ENRIECO (2009 – 2011)

Environmental Health Risks in European Birth Cohorts

Study objective:

  • Its overall aim is to advance our knowledge on specific environment and health causal relationships in pregnancy and birth cohorts.
  • Overall the focus is on exposure response relationships in environment and health in pregnancy and early childhood.
  • Extracting environmental exposure response relationships from existing data with some new work on specific environmental exposure response relationships.
  • To structure and consolidate often fragmented data from various studies undertaken throughout Europe in order to create a common inventory.
  • Data regarding environment-health causal relationships will be more readily available in a form useful for policy makers.

Specific aims:
To achieve the overall aims and objectives the work has been broken down into a number of work packages (WP). Figure 1 describes the specific tasks of each work package within the ENRIECO project.

  • Inventory of existing cohorts (health data, exposure data, biological samples, exposure response functions, expertise), including a searchable database.
  • To evaluate existing environmental exposure and health information, methods and tools, including assurance of quality and interoperability.
  • Evaluation of the existing environmental exposure response data, methods and tools, including assurance of quality and interoperability (HMGU).
  • To build databases, and conduct assurance of quality and interoperability, data access, analysis and validation.


Figure 1: Overview of the specific tasks of each work package within the ENRIECO project.

Study population:

25 birth cohorts from 20 European countries with data on questionnaire reported exposure and health data as well as clinical assessment from birth to current age (figure 2).

Figure 2: Location of European birth cohort studies collaborating in ENRIECO

Study period:
2009 - 2010

Current status:
The project is successfully completed and publications on the findings are currently ongoing.


Helmholtz Zentrum München – Deutsches Forschungszentrum
für Gesundheit und Umwelt GmbH (HMGU)
Centre for Research in Environmental Epidemiology (CREAL)Spain
Institut National de la Santé et de la Recherche Médicale (INSERM)France
Institute for Risk Assessment Sciences, Utrecht Universiteit (UU)The Netherlands
University of Crete (UoC)Greece
Karolinska Institute (KI)Sweden
Charité University Medical Centre BerlinGermany
Aarhus Universitetshospital, Aarhus SygehusDenmark




Dr. Joachim Heinrich

Helmholtz Zentrum München

German Research Center for Environmental Health    

Institute of Epidemiology
Ingolstädter Landstr. 1

D-85764 Neuherberg

Tel: +49 89 3187 4150

Fax: +49 89 3187 3380

Related Publications:

Tischer, C.G., Hohmann, C., Thiering, E., Herbarth, O., Müller, A., Henderson, J., Granell, R., Fantini, M.P., Luciano, L., Bergström, A., Kull, I., Link, E., von Berg, A., Kuehni, C.E., Strippoli, M.P., Gehring, U., Wijga, A., Eller, E., Bindslev-Jensen, C., Keil, T., Heinrich, J., ENRIECO consortium:
Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative.
Allergy. 2011 Dec;66(12):1570-9

Tischer, C., Chen, C.M., Heinrich, J.:
Association between domestic mould and mould components, and asthma and allergy in children: a systematic review.
Eur Respir J. 2011 Oct;38(4):812-24

Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C., Magnus, P., Majewska, R., Andersen, A.M., Patelarou, E., Petersen, M.S., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A.C., Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G., Wilhelm, M., Wright, J., Nieuwenhuijsen, M.:
European Birth Cohorts for Environmental Health Research.
Environ Health Perspect. 2011 Aug 29. [Epub ahead of print]

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