Multi-Scale Stochastic Modeling

The Priority Program Pluripotency and Cellular Reprogramming of the German Research Foundation DFG is in its 2nd funding period and aims at the identification and characterization of genetic and epigenetic networks that control pluripotency and mechanisms governing the reinstatement of pluripotency in a differentiated cell.
In our project, we propose to use stochastic multi-scale modeling techniques to further our understanding of stem cell maintenance and exit of pluripotency. Our key goals are (a) the integration of diverse information into a single model of pluripotency, (b) the prediction of novel molecular interactions and (c) quantitative predictions on systems perturbations e.g. for reprogramming.
Pluripotency and Cellular Reprogramming homepage