Personalisierte Radiotherapie bei Kopf-Hals-Tumoren

Komplette Liste bei PubMed

2017

Brix N, Tiefenthaller A, Anders H, Belka C, Lauber K, Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences.
Immunological Reviews, in press

Englhard AS, Palaras A, Volgger V, Stepp H, Mack B, Libl D, Gires O, Betz CS.
Confocal laser endomicroscopy in head and neck malignancies using FITC-labelled
EpCAM- and EGF-R-antibodies in cell lines and tumor biopsies. Journal of
biophotonics. 2017; 10(10):1365-1376. PubMed [journal] PMID: 28106950

Orth M, Unger K, Schoetz U, Belka C, Lauber K. Taxane-mediated radiosensitization
derives from chromosomal missegregation on tripolar mitotic spindles orchestrated
by AURKA and TPX2. Oncogene. 2017; PubMed [journal] PMID: 28869599

Lin PP, Gires O, Wang DD, Li L, Wang H. Comprehensive in situ co-detection of
aneuploid circulating endothelial and tumor cells. Scientific reports. 2017;
7(1):9789. PubMed [journal] PMID: 28852197

Steens J, Zuk M, Benchellal M, Bornemann L, Teichweyde N, Hess J, Unger K,
Görgens A, Klump H, Klein D. In Vitro Generation of Vascular Wall-Resident
Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem
Cells. Stem cell reports. 2017; 8(4):919-932. PubMed [journal] PMID: 28366456

Gires O. EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Letter.
Cancer research. 2017; 77(7):1775-1776. PubMed [journal] PMID: 28330930

Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I,
Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler
GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber
K. Genomic amplification of Fanconi anemia complementation group A (FancA) in
head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of
radioresistance and clinical relevance. Cancer letters. 2017; 386:87-99. PubMed
[journal] PMID: 27867017

Wang H, Stoecklein NH, Lin PP, Gires O. Circulating and disseminated tumor cells:
diagnostic tools and therapeutic targets in motion. Oncotarget. 2017;
8(1):1884-1912. PubMed [journal] PMID: 27683128

Baumeister P, Rauch J, Jacobi C, Kisser U, Betz C, Becker S, Reiter M. Impact of
comorbidity and anemia in patients with oropharyngeal cancer primarily treated
with surgery in the human papillomavirus era. Head & neck. 2017; 39(1):7-16.
PubMed [journal] PMID: 27385398

2016

Linge A, Lohaus F, Löck S, Nowak A, Gudziol V, Valentini C, von Neubeck C, Jütz
M, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Grosu AL,
Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips
D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard
J, Krause M, Baumann M. HPV status, cancer stem cell marker expression, hypoxia
gene signatures and tumour volume identify good prognosis subgroups in patients
with HNSCC after primary radiochemotherapy: A multicentre retrospective study of
the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Radiotherapy
and oncology : journal of the European Society for Therapeutic Radiology and
Oncology. 2016; 121(3):364-373. PubMed [journal] PMID: 27913065

Rauch J, Vandamme D, Mack B, McCann B, Volinsky N, Blanco A, Gires O, Kolch W.
Differential localization of A-Raf regulates MST2-mediated apoptosis during
epithelial differentiation. Cell death and differentiation. 2016; 23(8):1283-95.
PubMed [journal] PMID: 26891695

Michna A, Schötz U, Selmansberger M, Zitzelsberger H, Lauber K, Unger K, Hess J.
Transcriptomic analyses of the radiation response in head and neck squamous cell
carcinoma subclones with different radiation sensitivity: time-course gene
expression profiles and gene association networks. Radiation oncology (London,
England). 2016; 11:94. PubMed [journal] PMID: 27455841

Niyazi M, Pitea A, Mittelbronn M, Steinbach J, Sticht C, Zehentmayr F, Piehlmaier
D, Zitzelsberger H, Ganswindt U, Rödel C, Lauber K, Belka C, Unger K. A 4-miRNA
signature predicts the therapeutic outcome of glioblastoma. Oncotarget. 2016;
7(29):45764-45775. PubMed [journal] PMID: 27302927

Caldwell RB, Braselmann H, Schoetz U, Heuer S, Scherthan H, Zitzelsberger H.
Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40
cells. Scientific reports. 2016; 6:28890. PubMed [journal] PMID: 27374870

Wurster S, Hennes F, Parplys AC, Seelbach JI, Mansour WY, Zielinski A, Petersen
C, Clauditz TS, Münscher A, Friedl AA, Borgmann K. PARP1 inhibition
radiosensitizes HNSCC cells deficient in homologous recombination by disabling
the DNA replication fork elongation response. Oncotarget. 2016; 7(9):9732-41.
PubMed [journal] PMID: 26799421

Unkel S, Belka C, Lauber K. On the analysis of clonogenic survival data:
Statistical alternatives to the linear-quadratic model. Radiation oncology
(London, England). 2016; 11:11. PubMed [journal] PMID: 26822015

Klein D, Schmetter A, Imsak R, Wirsdörfer F, Unger K, Jastrow H, Stuschke M,
Jendrossek V. Therapy with Multipotent Mesenchymal Stromal Cells Protects Lungs
from Radiation-Induced Injury and Reduces the Risk of Lung Metastasis.
Antioxidants & redox signaling. 2016; 24(2):53-69. PubMed [journal] PMID:
26066676

