The largest genome-wide association study on proteomics to date was published
Connecting genetic risk to disease endpoints through the human blood plasma proteome
Karsten Suhre, Matthias Arnold, Aditya Bhagwat, Richard J Cotton, Rudolf Engelke, Annika Laser, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook-Kanamori, Eman K. Al-Dous, Yasmin A. Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert, Annette Peters, Gabi Kastenmuller, Christian Gieger, Johannes Grauman
was published in Nature Communications.
The international team of scientists identified many independent, SNP-protein associations in a German cohort and replicated this GWAS in an Arab/Asian cohort as well. These associations represent novel, inter-chromosomal links to disease endpoints (like Alzheimer's disease, cancer, cardiovascular disease etc.). All the information was integrated into a genome-proteome network which can be interactively interrogated.