Adjunct Assistant Professor

Department of Psychiatry and Behavioral Sciences
Duke University
Profile: Psychiatry@Duke
E-mail

Open Researcher and Contributor ID

ORCID: http://orcid.org/0000-0002-4666-0923
(view for full list of publications)

Research Interests

• Functional annotation of single nucleotide variants (SNVs) and polymorphisms (SNPs) – www.SNiPA.org

• Multi-omics analysis of biochemical trajectories in Alzheimer's disease – http://sites.duke.edu/adnimetab/

• Analysis of genetically influenced protein levels – http://proteomics.gwas.eu/

• Analysis of genetically influenced metabotypes – http://www.gwas.eu/si

Recent Invited Talks

Selected Publications

1. Arnold M*, Nho K*, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G (2020)
   Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
   Nature Communications: doi:10.1038/s41467-020-14959-w
   
   
2. MahmoudianDehkordi S^*, Arnold M^*, Nho K^*, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, Bhattacharyya S, Toledo JB, Schafferer S, Klein S, Koal T, Risacher SL, Kling MA, Motsinger-Reif A, Rotroff DM, Jack J, Hankemeier T, Bennett DA, De Jager PL, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, van Duijn CM, Saykin AJ, Kastenmüller G, Kaddurah-Daouk R; for the Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. (2019)
   Altered bile acid profile associates with cognitive impairment in Alzheimer's disease – An emerging role for gut microbiome
   Alzheimer’s & Dementia: doi:10.1016/j.jalz.2018.07.217
   
   
3. Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MY, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium (2017)
   Metabolic network failures in Alzheimer's disease – A biochemical road map
   Alzheimer’s & Dementia: doi:10.1016/j.jalz.2017.01.020
   
   
4. Suhre K, Arnold M, Bhagwat A, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MM, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J (2017)
   Connecting genetic risk to disease endpoints through the human blood plasma proteome
   Nature Communications: doi:10.1038/ncomms14357
   
   
5. Arnold M^*, Raffler J^*, Pfeufer A, Suhre K, Kastenmüller G (2015)
   SNiPA: an interactive, genetic variant-centered annotation browser
   Bioinformatics: doi:10.1093/bioinformatics/btu779
   
   
6. Shin SY^*, Fauman EB^*, Petersen AK^*, Krumsiek J^*, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, The MuTHER Consortium, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K^*, Brosnan MJ^*, Gieger C^*, Kastenmüller G^*,†, Spector TD^*,†, Soranzo N^*,† (2014)
   An atlas of genetic influences on human blood metabolites.
   Nature Genetics: doi:10.1038/ng.2982

^* equal contributors