Optoacoustic Mesoscopy

Profile

Different layers of human skin obtained with RSOM.
Different layers of human skin obtained with RSOM.
a) Maximum intensity projection (MIP) in the coronal direction showing the Stratum corneum of the epidermis, b) MIP in the coronal direction showing vascular fingerprint of the dermal papillae, c) MIP in the coronal direction showing the subpapillary plexus, and d) MIP in the coronal direction showing the deep vessels of the papillary dermis. e) Cross section through human skin. (b-d) MIPs along the depth direction within the regions marked in (e).
All scale bars are 500 µm.

Our group conceives, designs and develops multispectral optoacoustic technology that allows performing non-invasive anatomical, functional and molecular optical imaging of the skin in the clinics. Our systems are designed to achieve a resolution to depth relation that is not accessible to the traditional optical imaging techniques.  As a result, high resolution capabilities across the whole skin depth are maintained. Within this framework we use our tools to image and quantify biologically and medically relevant features that were not possible to be monitored before.  Furthermore leveraging in our technology and collaborating with leading dermatologists we study several major skin disorders in order to catalyze biomedical discovery and to improve current dermatology praxis.

Group leader

Image Name Job Title E-mail Telephone Building/Room
Dr. Aguirre,
Juan
Group Leader E-mail +49 (0) 89 4140 9156 Einsteinstr. 25, TranslaTUM (bldg. 522), room 22.3.32

Relevant Publications

B. Hindelang, B.; Aguirre, J.; Schwarz, M.; Berezhnoi, A.; Eyerich, K.; Ntziachristos, V.; Biedermann, T.; Darsow, U. Non‐invasive imaging in dermatology and the unique potential of Raster‐Scan Optoacoustic Mesoscopy (RSOM) Journal of the European Academy of Dermatology and Venereology 13 November 2018 https://doi.org/10.1111/jdv.15342

Aguirre, J.; Hindelang, B.; Berezhnoi, A.; Darsow, U.; Lauffer, F.; Eyerich, K.; Biedermann, B.; Ntziachristos, V. Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy Photoacoustics Volume 10, June 2018 https://doi.org/10.1016/j.pacs.2018.02.002

Berezhnoi, A.; Schwarz, M.; Buehler A.; Ovsepian S. V.; Aguirre, J.; Ntziachristos V. Assessing hyperthermia‐induced vasodilation in human skin in vivo using optoacoustic mesoscopy Journal of Biophotonics Volume 11, Issue 11 Nov. 2018 https://doi.org/10.1002/jbio.201700359

Schwarz, M.; Garzorz-Stark,N.; Eyerich,K.; Aguirre, J.; Ntziachristos, V. Motion correction in optoacoustic mesoscopy Scientific Reports Volume 7, Article number: 10386 (2017) https://doi.org/10.1038/s41598-017-11277-y

Aguirre, J.; Schwarz, M.; Garzorz, N.; Omar, M.; Buehler, A.; Eyerich, K.; Ntziachristos, V. Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy. Nature Biomedical Engineering 1, 0068 (2017) doi:10.1038/s41551-017-0068

Schwarz, M. ; Omar, M. ; Bühler, A. ; Aguirre, J. ; Ntziachristos, V. Implications of ultrasound frequency in optoacoustic mesoscopy of the skin. IEEE Trans. Med. Imaging 34, 672-677 (2015)

Aguirre, J. ; Schwarz, M. ; Soliman, D. ; Bühler, A. ; Omar, M. ; Ntziachristos, V. Broadband mesoscopic optoacoustic tomography reveals skin layers. Opt. Lett. 39, 6297-6300 (2014)

People

Image Name Job Title E-mail Telephone Building/Room
Dr. Aguirre,
Juan
Group Leader E-mail +49 (0) 89 4140 9156 Einsteinstr. 25, TranslaTUM (bldg. 522), room 22.3.32
Dr. He,
Hailong
Postdoctoral Fellow E-mail +49 (0) 89 3187 4452 Einsteinstr. 25, TranslaTUM (bldg. 522), room 22.3.42
Schönmann,
Christine
Visiting Scientist E-mail Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein Gebäude 610, EG
Berezhnoi,
Andrei
Ph.D. Student E-mail +49 (0) 89 3187 4452 Einsteinstr. 25, TranslaTUM (bldg. 522), room 22.3.33

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