Project

CATHGEN: "CATHeterization GENetics Research Project“

Project description: http://dmpi.duke.edu/cathgen

Related HEI project “Air quality by genomics interactions in a cardiovascular disease cohort”: http://www.healtheffects.org/ongoing.htm#Experimental



Objectives:
This project is designed to investigate the effects of acute and chronic air pollution exposure on acute and chronic cardiovascular disease. Gene-by-air quality effects on newly identified cardiovascular risk biomarkers and blood-based whole genome gene expression profiles as biological mediators of acute cardiovascular events (myocardial infarction and hospitalization) and cardiovascular disease state (extent of coronary artery atherosclerosis) will be examined.

For this purpose the CATHGEN cohort of 9323 individuals undergoing coronary artery catheterization (collected 2001-2011) is used for analyses. The CATHGEN cohort, collected at Duke, includes individuals with and without coronary atherosclerosis.

The research is driven by three hypotheses: 1) Air quality, including PM2.5 and ozone, are related to prevalence of chronic cardiovascular disease (both coronary and peripheral) and incidence of acute cardiovascular events; 2) Specific genetic variants mediate the interaction of air quality and cardiovascular disease and incident events; 3) The interaction of genetic variants and air quality on cardiovascular disease and incidence events are in turn mediated by air quality-induced modifications of gene expression and circulating metabolic intermediates.

The Institute of Epidemiology II focuses on the investigation of acute and chronic effects of exposure to PM2.5, PM components, ozone and air temperature on cardiovascular events and biomarkers of cardiovascular risk including ECG- and blood parameters, metabolites and lipoproteins.

Current status:
ongoing

Funding period:
2014– ongoing

Investigators/Coordination:
Duke University - School of Medicine: William Kraus (PI)
U.S. Environmental Protection Agency (EPA) –National Health and Environmental Effects Research Laboratory (NHEERL), Environmental Public Health Division (EPHD): Robert B. Devlin, David Diaz-Sanchez
Helmholtz Zentrum München - Institute of Epidemiology: Alexandra Schneider, Susanne Breitner, Regina Hampel, Siqi Zhang

Funding:
Duke University
U.S. EPA

Contact:
Alexandra Schneider, PhD
Phone +49 89 3187-3512
Fax +49 89 3187-3380


Related publications:


McGuinn LA, Ward-Caviness C, Neas LM, Schneider A, Di Q, Chudnovsky A, Schwartz J, Koutrakis P, Russell AG, Garcia V, Kraus WE, Hauser ER, Cascio W, Diaz-Sanchez D, Devlin RB. Fine particulate matter and cardiovascular disease: Comparison of assessment methods for long-term exposure. Environ Res. 2017;159:16-23.
Abstract

Ward-Caviness CK, Neas LM, Blach C, Haynes CS, LaRocque-Abramson K, Grass E, Dowdy ZE, Devlin RB, Diaz-Sanchez D, Cascio WE, Miranda ML, Gregory SG, Shah SH, Kraus WE, Hauser ER. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. PLoS One. 2017;12(3):e0173880.
Abstract

Breitner S, Schneider A, Devlin RB, Ward-Caviness CK, Diaz-Sanchez D, Neas LM, Cascio WE, Peters A, Hauser ER, Shah SH, Kraus WE. Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort. Environ Int. 2016;97:76-84.
Abstract

Hampel R, Breitner S, Kraus WE, Hauser E, Shah S, Ward-Caviness CK, Devlin R, Diaz-Sanchez D, Neas L, Cascio W, Peters A, Schneider A. Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization. Environ Res. 2016 Nov;151:224-232.
Abstract

Ward-Caviness CK, Neas LM, Blach C, Haynes CS, LaRocque-Abramson K, Grass E, Dowdy E, Devlin RB, Diaz-Sanchez D, Cascio WE, Lynn Miranda M, Gregory SG, Shah SH, Kraus WE, Hauser ER. Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One. 2016 Apr 15;11(4):e0152670.
Abstract

McGuinn LA, Ward-Caviness CK, Neas LM, Schneider A, Diaz-Sanchez D, Cascio WE, Kraus WE, Hauser E, Dowdy E, Haynes C, Chudnovsky A, Koutrakis P, Devlin RB. Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease. Environ Res. 2016 Feb;145:9-17.
Abstract


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