Welcome to IAF

About IAF

  • The research of The Institute of Allergy Research (IAF) is focused on the understanding of mechanisms involved in the development of allergies and allergen tolerance in the context of genetic predisposition, immune system and environmental factors. As part of the Center of Allergy & Environment (ZAUM) the IAF conducts applied, clinical and basic research. The aim of the research is to understand the mechanisms of allergic diseases, to assess risks for the onset of allergy as well as to develop novel strategies for prevention und therapy. 

    The Center for Allergy & Environment (ZAUM) in Munich is a hybrid institution build by the IAF at the Helmholtz Zentrum Munich and the chair of Molecular Allergology of the School of Medicine, Technical University of Munich. This link of governmental research and university medicine, which is unique in the German research landscape, serves the interdisciplinary basic research and builds a link to the clinic and clinical studies. This translational approach enables new insights into molecular mechanisms of allergies and their translation into new strategies for their prevention and patient-tailored therapy.

Highlights

Allergieinformationsdienst - Evaluierung

Liebe Besucherinnen und Besucher unserer Website,

kennen Sie den Allergieinformationsdienst? Er wurde seit 2017 am Helmholtz Zentrum München mit Mitteln des Bundesgesundheitsministeriums aufgebaut. Der Allergieinformationsdienst bietet aktuelle, wissenschaftlich geprüfte Information aus allen Bereichen der Allergieforschung und Allergologie in verständlich aufbereiteter Form über das Internet an. Mittlerweile nutzen monatlich viele tausend Menschen die Informationen des Allergieinformationsdienstes. Um das Angebot bestmöglich den Bedürfnissen der Nutzer anzupassen, wird im Rahmen einer begleitenden Evaluierung untersucht, auf welche Weise Menschen Informationen zum Thema Gesundheit im Allgemeinen und zum Thema Allergien im Besonderen suchen, und ob sie mit den derzeit verfügbaren Informationsmöglichkeiten insbesondere auch beim Allergieinformationsdienst zufrieden sind. 

Dafür ist Ihre Unterstützung nötig. Wir bitten Sie, sich zehn Minuten Zeit zu nehmen, und an der online-Befragung zu Gesundheitsinformationen im Internet und insbesondere zum Angebot des Allergieinformationsdienstes teilzunehmen. Damit tragen Sie dazu bei, das Internetangebot zu Gesundheitsinformationen auch in Zukunft noch weiter zu verbessern. Vielen Dank für Ihre Teilnahme! 

Link: https://www.soscisurvey.de/allid4/?r=C&q=q1

Bavarian ePIN pollen measurement system

Today the Bavarian Minister of Health Dr Huml officially started the "ePIN" pollen measurement system in Bavaria. The world wide unique system generates now online pollen data to support allergy sufferers during the pollen season. Prof. Dr. J. Buters from Poing was the initiator and head of the preliminary studies leading to this network. The LGL has built the network and will operate it long term.

Pollen flight

www.epin.bayern.de

Video

http://webcast.eaaci.cyim.com/mediatheque/media.aspx?mediaId=46284&channel=8518

New article on experimental allergen-specific immunotherapy published in Allergy

Allergen-specific immunotherapy (AIT) is the only causal treatment for allergy. However, success rates vary depending on the type of allergy and disease background of the patient. Hence, strategies targeting an increased therapeutic efficacy are urgently needed. The research group of Simon Blank in collaboration with the German Mouse Clinic at the Helmholtz Center Munich (first authors: Dennis Russkamp and Antonio Aguilar-Pimentel) used an recombinantly produced IL-4 and IL-13 antagonist (IL-4 Mutein) to block IL-4 and Il-13 signaling during experimental AIT of murine allergic asthma. Using this strategy, they were able to demonstrate that IL-4 and IL-13 blockade during AIT shows beneficial effects on immunological key parameters such as IgE, IgG and Th2 cytokine secretion as well as significantly decreases the number of potentially disease-triggering Th2-biased Tregs (ST2+FOXP3+GATA3intermediate). Hence, Th2 cytokine-inhibiting strategies might be suitable to support allergen-specific immunotherapy in a therapy success-favoring manner.

IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma

D. Russkamp, A. Aguilar-Pimentel, F. Alessandrini, V. Gailus-Durner, H. Fuchs, C. Ohnmacht, A. Chaker, M. Hrabe de Angelis, M. Ollert, C. B. Schmidt-Weber, S. Blank

Allergy 2019, Epub ahead pf print.

www.ncbi.nlm.nih.gov/pubmed/30829405

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