Methods

Here you can find an overview of the methods applied at the Leipzig University for and during the clinical trials:

Bioelectrical Impedance Analysis (BIA measurement)

Bioelectrical impedance analysis is an electrical resistance measurement of the human body and allows the estimation of the proportions of muscle and fat tissue in the body, as well as the body fat content.

Blood Pressure Measurement

During the blood pressure measurement the pressure in the arteries will be taken to determine the systolic and diastolic blood pressure. This may indicate a possible hypertension and relating thereto risks of disease of the cardiovascular system.

Determination of Anthropometric Characteristics

The determination of anthropometric characteristics, e. g. the body weight, height and girths, allows a basal characteristic of the trial participants.

Determination of Blood and Urine Parameters

Blood and urine parameters are informative about the state of health, may indicate a possible disease and risks of disease, and the effects of a therapy can be controlled. The determination of the measurement parameters will be made at the Institute for Laboratory Medicine of the University Hospital Leipzig.

Digital Photoplethysmography

With this method the functionality of the venous valves can be checked, e. g. when suffering from varicose veins.

Eating Behaviour Questionnaire

Through a test battery with different eating behaviour questionnaires, different aspects of eating behaviours, e. g. the hunger sensations, deliberate restrictions in food intake, intuitive eating and pathological eating behaviours, can be recorded.

Electrocardiography

During the measurement, the sum of the electrical activities of all cardiac muscle fibers is displayed graphically. Thus a wide range of conclusions can be drawn about the cardiac function.

Endothelial Measurement

The method of endothelial measurement is used to assess arterial stiffness and provides information about the endothelial function.

Food / Nutritional Protocol

Food / nutritional protocols allows to record the eating habits in quality and quantity at home and through a software the intake of macro and micro nutrients can be quantified.

Hyperspectral Imaging

This method is used to assess the tissue oxygen saturation and provides information on microcirculation.

Indirect Caloriemetry

Indirect caloriemetry is used to measure the oxygen consumption of an organism. This is the basis for the determination of the energy metabolism.

Laser Speckle Contrast Analysis

This method allows the analysis of microcirculation.

Measurement of the Ankle-Arm-Index

This measurement is a screening method to check for the presence of peripheral arterial disease (PAD).

Metabolic Function Test

Oral glucose tolerance test, insulin clamp test: These tests measure the body's insulin sensitivity and insulin response to carbohydrates. 

Odor Test

The sense of smell will be measured qualitatively through different smell samples.

Optical Pulse Oscillography

This method allows an assessment of the blood flow in the finger and toe arteries.

Physical Activity

Accelerometers in the form of a wristband are used to measure physical activity throughout the day.

Puls Wave Analysis (PWA)

The pulse wave analysis (PWA) is used for the assessment of the arterial stiffness and provides information about endothelial function.

Snack Food Taste Test

The food intake of certain foods in an already satiated state will be recorded qualitatively and quantitatively.

Standardized Test Meal

Via the standardized test meal, the calorie intake via specific foods with the possibility of differentiation into the various macronutrients is recorded qualitatively and quantitatively in a hungry state.

Taste Test

The sense of taste will be measured qualitatively and quantitatively via different taste strips.

Vascular Ultrasound

This method allows to determine organic and functional vascular changes in arteries as well as in veins.

Vein Occlusion Plethysmography

This method is used to measure the outflowing venous blood and provides information about any outflow obstructions, such as after a thrombosis.