Scientific highlights

21.05.2021

New endocrine connection between the liver and adipose tissue

Congratulations to Anastasia Georgiadi, Stephan Herzig et al from the IDC for their new publication in Nature Communications.

 Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.

"The communication between  tissues is critical for maintainance of metabolic homeostasis. In this work we show that the liver derived, soluble bioactive part of fincronectin type III domain contain 4 (FNDC4) signals through the adipose tissue receptor GPR116 to promote insulin-mediated glucose uptake." - Anastasia Georgiadi