Staff

Dr. Florian Büttner
Guest Scientist

E-mail

Research

Publications

  • Buettner F*, Natarajan KN*, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC & Stegle O, 2015. Accounting for cell-to-cell heterogeneity in single-cell RNA-Seq data reveals novel structure between cells, Nature Biotechnology, in the press.  *equal contribution
  • Sass S, Buettner F, Mueller NS & Theis FJ 2014. RAMONA: a web application for multilevel ontology analysis, Bioinformatics, btu610.
  • Schmidt AM, Fagerer SR, Jefimovs K, Buettner F, Marro C, Siringil E, Boehlen K, Pabst M & Ibanez AJ 2014. Molecular phenotypic profiling of a Saccharomyces cerevisiae strain at the single-cell level. Analyst139(22), 5710-5718.
  • Winkler C, Krumsiek J, Buettner F, Angermüller C, Giannopoulou EZ, Theis FJ, Ziegler AG, Bonifacio E 2014. Feature Ranking of Type 1 Diabetes Susceptibility Genes Improves Prediction of Type 1 Diabetes, Diabetologia57(12), 2521-2529.
  • Buettner F, Moignard V, Göttgens B & Theis FJ 2014. Probabilistic PCA of censored data: accounting for uncertainties in the visualisation of high-throughput single-cell qPCR data, Bioinformatics, btu134
  • Ebert MA, Gulliford SL, Buettner F, Foo K, Haworth A, Kennedy A, Joseph DJ & Denham JW 2014. Two non-parametric methods for derivation of constraints from radiotherapy dose-histogram data, Phys Med Biol 59(13), N101-N111
  • Sass S*, Buettner F*, Müller NS, Theis FJ. A modular framework for gene set analysis integrating multilevel omics data. Nucleic Acids Res. 2013 Aug 23 *equal contribution
  • Moignard V, Macaulay IC, Swiers G, Buettner F, Schütte J, Calero-Nieto FJ, Kinston S, Joshi A, Hannah R, Theis FJ, Jacobsen SE, Bruijn MFd, Göttgens B 2013 Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Nature Cell Biology, 15(4):363-72
  • Buettner F & Theis F J 2012 A novel approach for resolving differences in single-cell gene expression patterns from zygote to blastocyst. Bioinformatics 28(18):i626-i632
  • Buettner F, Gulliford S L, Webb S, Sydes M R, Dearnaley D P & Partridge M 2012 The dose-response of the anal sphincter region--an analysis of data from the MRC RT01 trial. Radiother Oncol 103(3),347-52
  • Buettner F, Miah AM , Gulliford S L, Hall E, Harrington KJ , Webb S, Partridge M & Nutting C M 2012 Novel approaches to improve the therapeutic index of head and neck radiotherapy: an analysis of data from the PARSPORT randomised phase III trial. Radiother Oncol 103(1),82-7
  • Buettner F, Gulliford S L, Webb S & Partridge M 2011 Modeling late rectal toxicities based on a parameterized representation of the 3D dose distribution. Phys Med Biol56(7)  2103-19
  • Buettner F, Gulliford S L, Webb S & Partridge M 2010 Using Bayesian logistic regression to evaluate a new type of dosimetric constraint for prostate radiotherapy treatment planning Med Phys 37(4), 1768-1777.
  • Buettner F, Gulliford S L, Webb S, Sydes M R, Dearnaley D P & Partridge M 2009b Assessing cor- relations between the spatial distribution of the dose to the rectal wall and late rectal toxicity after prostate radiotherapy: an analysis of data from the MRC RT01 trial (ISRCTN 47772397). Phys Med Biol 54(21), 6535-6548.
  • Buettner F, Gulliford S L, Webb S & Partridge M 2009a Using dose-surface maps to predict radiation- induced rectal bleeding: a neural network approach. Phys Med Biol 54(17), 5139-5153.
  • Seco J, Sharp G C, Wu Z, Gierga D, Buettner F & Paganetti H 2008 Dosimetric impact of motion in free-breathing and gated lung radiotherapy: A 4D Monte Carlo study of intrafraction and interfraction effects Med Phys 35(1), 356-366.
  • Volpe G, Singh GP, Buettner F, Morales A, Petrov D, 2006 Optical Trapping Dynamics for Cell Identification in Proc. SPIE 6326
  • Buettner F, Gulliford S L, Partridge M, Sydes M R, Dearnaley D P & Webb S 2009 Assessing correla- tions between the spatial distribution of dose to the rectal wall and late rectal toxicity after prostate radiotherapy in Proc. World Congress of Medical Physics and Biomedical Engineering, p. 908-911.
  • Buettner F, Gulliford SL, Webb S & Partridge M 2009 Using Bayesian logistic regression with high- order interactions to model radiation-induced toxicities following radiotherapy in Proc. 8th Int. Conf. on Machine Learning and Applications, p. 451-456.
  • Buettner F, Gulliford SL, Webb S & Partridge M 2010 Using a parameterized representation of the 3D dose distribution to predict radiation-induced toxicities in Proc. XVIth Conf. on the use of Computers in Radiotherapy.
  • Buettner F, Miah A B, Gulliford S L, Harrington J K, Webb S, Nutting C M & Partridge M 2010 Using a Bayesian Feature Selection Algorithm to Identify Dose-response Models Based on the Shape of the 3D Dose-distribution: An example from a head and neck trial in Proc. 9th Int. Conf. on Machine Learning and Applications, p. 740-45.

Curriculum Vitae

since 05/2012Team Leader at the Institute for Computational Biology, Helmholtz Zentrum Munich, Germany

11/2011-05/2012

Research Fellow (Postdoc) at the Computational Modeling in Biology group, Institute for Bioinformatics and Systems BiologyHelmholtz Zentrum Munich, Germany
10/2007-
09/2011

Research assistent (PhD student), The Institute of Cancer Research, University of London, London, UK

10/2006-
04/2007

Visiting M.Sc. student, Massachusetts General Hospital and Harvard Medical School, Boston, USA.

05/2006-
04/2007

M.Sc. medical physics, Ruprecht-Karls-Universität Heidelberg, Germany

06/2005-
09/2005

Summer student, Institut de Ciències Fotòniques (ICFO), Barcelona, Spain.

10/2001-
10/2007
German Diplom (eq. M.Sc.) in physics, Ruprecht-Karls-Universität Heidelberg, Germany

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.