Munich Center of Health Sciences (MC-Health) (2006 – 2010)
Subproject 1.1: Genetic, lifestyle-dependent and social determinants of Health – Overweight in Childhood

Study objective:
To analyze the genetic, lifestyle-dependent and social determinants of health in an interdisciplinary approach of experts in their field from five faculties of the Ludwig Maximilians University Munich with a focus on population based medicine.
The first research focus is on overweight in childhood (subproject TP1.1) ; the second is on population related health in an aging society in particular cardio-vascular diseases (subproject TP1.2).

Specific aims:
For subproject TP1.1

  • Development of overweight in childhood within prospective children cohort studies and the National Childrens and Youth Survey on Health (nationaler Kinder- und Jugendgesundheitssurvey in Deutschland (KiGGS).
  • Investigation of genetics of overweight in childhood and identification of potential critical periods of life in respect to nutrion and liofestyle factors.
  • Prognostic modelling of the impact of children's overweight on overweight in adulthood by complex and innovative statistical models.
  • Evaluation of prevention programs and emhancing preventive efficacy/efficiency of these programs by new approaches of health communication.
  • Asssessment of costs related to the increase of overweight in the population and evaluation of the costs of such prevention programs.

Study design:

Analyzing population-based prospective birth cohorts (GINI-plus and LISA-plus) of healthy newborns followed up to age 10 comprising data from questionnaires, physical examinations and blood samples (genotyping, metabolic and inflammatory markers). Conducting utilization and cost analyses by using the national survey on childrens health (KIGGS) and collating additional data within the GINI-and LISA cohort studies. Systematic literature review to assess costs of prevention programs.

Study population:
Infants followed from birth up to age 10 in two German birth cohort studies (GINI/LISA) living in Munich, Wesel, Leipzig, and Bad Honnef comprising 9000 children and about 17000 of the national reprentative survey on health of children and adolecents (KIGGS).

Study area:

Study methods:
Anthropometric measurement of height and weight. Measurement of genetic variations, metabolic and inflamatory markers. Assessment of physical activity, sexual maturation, chronic stress, life events and ADHS. Reported socio-economic status, medical history, exposure to environmental toxicants including ETS is available for adjustment.
The analysis concept is based on a framework of longitudinal random coefficient models (multilevel models, frailty event models, generalized structural equation models) and generalized estimation equation models (GEE)) and will allow the analysis of the development, onset and remission of outcomes of subject-specific and population-averaged trajectories over the whole time course and tests of its temporal and causal structure.
Utilization and cost analyses is conducted by using the national survey on childrens health (KIGGS) and collating additional data within the GINI-and LISA Cohort studies. Systematic litaerture review are performed to assess costs of prevention programs.

Study period:
2006 – 2010

Dr. Joachim Heinrich, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
Prof. Dr. Reiner Leidl; Silke Wolfenstetter, Christina Wenig, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Health Economics and Health Care, Neuherberg, Germany
Prof. Dr. Rüdiger von Kries, Institute of Social Paediatrics and Adolescent Medicine, Ludwig Maximilians University Munich, Germany
Prof. Dr. Berthold Koletzko, Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Germany.

see above


  • BMFT, "Krankheitsbezogenes Kompetenznetzwerk Adipositas" (Obesity Network of Excellence)
  • GA2LEN network, WP1.5 "Birth cohorts". Pooled analyses on obesity and asthma in European birth cohorts  (P. Rzehak und J. Heinrich).
  • NGFN+ "Genetics of obesity" (J. Hebebrand, PI)
  • BMBF Forschungsverbund "Gesundheit im Alter", Konsortium "Long-term determinants and consequences of  multi-morbidty (KORA-AGE)": Untersuchung der Bestimmungsfaktoren und Folgen von Multimorbidität in einer bevölkerungsbasierten Kohortenstudie sowie eine sekundäre Präventionsmaßnahme bei Herzinfarktüberlebenden (Helmholtz Zentrum München, Institute für Epidemiologie und Gesundheitsökonomie mit LMU Innere Medizin, Umwelt- und Arbeitsmedizin und Pneumologie, TUM Psychosomatik und Psychiatrie sowie Klinikum Augsburg) 2008-2010
  • Nutricia Research Foundation - "Influence of genetic variants of the bitter-taste receptor gene TAS2R38 on the acceptance of hydrolysed infant formula and weight gain during the first 4 months of life" (J. Heinrich)

Joachim Heinrich
Helmholtz Zentrum München
German Research Center for Environmental Health

Institute of Epidemiology
Ingolstädter Landstr. 1
D-85758 Neuherberg
Tel. +49-(0)89-3187-4150
Fax +49-(0)89-3187-3380

Related publications:

Flexeder, C., Thiering, E., Brüske, I., Koletzko, S., Bauer, C.-P., Wichmann, H.-E., Mansmann, U., von Berg, A., Berdel, D., Krämer, U., Schaaf, B., Lehmann, I., Herbarth, O., Heinrich, J.. Growth velocity during infancy and onset of asthma in school-aged children. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02748.x

Rzehak P, Meisinger C, Woelke G, Brasche S, Strube G, Heinrich J. (2007)
Weight change, weight cycling and mortality in the ERFORT Male Cohort Study.
Eur J Epidemiol. 2007; 22: 665-73; [Epub ahead of print Aug 4].

