Virtuelles Seminar mit Michelle Vincendau: 'Human Endogenous Retroviruses impact Neuronal Differentiation'

22.07.2021 - 22.07.2021 | 16:00 - 17:00
Michelle Vincendau, Institut für Virologie
Helmholtz Zentrum München
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Silvia Sironi, PhD
Science Communication Manager
Helmholtz Zentrum München
E-Mail: silvia.sironi@helmholtz-muenchen.de

© Helmholtz Zentrum München

The biological function and disease association of human endogenous retroviruses (HERVs) are largely elusive. HERV-K(HML-2) has been associated with neurotoxicity, but there is no clear understanding of its role or mechanistic basis. In a new study, Vincendeau et al, addressed the physiological functions of HERV-K(HML-2) in neuronal differentiation using CRISPR engineering to activate or repress its expression levels in a human-pluripotent-stem-cell-based system. Vincendeau et al found that activation of HERV-K(HML-2) disrupts cortical neuron differentiation and function.

Link to the publication: www.sciencedirect.com/science/article/abs/pii/S1934590921001661