Curation of Human Disease Networks

Dr. Goar Frishman

Phone: +49 89 3187-3618
Building/Room: 56/148

Member of Research Group: Curation of Human Disease Networks

Curriculum Vitae

  • M.S. University of Yerewan, Chair of Genetics and Cytology, 1983, Armenia
  • Ph.D. Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 1986, Russia
  • 1987-1990 Technological Institute for Amino Acids, Yerevan, Armenia
  • 1990-1991 Institute for Cytology, Russian Academy of Sciences, St.Petersburg, Russia
  • 1992-1995 European Molecular Biology Laboratory, Heidelberg, Germany
  • 1996-1998 Max-Plank Institute for Biochemistry, Munich, Germany
  • 1999-present Helmholtz Zentrum, IBIS, Munich, Germany


Allebrandt KV, Teder-Laving M, Cusumano P, Frishman G, Levandovski R, Ruepp A, Hidalgo MPL, Costa R, Metspalu A, Roenneberg T, De Pittà C. Identifying pathways modulating sleep duration: from genomics to transcriptomics. Sci Rep. (Jul 2017)

Kostareva, A., Kiselev, A., Gudkova, A., Frishman, G., Ruepp, A., Frishman, D., Smolina, N., Tarnovskaya, S., Nilsson, D., Zlotina, A., Khodyuchenko, T., Vershinina, T., Pervunina, T., Klyushina, A., Kozlenok, A., Sjoberg, G., Golovljova, I., Sejersen, T., Shlyakhto, E. Genetic spectrum of idiopathic restrictive cardiomyopathy uncovered by next-generation sequencing. PLoS ONE 11:e0163362 (2016)  PMID: 27662471

Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034. PMID: 26050039

Mehta D, Newport DJ, Frishman G, Kraus L, Rex-Haffner M, Ritchie JC, Lori A, Knight BT, Stagnaro E, Ruepp A, Stowe ZN, Binder EB. Early predictive biomarkers for postpartum depression point to a role for estrogen receptor signaling. Psychol Med. 2014 Aug;44(11):2309-22. doi: 10.1017/S0033291713003231. PMID: 24495551

Blohm P, Frishman G, Smialowski P, Goebels F, Wachinger B, Ruepp A, Frishman D. Negatome 2.0: a database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis. Nucleic Acids Res. 2014 Jan;42(Database issue):D396-400. doi: 10.1093/nar/gkt1079. PMID: 24214996

Lechner M, Höhn V, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Kastenmüller G, Waegele B, Ruepp A.
CIDeR: multifactorial interaction networks in human diseases. Genome Biol. 2012 Jul 18;13(7):R62

Ruepp A, Kowarsch A, Schmidl D, Bruggenthin F, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Theis FJ. PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes. Genome Biol. 2010 Jan 20;11(1):R6

Smialowski P, Pagel P, Wong P, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Rattei T, Frishman D, Ruepp A. The Negatome database: a reference set of non-interacting protein pairs. Nucleic Acids Res. 2010 Jan;38(Database issue):D540-4

Ruepp A, Waegele B, Lechner M, Brauner B, Dunger-Kaltenbach I, Fobo G, Frishman G, Montrone C, Mewes HW. CORUM: the comprehensive resource of mammalian protein complexes--2009. Nucleic Acids Res. 2010 Jan;38(Database issue):D497-501

Ruepp A, Brauner B, Dunger-Kaltenbach I, Frishman G, Montrone C, Stransky M, Waegele B, Schmidt T, Doudieu ON, Stümpflen V, Mewes HW. CORUM: the comprehensive resource of mammalian protein complexes. Nucleic Acids Res. 2008 Jan;36(Database issue):D646-50. doi: 10.1093/nar/gkp914. PMID: 19884131

Artamonova II, Frishman G, Frishman D. Applying negative rule mining to improve genome annotation. BMC Bioinformatics. 2007 Jul 21;8:261.

Andreas Ruepp, Octave Noubibou Doudieu, Jos van den Oever, Barbara Brauner, Irmtraud Dunger-Kaltenbach, Gisela Fobo, Goar Frishman, Corinna Montrone, Christine Skornia, Steffi Wanka, Thomas Rattei, Philipp Pagel, M. Louise Riley, Dmitrij Frishman, Dimitrij Surmeli, Igor V. Tetko, Matthias Oesterheld, Volker Stuempflen, Hans-Werner Mewes . The Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context. Nucleic Acids Research 34(Database-Issue): 568-571 (2006)

Igor V. Tetko, Barbara Brauner, Irmtraud Dunger-Kaltenbach, Goar Frishman, Corinna Montrone, Gisela Fobo, Andreas Ruepp, Alexey V. Antonov, Dimitrij Surmeli, Hans-Werner Mewes. MIPS bacterial genomes functional annotation benchmark dataset. Bioinformatics 21(10): 2520-2521 (2005)

Philipp Pagel , Stefan Kovac , Matthias Oesterheld , Barbara Brauner, Irmtraud Dunger-Kaltenbach, Goar Frishman, Corinna Montrone, Pekka Mark, Volker Stuempflen, Hans-Werner Mewes, Andreas Ruepp and Dmitrij Frishman. The MIPS mammalian protein-protein interaction database. Bioinformatics 21(6): 832-834 (2005)

Artamonova II, Frishman G, Gelfand MS, Frishman D. Mining sequence annotation databanks for association patterns. Bioinformatics. 2005 Nov 1;21 Suppl 3:iii49-57.

Vonskii MS, Astvatsaturiants GV, Borkhsenius SN. Expression of heat shock proteins in mycoplasma. Dokl Akad Nauk. 1993 Jul;331(1):112-5.

Astvatsaturiants GV, Lisenkov AF, Smirnov IuV, Shakulov RS. Isolation of mutants with impaired retroinhibition of histidine biosynthesis Genetika. 1988 Nov;24(11):1928-34.

Lisenkov AF, Astvatsaturiants GV, Smirnov IuV, Ezhel' SA. Cloning and expression of the histidine operon of Salmonella typhimurium in cells of Escherichia coli Mol Gen Mikrobiol Virusol. 1988 Jun;(6):37-43.

Perel'man BV, Shakulov RS, Smirnov IuV, Lisenkov AF, Astvatsaturiants GV. Metabolic regulation of the histidine operon in Escherichia coli and Salmonella typhimurium Mol Gen Mikrobiol Virusol. 1988 Jan;(1):36-40.

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