +49-(0)89-3187-4150
Fax +49-(0)89-3187-3380


Related publications:


Horikoshi M et al. Genome-wide associations for birth weight and correlations with adult disease.
Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28.
PMID: 27680694
Abstract

Marinelli M et al. Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.
Sleep. 2016 Oct 1;39(10):1859-1869.
PMID:27568811
Abstract

Middeldorp CM et al. A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.
J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):896-905.e6. doi: 10.1016/j.jaac.2016.05.025. Epub 2016 Aug 5.
PMID:27663945
Abstract

Felix JF et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Hum Mol Genet. 2016 Jan 15;25(2):389-403. doi: 10.1093/hmg/ddv472. Epub 2015 Nov 24.
PMID: 26604143
Abstract

Paternoster L & Standl M et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 2015 Dec;47(12):1449-56. doi: 10.1038/ng.3424. Epub 2015 Oct 19. PMID: 26482879
Abstract

Pappa I et al. A genome-wide approach to children's aggressive behavior: The EAGLE consortium.
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):562-72. doi: 10.1002/ajmg.b.32333. Epub 2015 Jun 18.
PMID:26087016
Abstract

van der Valk RJ et al. A novel common variant in DCST2 is associated with length in early life and height in adulthood.
Hum Mol Genet. 2015 Feb 15;24(4):1155-68. doi: 10.1093/hmg/ddu510. Epub 2014 Oct 3.
PMID: 25281659
Abstract

Cousminer DL et al. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Hum Mol Genet. 2014 Aug 15;23(16):4452-64. doi: 10.1093/hmg/ddu150. Epub 2014 Apr 25.
PMID: 24770850
Abstract

van der Valk RJ et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul;134(1):46-55. doi: 10.1016/j.jaci.2013.08.053. Epub 2013 Dec 6. PMID: 24315451
Abstract

Bønnelykke K et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet. 2013 Aug;45(8):902-6. doi: 10.1038/ng.2694. Epub 2013 Jun 30.
PMID: 23817571
Abstract

Cousminer DL et al. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Hum Mol Genet. 2013 Jul 1;22(13):2735-47. doi: 10.1093/hmg/ddt104. Epub 2013 Feb 27.
PMID:23449627
Abstract

Horikoshi M et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nat Genet. 2013 Jan;45(1):76-82. doi: 10.1038/ng.2477. Epub 2012 Dec 2.
PMID:23202124
Abstract

Bradfield JP et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012 May;44(5):526-31. doi: 10.1038/ng.2247.
PMID:22484627
Abstract

Taal HR et al. Common variants at 12q15 and 12q24 are associated with infant head circumference.
Nat Genet. 2012 Apr 15;44(5):532-8. doi: 10.1038/ng.2238
PMID:22504419
Abstract

Paternoster L & Standl M et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2011 Dec 25;44(2):187-92. doi: 10.1038/ng.1017.
PMID: 22197932
Abstract

Freathy et al.: Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nature Genetics. 2010 May;42(5):430-5.
Abstract


top

Overview Projects

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.