Metabolomics
Dr. Johannes Raffler
Team Leader Data Visualization and Integration Tools
Phone: +49 89 3187-49588
E-mail
Building/Room: 56/158
Member of Research Group: Metabolomics
Research Interests
- Genome-wide association studies with metabolomics and proteomics in blood, urine, and saliva
- Longitudinal studies and trial studies
- Development of web-based tools for visualization and analysis of -omics data
Curriculum Vitae
- 10/2003 - 05/2009: Studies of Bioinformatics at the Ludwig-Maximilians-Universität München (LMU) and the Technische Universität München (TUM)
- 08/2008 - 05/2009: Diploma thesis at the Institute of Bioinformatics and Systems Biology (IBIS) at the Helmholtz Zentrum München (HMGU).
Supervisor: Prof. Karsten Suhre.
Thesis: Data mining on high-resolution metabolomic data - 10/2009-4/2015: PhD student
Supervisor: Prof. Karsten Suhre.
Thesis: Genome-wide association studies with metabolic traits from NMR spectroscopy. - 10/2009 - 9/2012: DFG scholar in the international research training group "Regulation and Evolution of Cellular Systems".
- 10/2012 - 4/2018: Research fellow in the Metabolomics group (IBIS/HMGU)
- 5/2015 - 7/2018: Postdoctoral fellow in the Metabolomics group (IBIS/HMGU)
- since 8/2018: Team leader "Data Visualization and Integration Tools"
Publications
- Do KT, Wahl S, Raffler J, Molnos S, Laimighofer M, Adamski J, Suhre K, Strauch K, Peters A, Gieger C, Langenberg C, Stewart ID, Theis FJ, Grallert H, Kastenmüller G, Krumsiek J. Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies. Metabolomics (2018)
- Arnold M, Raffler J, Suhre K, Kastenmüller G. Datenbasierte Funktionsvorhersage krankheitsrelevanter genetischer Varianten. BioSpektrum (2018)
- Hamad S, Adornetto G, Naveja J, Ravindranath AC, Raffler J, Campillos M. HitPickV2: a Web Server to predict targets of chemical compounds. Bioinformatics (2018)
- Köttgen A, Raffler J, Sekula P, Kastenmüller G. Genome-Wide Association Studies of Metabolite Concentrations (mGWAS): Relevance for Nephrology. Semin Nephrol. (2018)
- Rueedi R, Mallol R, Raffler J, Lamparter D, Friedrich N, Vollenweider P, Waeber G, Kastenmüller G, Kutalik Z, Bergmann S. Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy. PLoS Comput Biol. (2017)
- Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader D. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. (2017)
- Suhre K, Arnold M*, Bhagwat AM*, Cotton RJ*, Engelke R*, Raffler J*, Sarwath H*, Thareja G*, Wahl A*, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J. Connecting genetic risk to disease end points through the human blood plasma proteome. Nature Communications (2017)
- Suhre K., Raffler J., Kastenmüller G. Biochemical Insights from Population Studies with Genetics and Metabolomics. Arch Biochem Biophys (2016)
- Raffler J., Friedrich N., Arnold M., Kacprowski T., Rueedi R., Altmaier E., Bergmann S., Budde K., Gieger C., Homuth G., Pietzner M., Römisch-Margl W., Strauch K., Völzke H., Waldenberger M., Wallaschofski H., Nauck M., Völker U., Kastenmüller G., Suhre K. Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality. PLoS Genetics (2015)
- Kastenmüller G., Raffler J., Gieger C., Suhre K. Genetics of human metabolism: an update. Human Molecular Genetics (2015)
- Arnold M.*, Raffler J.*, Pfeufer A., Suhre K., Kastenmüller G. SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics (2014). *equally contributing authors
- Raffler J., Römisch-Margl W., Petersen AK., Pagel P., Blöchl F., Hengstenberg C., Illig T., Meisinger C., Stark K., Wichmann HE., Adamski J., Gieger C., Kastenmüller G., Suhre K. Identification and MS assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med. 2013 Feb 15;5(2):13.
- Krug S., Kastenmüller G., Stückler F., Rist M.J., Skurk T., Sailer M., Raffler J., Römisch-Margl W., Adamski J., Prehn C., Frank T., Engel K.H., Hofmann T., Luy B., Zimmermann R., Moritz F., Schmitt-Kopplin P., Krumsiek J., Kremer W., Huber F., Oeh U., Theis F.J., Szymczak W., Hauner H., Suhre K., Daniel H. The dynamic range of the human metabolome revealed by challenges. FASEB J. 2012 Jun;26(6):2607-19.
- Petersen A.K., Stark K., Musameh M.D., Nelson C.P., Römisch-Margl W., Kremer W., Raffler J., Krug S., Skurk T., Rist M.J., Daniel H., Hauner H., Adamski J., Tomaszewski M., Döring A., Peters A., Wichmann H.E., Kaess B.M., Kalbitzer H.R., Huber F., Pfahlert V., Samani N.J., Kronenberg F., Dieplinger H., Illig T., Hengstenberg C., Suhre K., Gieger C., Kastenmüller G. Genetic associations with lipoprotein subfractions provide information on their biological nature. Hum Mol Genet. 2012 Mar 15;21(6):1433-43.
- Suhre K., Shin SY., Petersen AK., Mohney RP., Meredith D., Wägele B., Altmaier E; CARDIoGRAM., Deloukas P., Erdmann J., Grundberg E., Hammond CJ., de Angelis MH., Kastenmüller G., Köttgen A., Kronenberg F., Mangino M., Meisinger C., Meitinger T., Mewes HW., Milburn MV., Prehn C., Raffler J., Ried JS., Römisch-Margl W., Samani NJ., Small KS., Wichmann HE., Zhai G., Illig T., Spector TD., Adamski J., Soranzo N., Gieger C., Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477(7362):54-60, 2011.
- Suhre K., Wallaschofski H., Raffler J., Friedrich N., Haring R., Michael K., Wasner C., Krebs A., Kronenberg F., Chang D., Meisinger C., Wichmann H.-E., Hoffmann W., Völzke H., Völker U., Teumer A., Biffar R., Kocher T., Felix S.B., Illig T., Kroemer H.K., Gieger C., Römisch-Margl W., Nauck M., A genome-wide association study of metabolic traits in human urine Nature Genetics, 43:565-569, 2011.
