TRAPCA (1998 – 2010)

Risk assessment of exposure to traffic-related air pollution for the development of inhalant allergies, asthma and other chronic respiratory conditions in children

Study objective:
To assess the risk of exposure to traffic-related air pollution on the development of inhalant allergies, asthma and other chronic respiratory conditions in children.

Specific aims:
Children with high exposure to traffic-related air pollution have a higher risk to develop inhalant allergies, and/or asthma, and/or other chronic respiratory conditions than children with low exposure.

Study design:
Components to be estimated are NO2, PM2.5, and the reflectance of PM2.5 filters. In total, 40 measurement sites for PM2.5 and NO2 were selected. Four 2-week measurement periods spread over one year were chosen for each site. To ‘calibrate’ discontinuous measurements continuous measurements at one additional site were taken for the full year of study. Traffic-related variables (for example population density and traffic intensity) were collected using Geographical Information Systems and used in regression models predicting annual average concentrations. These models were then used to estimate ambient air concentrations at the home addresses of the cohort members.

Study population:
Children from two birth cohort studies (GINI/LISA) living in Munich.

Study area:
Some of the children live in the central part of Munich, others in more suburban areas.

Study period:
1997 - 2010.

Current status:
Ongoing.

Investigators:
Joachim Heinrich

Collaboration:
Gerard Hoek, Kees Meliefste, Mike Brauer, Patricia van Vliet, Bert Brunekreef (coordinator)
Institute for Risk Assessment Sciences, Utrecht University – The Netherlands

Paul Fischer, Erik Lebret
Laboratory of Exposure Assessment and Environmental Epidemiology
National Institute of Public Health and the Environment, Bilthoven – The Netherlands

Marie Lewné, Tom Bellander, Göran Pershagen
Department Environmental Health
Stockholm County Council and Karolinska Institute - Sweden

Funding:
EU

Contact:
Helmholtz Zentrum München
Institute of Epidemiology
Marie Standl
P.O. Box 1129
D-85758 Neuherberg
Tel. +49-(0)89-3187-2952
Fax +49-(0)89-3187-3380

Related publications:

Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, Behrendt H, Herbarth O, von Berg A, Bauer CP, Wichmann HE, Heinrich J, Gini And Lisa Study Group:
Atopic Diseases, Allergic Sensitisation and Exposure to Traffic-Related Air Pollution in Children.
Am J Respir Crit Care Med. 2008 Jun 15;177(12):1331-7.
Abstract

Morgenstern V, Zutavern A, Cyrys J, Brockow I, Gehring U, Koletzko S, Bauer CP, Reinhardt D, Wichmann HE, Heinrich J:
Respiratory health and individual estimated exposure to traffic-related air pollutants in a cohort of young children.
Occup Environ Med. 2007; 64(1):8-16.
Abstract

Brauer M, Gehring U, Brunekreef B, de Jongste J, Gerritson J, Rovers M, Wichmann HE, Wijga A, Heinrich J:
Traffic-related air pollution and otitis media.
Environmental Health Perspectives 2006; 114/9:1414-18.
Abstract

Heinrich J, Wichmann HE:
Traffic related pollutants in Europe and their effect on allergic disease.
Current Opinion in Allergy and Clinical Immunology 2004; 4:341-348.
Abstract

Brauer M, G Hoek, P van Vliet, K Meliefste, P Fischer, U Gehring, J Heinrich, J Cyrys, T Bellander, M Lewne, B Brunekreef.
Estimating long term average particulate air pollution concentrations for epidemiological studies: Application of traffic indicators and Geographic Information Systems.
Epidemiology 2003; 14: 228-239.
Abstract

Cyrys J, J Heinrich, K Meliefste, M Lewne, G Hoek, T Bellander, P Fischer, U Gehring, P van Vliet, M Brauer, HE Wichmann, B Brunekreef.
Comparison between different traffic related particle indicators: elemental carbon (EC), PM2.5 mass and absorbance.
Journal of Exposure Analysis and Environmental Epidemiology 2003; 13: 134-143.
Abstract

Cyrys J, J Heinrich, K Meliefste, M Lewne, G Hoek, T Bellander, P Fischer, U Gehring, P van Vliet, M Brauer, HE Wichmann, B Brunekreef.
Comparison between different traffic related particle indicators: elemental carbon (EC), PM2.5 mass and absorbance.
Journal of Exposure Analysis and Environmental Epidemiology 2003; 13: 134-143.
Abstract

Gehring U, J Cyrys, G Sedlmeir, B Brunekreef, T Bellander, P Fischer, CP Bauer, D Reinhardt, HE Wichmann, J Heinrich.
Traffic-related air pollution and respiratory health during the first 2 years of life.
Eur Respir J 2002; 19: 690-698.
Abstract

Cyrys J, J Heinrich, K Meliefste, M Lewne, G Hoek, T Bellander, P Fischer, U Gehring, P van Vliet, M Brauer, HE Wichmann, B Brunekreef. Comparison between different traffic related particle indicators: elemental carbon (EC), PM2.5 mass and absorbance. Journal of Exposure Analysis and Environmental Epidemiology 2003; 13: 134-143.
Abstract

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