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08.11.2019

“Paint it black”: New method allows in vivo imaging of macrophage dynamics

Labeled Macrophages in vivo (arrows) in Optoacoustic tomography

Labeled Macrophages in vivo (arrows) in Optoacoustic tomography (top). Identity of macrophages confirmed on immunofluorescence (middle) and brightfield (bottom) cross-sections. ©Helmholtz Zentrum München/ IBMI

Macrophages are an essential part of the innate immune system with crucial functions during host defense against pathogens, tissue homeostasis, and during various inflammatory processes in the body caused by infection, allergic reaction or disease. Hence, their visualization, especially on the comprehensive level of following their dynamics in whole animals is an essential contributor to the better understanding of numerous diseases, e.g. cancer. The group for CellEngineering at the Institute for Biological and Medical Imaging at the Helmholtz Zentrum München, in collaboration with the Chair for Biological Imaging at the Technical University of Munich, developed a new method to facilitate such in vivo imaging of macrophage dynamics. Read more...