Source: HMGU

Dr. Maria Colomé-Tatché
Research Group Leader

Phone: +49 89 3187-49402
Building/Room: 58a / 004

Google Scholar Profile

ResearchGate Profile


Short CV

I did my Bachelor’s and Master’s in Physics at the Autonomus University of Barcelona (2005). I also obtained a Master’s degree in Theoretical Physics at the Ecole Normale Superieure in Paris (2005) and a PhD in Physics at the Laboratory of Theoretical Physics and Statistical Models (University of Paris Sud) (2008). After a short postdoctoral stay at the Theoretical Quantum Optics Group (Institute for Theoretical Physics, University of Hannover), I moved to the Groningen Bioinformatics Centre where I transitioned into the field of quantitative biology, being involved in some of the first large scale population epigenetic studies in model organisms.

Since 2013 I am a Rosalind Franklin Fellow at the Department of the Biology of Ageing (European Research Institute for the Biology of Ageing – ERIBA, University of Groningen and University Medical Centre Groningen), and since 2016 I am also a Helmholtz Young Investigator's Group Leader at the Institute of Computational Biology (Helmholtz Zentrum München). 


  • Analysis and interpretation of epigenetics data
    • Analysis of ChIP-seq data for large numbers of histone modifications and/or transcription factors (bulk sequencing) chromstaR
    • Analysis of low-input ChIP-seq data (few hundred cells) for several histone modifications
    • Analysis of single cell DNA methylation data (sc-BS-seq)
    • Integration of histone modification data, DNA methylation data and higher order phenotypes
  • Modeling of epigenetic processes
    • Inheritance of epigenetic states (meiotic/mitotic)
    • Stochastic gains and losses of epigenetic marks (epimutation rates)
    • Population epigenetics and epigenomics

Selected publications

Hanna CW, Taudt A, Huang J, Gahurova L, Kranz A, Andrews S, Dean W, Stewart AF, Colomé-Tatché M, , Kelsey G. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. Nat Struct Mol Biol., 25(1):73-82 (2018).

Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M*, Foijer F* (*corresponding authors). Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies. Genome Biology, 17:115. (2016).

Taudt A, Colomé-Tatché M and Johannes F. Genetic sources of population epigenomic variation. Nature Reviews Genetics, 17, 319 (2016).

vd Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC, Schmitz RJ*, Colomé-Tatché M* and Johannes F* (*corresponding authors). Rate, spectrum and evolutionary dynamics of spontaneous epimutations. Proc. Natl. Acad. Sci. USA, 112:6676-81 (2015).

Heinig M, Colome-Tatche M, Rintisch C, Schäfer S, Pravenec M, Hubner N, Vingron M, Johannes F. histoneHMM: Differential analysis of histone modifications with broad genomic footprints. BMC Bioinformatics, 16:60 (2015).

Cortijo S*, Wardenaar R*, Colomé-Tatché M*, Gilly A, Etcheverry M, Labadie K, Caillieux E, Hospital F, Aury J-M, Wincker P, Roudier F, Jansen RC, Colot V, Johannes F (*equal contributions). Mapping the epigenetic basis of complex traits. Science, 343:1145-48 (2014).

Colomé-Tatché M, Cortijo S, Wardenaar R, Lahouze B, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, V Colot and Johannes F. Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc. Natl. Acad. Sci. USA, doi: 10.1073/pnas.1212955109 (2012).

Roux F*, Colomé-Tatché M*, Edelist C, Wardenaar R, Guerche P, Hospital F, Colot V, Jansen RC, Johannes F (*equal contributions). Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature. Genetics, 188, 1015 (2011).

Johannes F and Colomé-Tatché M. Quantitative Epigenetics Through Epigenomic Perturbation of Isogenic Lines. Genetics, 188, 215 (2011).

We use cookies to improve your experience on our Website. We need cookies to continually improve our services, enable certain features, and when we embed third-party services or content, such as the Vimeo video player or Twitter feeds. In such cases, information may also be transferred to third parties. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.