Buchfellner A, Yurlova L, Nüske S, Scholz AM, Bogner J, Ruf B, Zolghadr K,
Drexler SE, Drexler GA, Girst S, Greubel C, Reindl J, Siebenwirth C, Romer T,
Friedl AA, Rothbauer U. A New Nanobody-Based Biosensor to Study Endogenous PARP1
In Vitro and in Live Human Cells. PloS one. 2016; 11(3):e0151041. PubMed
[journal] PMID: 26950694

Michna A, Braselmann H, Selmansberger M, Dietz A, Hess J, Gomolka M, Hornhardt S,
Blüthgen N, Zitzelsberger H, Unger K. Natural Cubic Spline Regression Modeling
Followed by Dynamic Network Reconstruction for the Identification of
Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome
Data. PloS one. 2016; 11(8):e0160791. PubMed [journal] PMID: 27505168

Penterling C, Drexler GA, Böhland C, Stamp R, Wilke C, Braselmann H, Caldwell RB,
Reindl J, Girst S, Greubel C, Siebenwirth C, Mansour WY, Borgmann K, Dollinger G,
Unger K, Friedl AA. Depletion of Histone Demethylase Jarid1A Resulting in Histone
Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand
Break Repair. PloS one. 2016; 11(6):e0156599. PubMed [journal] PMID: 27253695

2015

Sass S, Pitea A, Unger K, Hess J, Mueller NS, Theis FJ. MicroRNA-Target Network
Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters
with Distinct Functions in Head and Neck Squamous Cell Carcinoma. International
journal of molecular sciences. 2015; 16(12):30204-22. PubMed [journal] PMID:
26694379

Braselmann H, Michna A, Heß J, Unger K. CFAssay: statistical analysis of the
colony formation assay. Radiation oncology (London, England). 2015; 10:223.
PubMed [journal] PMID: 26537797

Tsaktanis T, Kremling H, Pavšič M, von Stackelberg R, Mack B, Fukumori A, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarčič B, Gires O. Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM). J Biol Chem. 2015 Oct 2;290(40):24574-91. doi: 10.1074/jbc.M115.662700. Epub 2015 Aug 19. Erratum in: J Biol Chem. 2016 Jan 1;291(1):425. PMID: 26292218

Summerer I, Hess J, Pitea A, Unger K, Hieber L, Selmansberger M, Lauber K,
Zitzelsberger H. Integrative analysis of the microRNA-mRNA response to
radiochemotherapy in primary head and neck squamous cell carcinoma cells. BMC
genomics. 2015; 16:654. PubMed [journal] PMID: 26328888

Selmansberger M, Feuchtinger A, Zurnadzhy L, Michna A, Kaiser JC, Abend M,
Brenner A, Bogdanova T, Walch A, Unger K, Zitzelsberger H, Hess J. CLIP2 as
radiation biomarker in papillary thyroid carcinoma. Oncogene. 2015;
34(30):3917-25. PubMed [journal] PMID: 25284583

Summerer I, Unger K, Braselmann H, Schuettrumpf L, Maihoefer C, Baumeister P,
Kirchner T, Niyazi M, Sage E, Specht HM, Multhoff G, Moertl S, Belka C,
Zitzelsberger H. Circulating microRNAs as prognostic therapy biomarkers in head
and neck cancer patients. British journal of cancer. 2015; 113(1):76-82. PubMed
[journal] PMID: 26057452

Eke I, Zscheppang K, Dickreuter E, Hickmann L, Mazzeo E, Unger K, Krause M,
Cordes N. Simultaneous β1 integrin-EGFR targeting and radiosensitization of human
head and neck cancer. Journal of the National Cancer Institute. 2015; 107(2).
PubMed [journal] PMID: 25663685

2014

Unger K. Integrative radiation systems biology. Radiation oncology (London,
England). 2014; 9:21. PubMed [journal] PMID: 24411063

Maroschik B, Gürtler A, Krämer A, Rößler U, Gomolka M, Hornhardt S, Mörtl S,
Friedl AA. Radiation-induced alterations of histone post-translational
modification levels in lymphoblastoid cell lines. Radiation oncology (London,
England). 2014; 9:15. PubMed [journal] PMID: 24406105

Schoetz U, Deliolanis NC, Ng D, Pauli J, Resch-Genger U, Kühn E, Heuer S, Beisker
W, Köster RW, Zitzelsberger H, Caldwell RB. Usefulness of a Darwinian system in a
biotechnological application: evolution of optical window fluorescent protein
variants under selective pressure. PloS one. 2014; 9(9):e107069. PubMed [journal]
PMID: 25192257

2013

Summerer I, Niyazi M, Unger K, Pitea A, Zangen V, Hess J, Atkinson MJ, Belka C,
Moertl S, Zitzelsberger H. Changes in circulating microRNAs after
radiochemotherapy in head and neck cancer patients. Radiation oncology (London,
England). 2013; 8:296. PubMed [journal] PMID: 24373621

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