Selected Publication


Inference of differentiation decision timepoints

Molecular markers that report a particular cell fate choice are usually delayed - and the time of decision making is therefore unknown. Fortunately, dividing cells induce temporal correlations in their progeny, which allow for retrospective inference of the decision time point. 

Our computational method allows to infer decision time points from correlated marker signals in genealogies. We apply it to differentiating hematopoietic stem cells and find that the PU.1/GATA1 toggle switch paradigm cannot explain the initiation of early myeloid lineage choice.

For more information, see the original publication: Strasser, M. et al. (2018): Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm. Nat. Comm.



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