Selected Publication


A complete cell atlas and lineage tree of the immortal flatworm

The research team was able to create a detailed cell atlas of the flatworm Schmidtea mediterranea. © Salah Ayoub, BIMSB/MDC and Jordi Solana, BIMSB/MDC

Scientists from the Max Delbrück Center (MDC) for Molecular Medicine (MDC) together with researchers from ICB published a comprehensive lineage tree of a whole animal in 'Science'.

By combining single-cell RNA technology with nucleic acid sequencing and computer-based analysis methods, the research team from Berlin and Munich created a detailed cell atlas of a complex adult organism, the flatworm Schmidtea mediterranea, and reconstructed a comprehensive lineage tree of the identified cells.

For more information, see the press release by the Helmholtz Zentrum München, the press release by MDC, the original publication Plass, M. et al. (2018): Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science, DOI:10.1126/scienc.aaq1723, and the methods paper Wolf, A. et al. (2018): Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells. DOI:

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Only cookies permitted that are required for the basic functionality of our websites.
Permit cookies that help us to analyse the page views and user behavior on our websites. We only use this information for improving our services.
Permit embedded content and cookies from third party providers. This setting enables the full use of our web services (e.g. displaying videos).
Please find more information in our privacy statement.

There you may also change your settings later.