News

28.07.2016

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

An international team of researchers from the Institute of Computational Biology (ICB) and ETH Zurich has been studying two transcription factors influencing the differentiation of blood cells in time lapse movies. Their quantitative analysis of protein levels over time in single blood stem cells shows that certain molecular mechanisms are not as relevant as previously assumed. This finding helps to improve our understanding of cellular differentiation and of hematopoietic diseases such as leukaemia and anaemia. The study is published in Nature.

For more information see the original publication: Hoppe, P.S.; Schwarzfischer, M.; Loeffler, D. et al. Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios. Nature 535, 299-302 (2016)
and the press release by the Helmholtz Zentrum.

To find out more about the work of groups in the ICB, visit the institute webpage here