ICB Seminar


Computer-aided Cancer Vaccine Design

Dr. Benjamin Schubert, ICB

Monday, October 15th, 2018, 11.30 am, Seminar Room 121, Building 58a
Invited by Fabian Theis

Abstract: Therapeutic cancer vaccines promise to be a game-changing therapeutic approach in the fight against cancer. The vaccines are designed to target tumor-specific alterations that will be recognized as foreign by the individual’s immune system. The design process heavily relies on bioinformatics approaches and requires multi-omics integration. It involves two fundamental steps that are performed for each patient individually: (1) Vaccine candidates are identified given paired genetic information of the patient’s tumor and normal tissue. (2) A selection of vaccine candidate is made with the aim of inducing a strong and long-lasting immune response. In this seminar, I will introduce a computational workflow that systematically identifies, selects, and assembles the optimal set of tumor-specific antigens for vaccination by integrating paired exome and transcriptome data of healthy and tumor samples of a patient. The procedure is fully automated but can also be used interactively to aid the clinician in the design process, thus drastically accelerating the development time of the individualized immunotherapy.



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