The analysis of complex biological regulatory systems is an interdisciplinary undertaking which requires the coordinated cooperation of biochemistry, genetics, bioinformatics, biophysics and medicine. By applying innovative methods, the bavarian research network investigates the regulation of the genome on cellular as well as molecular level.
The contribution of CMB in this network is to quantify regulatory mechanisms on the transcriptional level based on time-lapse microscopy of differentiating stem cells. The goal is to learn a predictor in order to accurately determine the time-point of cellular fate decision on the single-cell level, thus allowing experimentation at the decision event.
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* external authors, # joint first authors, ° joint corresponding authors