Rzehak P, Heinrich J. (2006)
Development of relative weight, overweight and obesity from childhood to young adulthood. A longitudinal analysis of individual change of height and weight.
Eur J Epidemiol. 2006; 21:661-672.

Rzehak P, Heinrich J, Klopp N, Schaeffer L, Hoff S, Wolfram G, Illig T, Linseisen J .
Evidence for an association between genetic variants of the FADS1 FADS2 gene cluster and the fatty acid composition of red blood cell membranes.
In revision British Journal of Nutrition.

Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, G. Walters B, Thorsteinsdottir U, Kong A, Nguyen TT, Scherag A, Lichtner P, Meitinger T, Brönner B, Rief W, Soto-Quiros ME, Avila L, Klanderman B,  Raby BA, Silverman EK, Weiss ST, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper R, Fox C, O’Donnell C, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn J. (2007)
The association of a SNP upstream of INSIG2 with Body Mass Index is reproduced in several but not all cohorts.
PLoS Genet. 2007 Apr 27; 3(4):e61. Epub 2007 Mar 7. (Impact factor 13.9).

Heid IM, Vollmert C, Hinney A, Kronenberg F, Huth C, Pauler Ankerst D, Luchner A, Hinney A, Broenner G, Loewel H, Wichmann H-E, Illig T, Doering A, Hebebrand J. (2007)
A role of the MC4R 103I allele with features of the metabolic syndrome.
Obesity 2007, in press.

Leidl R.
Kritische Bewertung von gesundheitsökonomischen Studien. (2007)
In: Lehrbuch Evidenzbasierte Medizin in Klinik und Praxis (Hrsg.: Kunz R, Ollenschläger G, Raspe H, Jonitz G, Kolkmann F). 2. Auflage. Köln: Deutscher Ärzte-Verlag.

von Lengerke T, John J, for the KORA Study Group (2007).
General practitioners' opportunities for preventing ill health in healthy vs. morbid obese adults: a general population study on consultations.
J Public Health 15, 71-80.

von Lengerke T, John J, for the KORA Study Group. (2007)
Excess use of general practitioners by obese adults: Does health-related quality of life account for the association?
Psychology, Health & Medicine 12 (5), 536 - 544.

Neubauer S, Welte R, Beiche A, König HH, Büsch K, Leidl R (2006). Smoking-attributable mortality, morbidity and costs in Germany: Update and 10 year comparison. Tobacco Control 15(6):464-71.

Neubauer S, Steinle T, Gapp O, König HH, Leidl R (2007).
Informationsbasis für die Abschätzung von gesundheitspolitischen und wirtschaftlichen Folgen von Tabakkontrollmaßnahmen in Deutschland.
Sozialer Fortschritt 56(11):271-279.

Quentin W, Neubauer S, Leidl R, König HH (2007).
Advertising bans as a means of tobacco control policy: a systematic literature review of time-series analyses.
International Journal of Public Health (52)5: 295-307.

Rogowski W (2007).
Current impact of gene technology on healthcare. A map of economic assessments.
Health Policy 80 (2), 340-357.

Schweikert B, Seitz R, Osthus H, Cziske R, Walker A, Jacobi E, Knab J, Leidl R (2006).
Effectiveness and cost-effectiveness of an additional psychological treatment in the rehabilitation of chronic low back pain.
Journal of Rheumatology 33(12):2519–26.

Stark R, König HH, Leidl R (2006).
Costs of inflammatory bowel disease in Germany based on a Cost Diary.
Pharmacoeconomics 24(8):797-814.

von der Schulenburg JM, Greiner W, Jost F, Klusen N, Kubin M, Leidl R, Mittendorf T, Rebscher H, Schoeffski O, Vauth C, Volmer T, Wahler S, Wasem J, Weber C und die Mitglieder der Hannoveraner Konsensgruppe (2007).
Deutsche Empfehlungen zur gesundheitsökonomischen Evaluation - dritte und aktualisierte Fassung des Hannoveraner Konsens.
Gesundheitsökonomie und Qualitätsmanagement 12(5):285-290.

von der Schulenburg JM, Greiner W, Jost F, Klusen N, Kubin M, Leidl R, Mittendorf T, Rebscher H, Schoeffski O, Vauth C, Volmer T, Wahler S, Wasem J, Weber C, and the Hanover Consensus Group (2007).
German recommendations on health economic evaluation – Third and updated version of the Hanover Consensus.
Value in Health (accepted).

Wolfenstetter S (2006).
Adipositas und die Komorbidität Diabetes mellitus Typ 2 bei Kindern und Jugendlichen in Deutschland: Entwicklung und Krankheitskostenanalyse.
Das Gesundheitswesen 68, 600-612.


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