e:Med - SYS-Stomach

Gastric cancer was estimated to be the fourth most common cancer and second leading cause of death from cancer worldwide. Treatment options for gastric cancer patients include surgery, chemotherapy and radiation therapy. However, the overall survival rate remains unsatisfactory and new treatment options are urgently required. We will apply systematic molecular and, motility focused, cell phenotypic measurements. From these we derive probabilistic models of the basic signalling networks coupled to cellular phenotypes and agent based cellular behaviour models which give rise to emergent tumor characteristics. These models together with biostatistical methods will inform conclusions about the mechanisms leading to differences in the response of gastric cancer cell lines treated with novel drugs.
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* external authors, # joint first authors, ° joint corresponding authors

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