Staff

Dr. Maria Colomé-Tatché
Junior Group Leader Computational Epigenomics

Phone: +49 89 3187-49402
E-mail
Building/Room: 58a / 004

 

Short CV

I did my Bachelor’s and Master’s in Physics at the Autonomus University of Barcelona (2005). I also obtained a Master’s degree in Theoretical Physics at the Ecole Normale Superieure in Paris (2005) and a PhD in Physics at the Laboratory of Theoretical Physics and Statistical Models (University of Paris Sud) (2008). After a short postdoctoral stay at the Theoretical Quantum Optics Group (Institute for Theoretical Physics, University of Hannover), I moved to the Groningen Bioinformatics Centre where I transitioned into the field of quantitative biology, being involved in some of the first large scale population epigenetic studies in model organisms.

Since 2013 I am a Rosalind Franklin Fellow at the Department of the Biology of Ageing (European Research Institute for the Biology of Ageing – ERIBA, University of Groningen and University Medical Centre Groningen), and since 2016 I am also a Helmholtz Young Investigator's Group Leader at the Institute of Computational Biology (Helmholtz Zentrum München). 

Research

  • Analysis and interpretation of epigenetics data
    • Analysis of ChIP-seq data for large numbers of histone modifications and/or transcription factors (bulk sequencing) chromstaR
    • Analysis of low-input ChIP-seq data (few hundred cells) for several histone modifications
    • Analysis of single cell DNA methylation data (sc-BS-seq)
    • Integration of histone modification data, DNA methylation data and higher order phenotypes
  • Modeling of epigenetic processes
    • Inheritance of epigenetic states (meiotic/mitotic)
    • Stochastic gains and losses of epigenetic marks (epimutation rates)
    • Population epigenetics and epigenomics

Selected publications

Hanna CW, Taudt A, Huang J, Gahurova L, Kranz A, Andrews S, Dean W, Stewart AF, Colomé-Tatché M, , Kelsey G. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. Nat Struct Mol Biol., 25(1):73-82 (2018).

Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M*, Foijer F* (*corresponding authors). Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies. Genome Biology, 17:115. (2016).

Taudt A, Colomé-Tatché M and Johannes F. Genetic sources of population epigenomic variation. Nature Reviews Genetics, 17, 319 (2016).

vd Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC, Schmitz RJ*, Colomé-Tatché M* and Johannes F* (*corresponding authors). Rate, spectrum and evolutionary dynamics of spontaneous epimutations. Proc. Natl. Acad. Sci. USA, 112:6676-81 (2015).

Heinig M, Colome-Tatche M, Rintisch C, Schäfer S, Pravenec M, Hubner N, Vingron M, Johannes F. histoneHMM: Differential analysis of histone modifications with broad genomic footprints. BMC Bioinformatics, 16:60 (2015).

Cortijo S*, Wardenaar R*, Colomé-Tatché M*, Gilly A, Etcheverry M, Labadie K, Caillieux E, Hospital F, Aury J-M, Wincker P, Roudier F, Jansen RC, Colot V, Johannes F (*equal contributions). Mapping the epigenetic basis of complex traits. Science, 343:1145-48 (2014).

Colomé-Tatché M, Cortijo S, Wardenaar R, Lahouze B, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, V Colot and Johannes F. Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc. Natl. Acad. Sci. USA, doi: 10.1073/pnas.1212955109 (2012).

Roux F*, Colomé-Tatché M*, Edelist C, Wardenaar R, Guerche P, Hospital F, Colot V, Jansen RC, Johannes F (*equal contributions). Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature. Genetics, 188, 1015 (2011).

Johannes F and Colomé-Tatché M. Quantitative Epigenetics Through Epigenomic Perturbation of Isogenic Lines. Genetics, 188, 215 (2011).

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