In Systems Biology of Metabolic Phenotypes (SysMbo) we aim to combine information from genetic variation with information gained by quantitative MS/MS analysis of metabolic profiles from serum and tissue samples. Our goal is to uncover genotype/environment/phenotype relations with an emphasis on lipid metabolism and to make relevant contributions to the understanding of disease mechanisms.
The contribution of CMB in this consortium is to develop quantitative metabolic models. For each study (population genetics, nutritional challenging, metabolic mouse models, mitochondriopathies and rare diseases) and each experimental stage, we will develop a quantitative, local pathway model that integrates the relevant experimental perturbation. This model will be used to predict future experimental variations.
SysMBo homepage