Selected Publication

23.07.2018

Inference of differentiation decision timepoints

Molecular markers that report a particular cell fate choice are usually delayed - and the time of decision making is therefore unknown. Fortunately, dividing cells induce temporal correlations in their progeny, which allow for retrospective inference of the decision time point. 

Our computational method allows to infer decision time points from correlated marker signals in genealogies. We apply it to differentiating hematopoietic stem cells and find that the PU.1/GATA1 toggle switch paradigm cannot explain the initiation of early myeloid lineage choice.

For more information, see the original publication: Strasser, M. et al. (2018): Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm. Nat. Comm.

 

 

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.