Metabolomics

Dr. Matthias Arnold
Post-Doc

Phone: +49 89 3187-3676
Fax: +49 89 3187-3585
E-mail
Building/Room: 56/158

 

Open Researcher and Contributor ID

ORCID: http://orcid.org/0000-0002-4666-0923

 

Research Interests

  • Functional annotation of single nucleotide variants (SNVs) and polymorphisms (SNPs) – www.SNiPA.org

  • Multi-omics analysis of biochemical trajectories in Alzheimer's disease – http://sites.duke.edu/adnimetab/

  • Analysis of genetically influenced protein levels – http://proteomics.gwas.eu/

  • Analysis of genetically influenced metabotypes – http://www.gwas.eu/si

  • Integrative analysis of regulatory genetic variation

  • Genome-wide association study (GWAS) and meta-analysis

OT Research Interests

  • Origin, symptoms, comorbidities, types of therapy, treatment and management of chronic pain

 

Teaching

  • Practical training, Lecture series 'Genome-oriented Bioinformatics' (WS2014/15)

  • Lecture 'Systems Biology of Diseases and Drug Treatment' (WS2013/14)

  • Practical training, Lecture series 'Genome-oriented Bioinformatics' (WS2012/13)

  • Practical training, Lecture series 'Genome-oriented Bioinformatics' (WS2011/12)

Supervised Theses

  • Kinga Balász: "A comparative, cross-platform chromosome X-wide association study of genetic influences on blood and urinary metabolites" (Master Thesis, 2015)
  • Niklas de Andrade Krätzig: "Mapping of established biomarkers in routine clinical use to complex trait associated genetic loci" (Bachelor Thesis, 2015)
  • Nick Lehner: "Evaluation of the applicability of current promoter and enhancer annotations for the prediction of regulatory genetic variant effects using intrinsic and extrinsic classification testing" (Bachelor Thesis, 2015)
  • Quirin Heiß: "Integration of human metabolome-wide association studies to estimate specificities of metabolite markers for individual phenotypes" (Bachelor Thesis, 2015)
  • David Fuggersberger: "Integrative Analysis of Metabolite Profiles in Human Traits Using Selected Published Metabolome-Wide Association Studies" (Bachelor Thesis, 2013)
  • Christof F. Schramm: "A KNIME-based Tool for Automatizing Genome-Wide Association Analysis Workflows" (Bachelor Thesis, 2013)
  • Kinga Balázs: "A Probabilistic Approach to Classify Phenotypes Using Locus-based Genetic Variability Maps" (Bachelor Thesis, 2012)

 

Curriculum Vitae

since Aug./2016Post-Doctoral Research Associate, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany
April/2014 - Aug./2016Research Associate, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany
July/2011 - March/2014Research Assistant (PhD student), Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany
July/2009 - June/2011Student assistant at the BIS group, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany
Oct./2006 - March/2011German Diploma (eq. M.Sc.) in Bioinformatics, Technische Universität München and Ludwig-Maximilians-Universität München, Germany

 

Conference Contributions

  1. Arnold M, Raffler J, Pfeufer A, Suhre K, Kastenmüller G (2015)
    SNiPA regulatory: A catalog of experimentally identified promoter and enhancer regions
    26. Jahrestagung der Deutschen Gesellschaft für Humangenetik, Graz, Austria
    medizinische genetik: doi:10.1007/s11825-015-0041-7 (Abstract)

  2. Arnold M, Raffler J, Pfeufer A, Suhre K, Kastenmüller G (2014)
    An extensive, interactive variant-centered annotation browser
    European Human Genetics Conference 2014, Milan, Italy

  3. Baurecht H, Rodriguez E, Arnold M, Hartsperger ML, Wachinger B, Franke A, Kabesch M, Winkelmann J, Pfeufer A, Romanos M, Illig T, Mewes HW, Stümpflen V, Weidinger S (2013)
    Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases
    European Mathematical Genetics Meeting 2013, Leiden, The Netherlands

  4. Vennemann M, Arnold M, Cohen M, Mitchell EA, Donner M, Mage DT, Plötz T, Meitinger T, Peters A, Mewes HW, Bajanowski T, Pfeufer A (2013)
    Genome-wide association study of SIDS predisposing genetic variation identifies association to 15q11 within the PWS/AS region
    24. Jahrestagung der Deutschen Gesellschaft für Humangenetik, Dresden, Germany
    medizinische genetik: doi:10.1007/s11825-013-0376-x (Abstract)

 

Peer-Reviewed Publications

  1. Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MY, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium (2017)
    Metabolic network failures in Alzheimer's disease -- A biochemical road map
    Alzheimer’s & Dementia: doi:10.1016/j.jalz.2017.01.020

  2. Suhre K, Arnold M, Bhagwat A, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MM, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J (2017)
    Connecting genetic risk to disease endpoints through the human blood plasma proteome
    Nature Communications: doi:10.1038/ncomms14357

  3. Fard D, Läer K, Rothämel T, Schürmann P, Arnold M, Cohen M, Vennemann M, Pfeiffer H, Bajanowski T, Pfeufer A, Dörk T, Klintschar M (2016)
    Candidate gene variants of the immune system and sudden infant death syndrome
    International Journal of Legal Medicine: doi:10.1007/s00414-016-1347-y

  4. Raffler J, Friedrich N, Arnold M, Kacprowski T, Rueedi R, Altmaier E, Bergmann S, Budde K, Gieger C, Homuth G, Pietzner M, Römisch-Margl W, Strauch K, Völzke H, Waldenberger M, Wallaschofski H, Nauck M, Völker U, Kastenmüller G, Suhre K (2015)
    Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality
    PLoS Genetics: doi:10.1371/journal.pgen.1005487

  5. Arnold M*, Raffler J*, Pfeufer A, Suhre K, Kastenmüller G (2015)
    SNiPA: an interactive, genetic variant-centered annotation browser
    Bioinformatics: doi:10.1093/bioinformatics/btu779

  6. Shin SY*, Fauman EB*, Petersen AK*, Krumsiek J*, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, The MuTHER Consortium, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K*, Brosnan MJ*, Gieger C*, Kastenmüller G*,†, Spector TD*,†, Soranzo N*,† (2014)
    An atlas of genetic influences on human blood metabolites.
    Nature Genetics: doi:10.1038/ng.2982

  7. Wjst M, Sargurupremraj M, Arnold M (2013)
    Genome-wide association studies in asthma: what they really told us about pathogenesis.
    Current Opinion in Allergy & Clinical Immunology: doi:10.1097/ACI.0b013e32835c1674

  8. Arnold M*,†, Hartsperger ML*, Baurecht H*, Rodríguez E, Wachinger B, Franke A, Kabesch M, Winkelmann J, Pfeufer A, Romanos M, Illig T, Mewes HW, Stümpflen V, Weidinger S (2012)
    Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases.
    BMC Genomics: doi:10.1186/1471-2164-13-490

  9. Arnold M*, Ellwanger DC*, Hartsperger ML, Pfeufer A, Stümpflen V (2012)
    Cis-Acting Polymorphisms Affect Complex Traits through Modifications of MicroRNA Regulation Pathways.
    PLoS ONE: doi:10.1371/journal.pone.0036694

  10. Arnold B, Häuser W, Arnold M, Bernateck M, Bernardy K, Brückle W, Friedel E, Hesselschwerdt HJ, Jäckel W, Köllner V, Kühn E, Petzke F, Settan M, Weigl M, Winter E, Offenbächer M (2012)
    Multicomponent therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline.
    Der Schmerz: doi:10.1007/s00482-012-1173-1

* equal contributors
 co-corresponding authors