Previous Project

MOHIT: "Mortality, myocardial infarction and air temperature in Bavaria" (2008 - 2009)

Study objective:
The study aims at assessing the impact of air temperature on daily cause-specific mortality and morbidity in Bavaria between 1990 and 2006. A second aim is to identify subpopulations with increased susceptibility to air temperature effects, which might have special needs for public health actions in Bavaria in times of ongoing climate change.

Specific aims:
Determine the association between ambient air temperature and: 

  • Daily total as well as cause-specific mortality rates in Bavarian cities and counties with more than 200.000 inhabitants
  • Daily registry-based myocardial infarction (MI) rates in the area of Augsburg, Germany
  • Daily cardiovascular symptom occurrence in the area of Augsburg, Germany, between 2003 and 2004

Study design:

Population-based time-series mortality and morbidity study.

Study population:
Residents of the Bavarian cities Munich, Nuremberg and Augsburg, and residents of the counties (Landkreise) Munich, Augsburg, Aichach-Friedberg, Fürstenfeldbruck and Rosenheim.

Study area:
Bavarian cities Munich, Nuremberg and Augsburg, and counties (Landkreise) Munich, Augsburg, Aichach-Friedberg, Fürstenfeldbruck and Rosenheim.

Study methods:
Exposure assessment:

  • Daily mean, maximum and minimum air temperature, apparent temperature, dew point temperature, relative humidity, barometric pressure, wind, and precipitation based on hourly measurements obtained from Deutscher Wetterdienst (DWD) (German weather service).
  • Heat waves and cold spells.

Health outcome:

  • Daily counts of total mortality and cause-specific mortality due to cardiovascular and respiratory causes.
  • Daily counts of myocardial infarctions and coronary deaths based on the KORA Registry Augsburg (Link to KORA)
  • Daily occurrence of cardiovascular symptoms of 180 Augsburg residents obtained in the course of the project AIRGENE between May 2003 and February 2004.

Statistical Methods:

  • Generalized semi-parametric models
  • Distributed lag models
  • Time-varying coefficient models
  • Interaction analysis / effect modification analysis
  • Meta-smoothing
  • Piecewise regression

Study period:

1990 – 2006.

Current status:

Helmholtz Zentrum München - Institute of Epidemiology II: Alexandra Schneider (PI), Susanne Breitner, Kathrin Wolf, Annette Peters, H.-Erich Wichmann.

Bavarian State Ministry of the Environment and Public Health.

Related publications:

  • Final Report (german; pdf)

  • Short-term effects of air temperature on cause-specific cardiovascular mortality in Bavaria, Germany.
    Breitner S, Wolf K, Peters A, Schneider A.
    Heart. 2014 Aug;100(16):1272-80. doi: 10.1136/heartjnl-2014-305578. Epub 2014 Jun 6.

  • Short-term effects of air temperature on mortality and effect modification by air pollution in three cities of Bavaria, Germany: a time-series analysis.
    Breitner S, Wolf K, Devlin RB, Diaz-Sanchez D, Peters A, Schneider A.
    Sci Total Environ. 2014 Jul 1;485-486:49-61. doi: 10.1016/j.scitotenv.2014.03.048. Epub 2014 Apr 2.

  • Air temperature and the occurrence of myocardial infarction in Augsburg, Germany.
    Wolf, K, Schneider, A, Breitner, S, von Klot, S, Meisinger, C, Cyrys, J, Hymer, H, Wichmann, HE, Peters, A.
    Circulation 2009 Sep 1;120(9):735-42.