metaP Initiative

The Metabolomic Platform (metaP) is a scientific interdisciplinary cooperation of Institutes of the Helmholtz Zentrum München.

Within the metaP initiative we include targeted and untargted metabolic profiling as well deep metabotyping. These activities are possible by the unique contributions of participating Helmholtz Zentrum München institutes: robotics and analyte quantification (GC-MS, LC-MS/MS QTrap; Prof. Dr. Jerzy Adamski, IEG, ), ultra-high resolution based deep metabotyping (FTICR-MS, LC-MS, NMR; Prof Dr. Philippe Schmitt-Kopplin, BGC, ),  and bioinformatics/project integration (Dr. Gabi Kastenmüller, IBIS, ). 

We successfully performed studies in the population based human KORA (Cooperative Health Research in the Region of Augsburg) cohort and in animal models in elucidating metabolomic effects in complex diseases or drug development, respectively.

The non-targeted approaches are followed in a lower throughput using two-dimensional chromatography coupled to mass spectrometry and flow injection ultrahigh resolution mass spectrometry with various ionization modes. We established the MassTRIX web-service (http://masstrix.org) annotating metabolite elemental compositions from ultrahigh resolution mass spectrometry data in their genomic context on KEGG pathway maps. Processing of data from targeted metabolomics experiments can be done at our automated server (http://metabolomics.helmholtz-muenchen.de/metap2/).

In summary we do metabolomics research on different levels with different throughput capabilities:

  • Targeted and non-targted metabolic profiling
  • Deep metabotyping
  • Bioinformatics and data integration

 

 

Graphic by Jerzy Adamski